Developing optimal ventilation system for a pasta production workshop using mathematical model

The more real conditions differ from the rated ones,the greater error is observed when calculating the aerodynamics and air temperature for specific premises. The paper considers a technique for estimating the efficiency of ventilation systems at the stage of choosing design solutions using mathematical simulation exemplified by a pasta production workshop in Magnitogorsk. Two air change circuits with central and local air conditioners to remove heat have been estimated. Mathematical models were built with the boundary conditions preset,which allowed visually estimating the airflow temperature and velocity field distribution for the circuits studied. Based on the simulation results,conclusions have been drawn on the efficiency of the circuits proposed. © Published under licence by IOP Publishing Ltd

PROFESSIONAL STANDARDS AS TOOLS TO SUPPORT THE DEVELOPMENT OF THE MODEL GRADUATE OF THE BASIC PROFESSIONAL EDUCATIONAL PROGRAMS OF HIGHER EDUCATION «THE TECHNOLOGY OF IMAGE IN THE INDUSTRY OF FASHION AND BEAUTY»

В статье рассматривается основные подходы к разработке модели выпускника основной профессиональной образовательной программы высшего образования «Технологии имиджа в идустрии моды и красоты»The article deals with the main approaches to the development of the model of the graduate of the basic professional educational program of higher education "technologies of image in the fashion and beauty industr

Results of the Assessment of Possibilities and Prospects of Using Blockchain Technology in the Production Activities of Enterprises

The basics of Blockchain technology and its application in various fields of activity are considered. The object of the research is Blockchain technology and the possibilities of its application in industries. This involves a detailed study of its fundamental components – decentralized network, mathematical cryptography, distributed consensus, transaction ledger and smart contracts, as well as their application, in particular, for automating and securing transactions and processes using smart contracts. The main problem to be solved is the integration of secure, transparent and efficient mechanisms for recording and processing transactions, as well as automating processes at different stages of production. The use of Blockchain, or rather smart contracts, has significantly improved production processes by automating routine operations and ensuring the security of transactions. Smart contracts developed using the Ethereum platform and the Solidity language are able to optimize production processes, but they are not devoid of risks, such as code bugs and cybersecurity issues. It is emphasized that the integration of Blockchain into production processes requires a basic understanding of the technology, a clear implementation strategy, and initial investment in infrastructure and integration. Despite the initial difficulties, the benefits of using Blockchain in terms of transparency, efficiency, and reliability can be significant, as evidenced by several specific examples. The authors explore the potential of smart contracts at different stages of the production cycle, highlighting the benefits in automating processes and ensuring security. The results show that smart contracts can significantly improve production processes by automating routine operations and ensuring transparency and security of transactions

The isolated proteolytic domain of Escherichia coli ATP-dependent protease Lon exhibits the peptidase activity

AbstractSelective protein degradation is an energy-dependent process performed by high-molecular-weight proteases. The activity of proteolytic components of these enzymes is coupled to the ATPase activity of their regulatory subunits or domains. Here, we obtained the proteolytic domain of Escherichia coli protease Lon by cloning the corresponding fragment of the lon gene in pGEX-KG, expression of the hybrid protein, and isolation of the proteolytic domain after hydrolysis of the hybrid protein with thrombin. The isolated proteolytic domain exhibited almost no activity toward protein substrates (casein) but hydrolyzed peptide substrates (melittin), thereby confirming the importance of the ATPase component for protein hydrolysis. Protease Lon and its proteolytic domain differed in the efficiency and specificity of melittin hydrolysis

Виробництво м’ясних сиров’ялених снеків: перспективи та конкуренто-спроможність

The article presents the results of the study of consumer expectations on the example of the “standard” sample of meat dries snacks. The purpose of the work is to study consumer expectations of raw meat products and to study the competitiveness of this product on the Ukrainian market, as well as the impact of quality on this indicator. Nutrition is one of the main determinants of human health. In recent years there has been a disturbance of the nutrition structure due to changes in the rhythm of life and a decrease in the consumption of biologically valuable nutrition components. Unfortunately, the accelerated pace of life of a modern person makes her resort to food on the go. To satisfy this need people can have such products as snacks. Snacks, as a rule, are ideal for solving this problem – It is available natural dry products ready for use and packaged in individual packaging, which allows them to be used anywhere and in all conditions. Meat snack products quite recently appeared on the domestic market and attracted the attention of the consumer as a protein-containing product. The evaluation and comparison of the competitiveness of meat snacks presented on the consumer market of Kyiv with a “standard” sample has been carried out. The study was conducted using statistical methods of quality assessment. Roasted meat snacks are a new product on the market of Ukrainians, but their popularity is growing. With the necessary balance between the indicators of economy, safety and consumer desirable organoleptic indicators, the profitability of this segment of food production will only increase. The research of the competitiveness of meat snacks proves that the consumer is interested in their purchase, and therefore producers should pay attention to the development of this type of products.У статті наведені результати дослідження споживчих очікувань на прикладі “еталонного” зразка м’ясних сиров’ялених  снеків. Харчування – один із найголовніших факторів, що визначають здоров’я людини. В останні роки спостерігається порушення структури харчування, зумовлене зміною ритму життя і зниженням споживання біологічно цінних компонентів харчування. На жаль, прискорений темп життя сучасної людини, змушує її вдаватися до харчування на ходу. Задовольнити цю потребу людей можуть такі продукти як снеки. Снеки, як правило, ідеально підходять для вирішення цієї проблеми – це доступні натуральні сухі продукти, готові до вживання і розфасовані в індивідуальну упаковку, що дозволяє їх застосовувати в будь-якому місці і в будь-яких умовах. М’ясна снекова продукція досить недавно з’явилася на вітчизняному ринку і привернула до себе увагу споживача як білкововмісний продукт. Проведено оцінювання та порівняння конкурентоспроможності м’ясних снеків, які представлені на споживчому ринку м. Києва, з “еталонним” зразком. Дослідження проводилось з використанням статистичних методів оцінки якості. Сиров’ялені м’ясні снеки є новим продуктом на полицях українців, проте їх популярність набирає обертів. При дотриманні необхідного балансу між показниками економічності, безпечності та бажаними для споживача органолептичними показниками, рентабельність даного сегменту харчового виробництва буде лише зростати. Дослідження конкурентоспроможності м’ясних снеків доводить, що споживач зацікавлений в їх придбанні, а отже виробникам варто звернути увагу на розробку цього виду продукції

