Delocalization power of global unitary operations on quantum information

We investigate how originally localized two pieces of quantum information represented by a tensor product of two unknown qudit states are delocalized by performing two-qudit global unitary operations. To characterize the delocalization power of global unitary operations on quantum information, we analyze the necessary and sufficient condition to deterministically relocalize one of the two pieces of quantum information to its original Hilbert space by using only LOCC. We prove that this LOCC one-piece relocalization is possible if and only if the global unitary operation is local unitary equivalent to a controlled-unitary operation. The delocalization power and the entangling power characterize different non-local properties of global unitary operations.Comment: 14 pages, 1 figur

Particle addition and subtraction as a test of bosonic quality

We propose a test to measure the bosonic quality of particles with respect to physical operations of single-particle addition and subtraction. We apply our test to investigate bosonic properties of composite particles made of an even number of fermions and suggest its experimental implementation. Furthermore, we discuss features of the processes of particle addition and subtraction in terms of optimal quantum operations.Comment: 5 page

Critical Accretion Rate for Triggered Star Formation

We have reexamined the similarity solution for a self-gravitating isothermal gas sphere and examined implication to star formation in a turbulent cloud. When parameters are adequately chosen, the similarity solution expresses an accreting isothermal gas sphere bounded by a spherical shock wave. The mass and radius of the sphere increases in proportion to the time, while the central density decreases in proportion to the inverse square of time. The similarity solution is specified by the accretion rate and the infall velocity. The accretion rate has an upper limit for a given infall velocity. When the accretion rate is below the upper limit, there exist a pair of similarity solutions for a given set of the accretion rate and infall velocity. One of them is confirmed to be unstable against a spherical perturbation. This means that the gas sphere collapses to initiate star formation only when the accretion rate is larger than the upper limit. We have also examined stability of the similarity solution against non-spherical perturbation. Non-spherical perturbations are found to be damped.Comment: 20 pages, 7 figures, accepted for publication in the Astrophysical Journal, part

Acetylcholine induces fibrogenic effects via M2/M3 ACh receptors in NASH and in primary human hepatic stellate cells

BACKGROUND: The parasympathetic nervous system (PNS), via neurotransmitter Acetylcholine (ACh), modulates fibrogenesis in animal models. However, the role of ACh in human hepatic fibrogenesis is unclear. AIMS: We aimed to determine the fibrogenic responses of human hepatic stellate cells (hHSC) to ACh and the relevance of the PNS in hepatic fibrosis in patients with non-alcoholic steatohepatitis (NASH). METHODS: Primary hHSC were analysed for synthesis of endogenous ACh and acetylcholinesterase (AChE), and gene expression of choline acetyltransferase (ChAT) and muscarinic acetylcholine receptors (mAChR). Cell proliferation and fibrogenic markers were analysed in hHSC exposed to ACh, Atropine (Atrop), Mecamylamine (Mec), methoctramine and 4-Diphenylacetoxy-N-methylpiperidine methiodide (4-DAMP). MAChR expression was analysed in human NASH scored for fibrosis. RESULTS: We observed that hHSC synthesise ACh and AChE, and express ChAT and M1-M5 mAChR. We also show that M2 was increased during NASH progression, while both M2 and M3 were found upregulated in activated hHSC. Furthermore, endogenous ACh is required for hHSC basal growth. Exogenous ACh resulted in hHSC hyperproliferation via mAChR and PI-3 K and MEK signalling pathways, as well as increased fibrogenic markers. CONCLUSION: We show that ACh regulates hHSC activation via M2 and M3 mAChR involving the PI-3 K and MEK pathways in vitro. Finally, we provide evidence that the PNS may be involved in human NASH fibrosis

Precise determination of atom configuration in partially disordered spinel compounds by HARECSX.

Electron channeling enhanced x-ray spectroscopy has been being widely used to determine ordered arrangement of component atoms in multinary inorganic or metallic crystals. Recent theoretical advancements in the modeling of characteristic x-ray emission by inelastic scattering of incident electrons under dynamical diffraction conditions has achieved remarkable progress, and it has enabled scientists to analyze the experimental intensity of x-ray emission in precise detail. In this study, the ion configuration in magnesium aluminate spinel (MgO{center_dot}nAl{sub 2}O{sub 3}) has been examined by measurements of characteristic x-ray emission as a function of incident electron beam direction at high angular resolution, a technique which we have termed HARECXS (high angular resolution electron channeling x-ray spectroscopy). This paper reports the results and emphasizes the applicability of HARECXS to partially disordered materials

Hepatic rhythmicity of endoplasmic reticulum stress is disrupted in perinatal and adult mice models of high-fat diet-induced obesity

We investigated the regulation of hepatic ER stress in healthy liver and adult or perinatally programmed diet-induced non-alcoholic fatty liver disease (NAFLD). Female mice were fed either obesogenic or control diet before mating, during pregnancy and lactation. Post-weaning, offspring from each maternal group were divided into either obesogenic or control diet. At six months, offspring were sacrificed at 4-h intervals over 24 h. Offspring fed obesogenic diets developed NAFLD phenotype, and the combination of maternal and offspring obesogenic diets exacerbated this phenotype. UPR signalling pathways (IREα, PERK, ATF6) and their downstream regulators showed different basal rhythmicity, which was modified in offspring exposed to obesogenic diet and maternal programming. The double obesogenic hit increased liver apoptosis measured by TUNEL staining, active caspase-3 and phospho-JNK and GRP78 promoter methylation levels. This study demonstrates that hepatic UPR is rhythmically activated. The combination of maternal obesity (MO) and obesogenic diets in offspring triggered altered UPR rhythmicity, DNA methylation and cellular apoptosis