Syntheses of Some N-Substituted Thiocarbamylpiperidines and Thiocarbamylmorpholines

Syntheses of some N-substituted thiocarbamylpiperidines (I-VIII) and thiocarbamylμiorpholines (IX-XVIII) from piperidine or morpholine and the corresponding isothiocyanaites are described. The substances were tested for their tuberculostatic activity

Syntheses in the 4-Substituted Thiosemicarbazide Series

In connection with the investigations of tuberculostatic activity of arylthiosemicarbazides and arylthiosemicarbazones new 4-substituted thiosemicarbazides (I-XVIII) were synthesized. Condensation of these with aldehydes or ketones afforded the corresponding 4-substituted thiosemicarbazones (XIX-LVI). The attempted \u27acetylation of p-nitrobenzaldehyde-4-phenylthiosemicarbazone and o - chlorobenzaldehyde - 4 - phenylthiosemicarbazone gave besddes acetanilide N,N.-diacetyl-p-nitrobenzylidenhydrazine (LVII) ,and N,N-dia cetyl-chlorobenzylidenehydrazine (LIX) .The 4-substituted thiosemic arbazides and thiosemiearbazones were tested for their tuberculostatic activity

Synthesis of Isomeric 3-Aminopyridopyrimidin-4(3H)ones

It could be established that the reaction between hydrazine and enamines, formed from ethyl 2(or 3)-aminopyridine-3(or 2)carboxylates and diethyl ethoxymethylenemalonate or ethyl ethoxymethylenecyanoacetate, afforded 3-aminopyrido(2,3-d)pyrimidin- 4(3H)one or 3-aminopyrido(3,2-d)pyrimidin-4(3H)one, respectively. Similarly, these aminopyridinecarboxylates condense with N,N- dimethylformamide dimethylacetal and react further with hydrazine to give the same bicyclic compounds

Contribution to the Structm·e of 2,5-Dimercapto-1,3,4-thiadiazole and Related Compounds

The structure of 2,5 - dimercapto-1,3,4-thiadiazole and some derivatives was studied from the dependence of UV spectra on pH and H 0 and a monomercapto monodipolar structure is proposed. Evidence was presented tha t addition reactions of 2,5-dimercapto- 1 ,3,4-thiadiazoles on unsaturated systems proceed with the formation of S-akyla ted derivatives involving thus the mercapto group

Structure of Some s-Triazoloquinazolinones

Reaction between 3-amino-1,2,4-triazole and 2-carbethoxycyclohexanone can theoretically afford the tricyclic product of the types IV-VII. It was established that the product has structure V and similarly for other cyclization products structures are proposed

Contribution to the Structm·e of 2,5-Dimercapto-1,3,4-thiadiazole and Related Compounds

The structure of 2,5 - dimercapto-1,3,4-thiadiazole and some derivatives was studied from the dependence of UV spectra on pH and H 0 and a monomercapto monodipolar structure is proposed. Evidence was presented tha t addition reactions of 2,5-dimercapto- 1 ,3,4-thiadiazoles on unsaturated systems proceed with the formation of S-akyla ted derivatives involving thus the mercapto group

Some Derivatives of Perhydro-imidazo(l,5-a)pyridine and Perhydro-pyrrolo(l,2-c)imidazole

Some derivatives o:t perhydro-imidazo(l,5-a)pyridine and -pyrrolo(l,2-c)imidazole were synthesized and a new synthetic route was also developed. This synthesis and other chemical and spectroscopical evidence indicates the structure for these substances with the exo-cyclic sulphur