Female reproductive tract microbiome and early miscarriages

The review presents new data on the impact of the vaginal and uterine microbiome on the local immunity, including defense against sexually transmitted infections, and its association with other factors of miscarriage

Homeobox gene expression in acute myeloid leukemia is linked to typical underlying molecular aberrations

Background: Although distinct patterns of homeobox (HOX) gene expression have been described in defined cytogenetic and molecular subsets of patients with acute myeloid leukemia (AML), it is unknown whether these patterns are the direct result of transcriptional alterations or rather represent the differentiation stage of the leukemic cell. Method: To address this question, we used qPCR to analyze mRNA expression of HOXA and HOXB genes in bone marrow (BM) samples of 46 patients with AML and sorted subpopulations of healthy BM cells. These various stages of myeloid differentiation represent matched counterparts of morphological subgroups of AML. To further study the transcriptional alterations of HOX genes in hematopoiesis, we also analyzed gene expression of epigenetic modifiers in the subpopluations of healthy BM and leukemic cells. Results: Unsupervised hierarchical clustering divided the AMLs into five clusters characterized by the presence of prevalent molecular genetic aberrations. Notably, the impact of genotype on HOX gene expression was significantly more pronounced than that of the differentiation stage of the blasts. This driving role of molecular aberrations was best exemplified by the repressive effect of the PML-RARa fusion gene on HOX gene expression, regardless of the presence of the FLT3/ITD mutation. Furthermore, HOX gene expression was positively correlated with mRNA levels of histone demethylases (JMJD3 and UTX) and negatively correlated with gene expression of DNA methyltranferases. No such relationships were observed in subpopulations of healthy BM cells. Conclusion: Our results demonstrate that specific molecular genetic aberrations, rather than differentiation per se, underlie the observed differences in HOX gene expression in AML. Moreover, the observed correlations between epigenetic modifiers and HOX ex pression that are specific to malignant hematopoiesis, suggest their potential causal relationships.</p

Homeobox gene expression in acute myeloid leukemia is linked to typical underlying molecular aberrations

Background: Although distinct patterns of homeobox (HOX) gene expression have been described in defined cytogenetic and molecular subsets of patients with acute myeloid leukemia (AML), it is unknown whether these patterns are the direct result of transcriptional alterations or rather represent the differentiation stage of the leukemic cell. Method: To address this question, we used qPCR to analyze mRNA expression of HOXA and HOXB genes in bone marrow (BM) samples of 46 patients with AML and sorted subpopulations of healthy BM cells. These various stages of myeloid differentiation represent matched counterparts of morphological subgroups of AML. To further study the transcriptional alterations of HOX genes in hematopoiesis, we also analyzed gene expression of epigenetic modifiers in the subpopluations of healthy BM and leukemic cells. Results: Unsupervised hierarchical clustering divided the AMLs into five clusters characterized by the presence of prevalent molecular genetic aberrations. Notably, the impact of genotype on HOX gene expression was significantly more pronounced than that of the differentiation stage of the blasts. This driving role of molecular aberrations was best exemplified by the repressive effect of the PML-RARa fusion gene on HOX gene expression, regardless of the presence of the FLT3/ITD mutation. Furthermore, HOX gene expression was positively correlated with mRNA levels of histone demethylases (JMJD3 and UTX) and negatively correlated with gene expression of DNA methyltranferases. No such relationships were observed in subpopulations of healthy BM cells. Conclusion: Our results demonstrate that specific molecular genetic aberrations, rather than differentiation per se, underlie the observed differences in HOX gene expression in AML. Moreover, the observed correlations between epigenetic modifiers and HOX ex pression that are specific to malignant hematopoiesis, suggest their potential causal relationships.</p

АНАЛИЗ И ОЦЕНКА РЕЗУЛЬТАТОВ ФИНАНСОВО-ХОЗЯЙСТВЕННОЙ ДЕЯТЕЛЬНОСТИ ДЛЯ МИНИМИЗАЦИИ НАЛОГОВЫХ РИСКОВ ОРГАНИЗАЦИЙ

Below is the original author's approach to the companies' tax risks valuation based on the comparison of the tax and financial statements. Algorithm of the tax risks identification based on the criteria settled by the note of the Federal Tax Authority of Russian Federation from 17.07.2013 №АС-4-2/12722 "About tax authorities committees operation on legalisation of the tax base" is described. Model of the companies classification by tax risks based on the tax burden and specific cash flow is provided.Представлен оригинальный авторский подход к оценке налоговых рисков организаций, который основан на сопоставлении налоговой и бухгалтерской отчетности. Описан алгоритм выявления налоговых рисков по критериям, установленным письмом ФНС РФ от 17.07.2013 г. № АС-4-2/12722 «О работе комиссий налоговых органов по легализации налоговой базы». Представлена модель классификации организаций по налоговым рискам на основе сравнения налоговой нагрузки и удельного денежного потока