Study on prediction of type 2 diabetes mellitus in undergraduate MBBS students: a cross-section study in a tertiary health center, Kolkata

Background: Diabetes, is now a leading cause of morbidity and mortality worldwide. Prevalence of type-2 diabetes in children and adolescents is rapidly increasing worldwide. Adolescence and early youth period has pivotal importance for young people with diabetes risk when they usually start learning about how to take responsibility. With this background, present study was done to find out the proportion of various risk factors and future risk of developing diabetes among MBBS undergraduates in Kolkata.Methods: This study was a cross-sectional institution based study done from 1st June to 18th June 2017. Data was collected by interviewing each respondent with the help of structured pre-designed pre-tested schedule, after which clinical examination for height, weight, waist and hip circumference, blood pressure and RBS were done. Out of 150 undergraduates, 130 agreed to participate. Data was analysed with R software.Results: Mean age of the students was 20.45years. 48.5% of them were either overweight or obese. Nearly half of them had waist circumference and waist hip ratio in risk group. Only 65 were normotensive and 7 had high random blood sugar (≥140 mg/dl). 6 students were in high risk group according to both IDRS (≥60) and ADA (≥5) risk score. 66 students were in moderate risk (30-50) group as per IDRS risk score.Conclusions: The simple and cost-effective IDRS could serve as a screening tool health worker to identify at risk individuals at the earliest and enable primary prevention by encouraging these students to modify their life-style

Dark Energy and the Statistical Study of the Observed Image Separations of the Multiply Imaged Systems in the CLASS Statistical Sample

The present day observations favour a universe which is flat, accelerated and composed of $\sim 1/3$ matter (baryonic + dark) and $\sim 2/3$ of a negative pressure component, usually referred to as dark energy or quintessence. The Cosmic Lens All Sky Survey (CLASS), the largest radio-selected galactic mass scale gravitational lens search project to date, has resulted in the largest sample suitable for statistical analyses. In the work presented here, we exploit observed image separations of the multiply imaged lensed radio sources in the sample. We use two different tests: (1) image separation distribution function $n(\Delta\theta)$ of the lensed radio sources and (2) {\dtheta}_{\mathrm{pred}} vs {\dtheta}_{\mathrm{obs}} as observational tools to constrain the cosmological parameters $w$ and \Om. The results are in concordance with the bounds imposed by other cosmological tests.Comment: 20 pages latex; Modified " Results and Discussion " section, new references adde

Recent advances in biosensors for detection of COVID-19 and other viruses

This century has introduced very deadly, dangerous, and infectious diseases to humankind such as the influenza virus, Ebola virus, Zika virus, and the most infectious SARS-CoV-2 commonly known as COVID-19 and have caused epidemics and pandemics across the globe. For some of these diseases, proper medications, and vaccinations are missing and the early detection of these viruses will be critical to saving the patients. And even the vaccines are available for COVID-19, the new variants of COVID-19 such as Delta, and Omicron are spreading at large. The available virus detection techniques take a long time, are costly, and complex and some of them generates false negative or false positive that might cost patients their lives. The biosensor technique is one of the best qualified to address this difficult challenge. In this systematic review, we have summarized recent advancements in biosensor-based detection of these pandemic viruses including COVID-19. Biosensors are emerging as efficient and economical analytical diagnostic instruments for early-stage illness detection. They are highly suitable for applications related to healthcare, wearable electronics, safety, environment, military, and agriculture. We strongly believe that these insights will aid in the study and development of a new generation of adaptable virus biosensors for fellow researchers

Recent advances in biosensors for detection of COVID-19 and other viruses

This century has introduced very deadly, dangerous, and infectious diseases to humankind such as the influenza virus, Ebola virus, Zika virus, and the most infectious SARS-CoV-2 commonly known as COVID-19 and have caused epidemics and pandemics across the globe. For some of these diseases, proper medications, and vaccinations are missing and the early detection of these viruses will be critical to saving the patients. And even the vaccines are available for COVID-19, the new variants of COVID-19 such as Delta, and Omicron are spreading at large. The available virus detection techniques take a long time, are costly, and complex and some of them generates false negative or false positive that might cost patients their lives. The biosensor technique is one of the best qualified to address this difficult challenge. In this systematic review, we have summarized recent advancements in biosensor-based detection of these pandemic viruses including COVID-19. Biosensors are emerging as efficient and economical analytical diagnostic instruments for early-stage illness detection. They are highly suitable for applications related to healthcare, wearable electronics, safety, environment, military, and agriculture. We strongly believe that these insights will aid in the study and development of a new generation of adaptable virus biosensors for fellow researchers

Imaging Multidimensional Therapeutically Relevant Circadian Relationships

Circadian clocks gate cellular proliferation and, thereby, therapeutically target availability within proliferative pathways. This temporal coordination occurs within both cancerous and noncancerous proliferating tissues. The timing within the circadian cycle of the administration of drugs targeting proliferative pathways necessarily impacts the amount of damage done to proliferating tissues and cancers. Concurrently measuring target levels and associated key pathway components in normal and malignant tissues around the circadian clock provides a path toward a fuller understanding of the temporal relationships among the physiologic processes governing the therapeutic index of antiproliferative anticancer therapies. The temporal ordering among these relationships, paramount to determining causation, is less well understood using two- or three-dimensional representations. We have created multidimensional multimedia depictions of the temporal unfolding of putatively causative and the resultant therapeutic effects of a drug that specifically targets these ordered processes at specific times of the day. The systems and methods used to create these depictions are provided, as well as three example supplementary movies

