Effect of Isoteoline on Seizure Susceptibility in Pentylenetetrazole-Treated Mice

The present work was designed to examine the effect of isoteoline on neuronal excitability in mice. Isoteoline has previously been shown to behave as a S-HT2 antagonist in a number of experimental settings with results indicating possible selectivity of the compound for 5-HT2C receptors. These serotonergic receptors are implicated, amongst many other functions, in modulating seizure susceptibility. Mutant mice lacking 5-HT2C receptors have been shown to suffer spontaneous seizures and higher mortality. This has lead to the notion that serotonin may be involved in the pathogenesis of epilepsy. However, no 5-HT2 antagonist has sofar been shown to possess pro-convulsive activity. We used the model of pentylnetetrazole (PTZ)-induced seizures to assess the anticonvulsive effect of the 5-HT2C agonist chlorophenylpiperazine (mCPP). It proved to prevent significantly the clonic and tonic seizures induced by a sub-maximal dose of PTZ. 1ST which was expected if anything to act pro-convulsively was tested against PTZ at a dose equal to its ED50. No such effect was observed; on the contrary, a slight insignificant anticonvulsive tendency was noted. On the other hand, IST tended to antagonize the anticonvulsive effect of mCPP, but the effect failed to reach statistical significance. The results are discussed in the light of similar data from the literature concerning 5-HT2C antagonists. In addition, the failure of 1ST to significantly antagonize the protective effect of mCPP is sought to be explained, possibly by its dopaminomimetic activity

Effects of Isoteoline in Experimental Tests for Memory and Sedation in Mice

Isoteoline (IST) has been previously shown to possess anxiolytic activity in models of mice and rats. The aim of the present study was to examine this compound for potential memory-impairing and sedative effects. IST was compared with scopolamine and diazepam known for their anterograde amnesia, in respect to information acquisition. Diazepam served also as a sedative standard. Passive avoidance test was used to explore the effect of the drugs on the cognitive processes. Memory components such as acquisition, consolidation and retrieval were assessed depending on the time of drugs' administration relative to the training session and the retention session 24h later. We measured open field locomotion as an index of possible sedation. The results showed that IST was devoid of adverse effects on cognition. Unlike diazepam and scopolamine, IST tended to improve acquisition. It had no effect on memory consolidation and retrieval. IST did not reduce locomotion as well as thus differing from diazepam also in this respect. The lack of amnesic and sedative effects of IST adds favourably to its anxiolytic activity

Claremont Colleges Library Faculty Library Survey Summary Report: 2014

This report highlights findings from the Fall 2013 Faculty Library Survey with information from the Fall 2012 Ithaka survey included where relevant. The Fall 2012 Ithaka S+R Faculty Survey focused broadly on research and teaching practices as well as the dissemination, collecting, discovery, and access of research and teaching materials. The Fall 2013 Faculty Library survey was designed to gauge the Claremont Colleges faculty’s familiarity with, use of, and views about: a) Library educational services; b) student’s Information Literacy (IL) competencies; and c) Library collections. Both the Fall 2012 Ithaka and Fall 2013 Faculty Library surveys represent aspects of a larger environmental scanning and strategic planning process intended to give the library insight into the characteristics of its users

Claremont Colleges Student Survey (Spring 2014)

This survey was designed to understand how Claremont Colleges students use, perceive, and understand the Claremont Colleges Library, academic information technologies, and Information literacy skills. It was developed by Sara Lowe, Char Booth, and Maria Savova based on a survey Char Booth created and administered with the Council of Chief Librarians of California Community Colleges

Claremont Colleges Faculty Survey (Fall 2013)

This survey was designed to gauge the Claremont Colleges faculty’s familiarity with, use of, and views about two areas: a) Library educational services / Information Literacy competencies, and b) Library collections

2014 Student Library Survey Report

This survey was administered in response to a larger strategic planning process initiated by the Claremont Colleges Library (CCL). Building on the 2012 Student Library & Technology Survey and the 2013 Faculty Library Survey, the present survey is an attempt to gather longitudinal and comparative data from Claremont Colleges’ faculty and students. The present survey is based on a framework established by two prior investigations of local academic communities to inform library operations

EFFECT OF ISOTEOLINE IN ANIMAL MODELS PREDICTIVE OF ANTIDEPRESSANT ACTIVITY

Isoteoline, a compound of aporphine structure, was studied for antidepressant activity. Two animal models were used: the behavioral despair test and the clonidine-induced hypothermia. Isoteoline failed to alter the immobility time in rats subjected to forced swimming, but antagonized the immobility-reducing effect of desipramine, both after a single and multiple administration. In rats made hypothermic by i.p. injection of clonidine, Isoteoline did not antagonize the effect on rectal temperature, but rather accentuated it. The conclusion was made that Isoteoline was devoid of antidepressant activity. The results were analyzed in terms of previously demonstrated interactions of Isoteoline with subtypes of serotonergic receptors and were found to provide further evidence in support of these interactions

A Probabilistic model of meetings that combines words and discourse features

(c) 2008 IEEE. Personal use of this material is permitted. Permission from IEEE must be obtained for all other users, including reprinting/ republishing this material for advertising or promotional purposes, creating new collective works for resale or redistribution to servers or lists, or reuse of any copyrighted components of this work in other works.This is the author's accepted version of this article. The final published version can be found here: http://dx.doi.org/10.1109/TASL.2008.92586

Russian & Eastern European Studies Curriculum Map 2013-2014

This map displays degree requirements, courses, faculty information, clubs & organizations, and Library resources associated with Russian and Eastern European Studies across the seven Claremont Colleges (7Cs) for the 2013-14 academic year. It was compiled using public information drawn from Colleges websites, course schedules and catalogs, and the Claremont Colleges Library website. This project was completed as part of an IMLS Sparks! Ignition grant in 2013-14