Imaging Multidimensional Therapeutically Relevant Circadian Relationships

Circadian clocks gate cellular proliferation and, thereby, therapeutically target availability within proliferative pathways. This temporal coordination occurs within both cancerous and noncancerous proliferating tissues. The timing within the circadian cycle of the administration of drugs targeting proliferative pathways necessarily impacts the amount of damage done to proliferating tissues and cancers. Concurrently measuring target levels and associated key pathway components in normal and malignant tissues around the circadian clock provides a path toward a fuller understanding of the temporal relationships among the physiologic processes governing the therapeutic index of antiproliferative anticancer therapies. The temporal ordering among these relationships, paramount to determining causation, is less well understood using two- or three-dimensional representations. We have created multidimensional multimedia depictions of the temporal unfolding of putatively causative and the resultant therapeutic effects of a drug that specifically targets these ordered processes at specific times of the day. The systems and methods used to create these depictions are provided, as well as three example supplementary movies

Atomic layer deposition of Pt@CsH_2PO_4 for the cathodes of solid acid fuel cells

Atomic layer deposition (ALD) has been used to apply continuous Pt films on powders of the solid acid CsH_2PO_4 (CDP), in turn, used in the preparation of cathodes in solid acid fuel cells (SAFCs). The film deposition was carried out at 150 °C using trimethyl(methylcyclopentadienyl)platinum (MeCpPtMe_3) as the Pt source and ozone as the reactant for ligand removal. Chemical analysis showed a Pt growth rate of 0.09 ± 0.01 wt%/cycle subsequent to an initial nucleation delay of 84 ± 20 cycles. Electron microscopy revealed the contiguous nature of the films prepared using 200 or more cycles. The cathode overpotential (0.48 ± 0.02 V at a current density of 200 mA/cm^2) was independent of Pt deposition amount beyond the minimum required to achieve these continuous films. The cell electrochemical characteristics were moreover extremely stable with time, with the cathode overpotentials increasing by no more than 10 mV over a 100 h period of measurement. Thus, ALD holds promise as an effective tool in the preparation of SAFC cathodes with high activity and excellent stability

Atomic layer deposition of Pt@CsH_2PO_4 for the cathodes of solid acid fuel cells

Atomic layer deposition (ALD) has been used to apply continuous Pt films on powders of the solid acid CsH_2PO_4 (CDP), in turn, used in the preparation of cathodes in solid acid fuel cells (SAFCs). The film deposition was carried out at 150 °C using trimethyl(methylcyclopentadienyl)platinum (MeCpPtMe_3) as the Pt source and ozone as the reactant for ligand removal. Chemical analysis showed a Pt growth rate of 0.09 ± 0.01 wt%/cycle subsequent to an initial nucleation delay of 84 ± 20 cycles. Electron microscopy revealed the contiguous nature of the films prepared using 200 or more cycles. The cathode overpotential (0.48 ± 0.02 V at a current density of 200 mA/cm^2) was independent of Pt deposition amount beyond the minimum required to achieve these continuous films. The cell electrochemical characteristics were moreover extremely stable with time, with the cathode overpotentials increasing by no more than 10 mV over a 100 h period of measurement. Thus, ALD holds promise as an effective tool in the preparation of SAFC cathodes with high activity and excellent stability

The contribution of N-rich stars to the Galactic stellar halo using APOGEE red giants

The contribution of dissolved globular clusters (GCs) to the stellar content of the Galactic halo is a key constraint on models for GC formation and destruction, and the mass assembly history of the Milky Way. Earlier results from APOGEE pointed to a large contribution of destroyed GCs to the stellar content of the inner halo, by as much as 25$\%$, which is an order of magnitude larger than previous estimates for more distant regions of the halo. We set out to measure the ratio between N-rich and normal halo field stars, as a function of distance, by performing density modelling of halo field populations in APOGEE DR16. Our results show that at 1.5 kpc from the Galactic Centre, N-rich stars contribute a much higher 16.8$^{+10.0}_{-7.0}$$\%$ fraction to the total stellar halo mass budget than the 2.7$^{+1.0}_{-0.8}$$\%$ ratio contributed at 10 kpc. Under the assumption that N-rich stars are former GC members that now reside in the stellar halo field, and assuming the ratio between first-and second-population GC stars being 1:2, we estimate a total contribution from disrupted GC stars of the order of 27.5$^{+15.4}_{-11.5}$$\%$ at r = 1.5 kpc and 4.2$^{+1.5}_{-1.3}$$\%$ at r = 10 kpc. Furthermore, since our methodology requires fitting a density model to the stellar halo, we integrate such density within a spherical shell from 1.5-15 kpc in radius, and find a total stellar mass arising from dissolved and/or evaporated GCs of $M_{\mathrm{GC,total}}$ = 9.6$^{+4.0}_{-2.6}$ $\times$ 10$^{7}$ M$\odot$.Comment: Paper accepted for Publication in MNRA