314 research outputs found
Creating a Bidirectional Culture of Safety in Global Health Electives Via Comprehensive Safety Protocols
The economic and social impact of patient care attendants at Mulago national referral hospital, Kampala, Uganda
Pressure-induced phase transition in the electronic structure of palladium nitride
We present a combined theoretical and experimental study of the electronic
structure and equation of state (EOS) of crystalline PdN2. The compound forms
above 58 GPa in the pyrite structure and is metastable down to 11 GPa. We show
that the EOS cannot be accurately described within either the local density or
generalized gradient approximations. The Heyd-Scuseria-Ernzerhof
exchange-correlation functional (HSE06), however, provides very good agreement
with experimental data. We explain the strong pressure dependence of the Raman
intensities in terms of a similar dependence of the calculated band gap, which
closes just below 11 GPa. At this pressure, the HSE06 functional predicts a
first-order isostructural transition accompanied by a pronounced elastic
instability of the longitudinal-acoustic branches that provides the mechanism
for the experimentally observed decomposition. Using an extensive Wannier
function analysis, we show that the structural transformation is driven by a
phase transition of the electronic structure, which is manifested by a
discontinuous change in the hybridization between Pd-d and N-p electrons as
well as a conversion from single to triple bonded nitrogen dimers. We argue for
the possible existence of a critical point for the isostructural transition, at
which massive fluctuations in both the electronic as well as the structural
degrees of freedom are expected.Comment: 9 pages, 12 figures. Revised version corrects minor typographical
error
From Uncertainty Data to Robust Policies for Temporal Logic Planning
We consider the problem of synthesizing robust disturbance feedback policies
for systems performing complex tasks. We formulate the tasks as linear temporal
logic specifications and encode them into an optimization framework via
mixed-integer constraints. Both the system dynamics and the specifications are
known but affected by uncertainty. The distribution of the uncertainty is
unknown, however realizations can be obtained. We introduce a data-driven
approach where the constraints are fulfilled for a set of realizations and
provide probabilistic generalization guarantees as a function of the number of
considered realizations. We use separate chance constraints for the
satisfaction of the specification and operational constraints. This allows us
to quantify their violation probabilities independently. We compute disturbance
feedback policies as solutions of mixed-integer linear or quadratic
optimization problems. By using feedback we can exploit information of past
realizations and provide feasibility for a wider range of situations compared
to static input sequences. We demonstrate the proposed method on two robust
motion-planning case studies for autonomous driving
Coordinating community healthcare needs to local services in Paraiso, Dominican Republic through strategic assessment strategies
The effects of an interdisciplinary employment program on paid employment and mental health among persons with severe mental disorders
Purpose: This study evaluates the effects of the interdisciplinary employment program ‘Work As Best Care (WABC)’ on employment participation and mental health of persons with severe mental disorders.Methods: WABC is a ‘work first’ employment program for unemployed persons with severe mental disorders in which employment professionals work closely together with mental health professionals. In a longitudinal non-randomized controlled study, participants of WABC (n = 35) are compared with participants of the control group (n = 37), who received regular employment support. Participants were followed for 1 year and filled out questionnaires on individual characteristics and health at baseline, after 6 and 12 months. This information was enriched with monthly register data on employment status from 2015 until 2020. Difference-in-differences analyses were performed to investigate changes in employment participation among participants of WABC and the control group. A generalized linear mixed-effects model was used to compare changes in mental health (measured on 0–100 scale) between the two groups. Results: Before WABC, employment participation was 22.0%points lower among participants of WABC compared to the control group. After starting WABC, employment participation increased with 15.3%points per year among participants of WABC, compared to 5.6%points in the control group. Among all participants of WABC, no change in mental health was found (β 1.0, 95% CI − 3.4; 5.5). Only female participants of WABC showed a significant change in mental health (β 8.0, 95% CI 2.6; 13.4). Conclusion: To enhance employment participation of persons with severe mental disorders, an interdisciplinary ‘work-first’ approach in which professionals of employment services and mental health services work in close collaboration, is of paramount importance.</p
Gallid herpesvirus 3 SB-1 strain as a recombinant viral vector for poultry vaccination
Live herpesvirus-vectored vaccines are widely used in veterinary medicine to protect against many infectious diseases. In poultry, three strains of herpesvirus vaccines are used against Marek’s disease (MD). However, of these, only the herpesvirus of turkeys (HVT) has been successfully developed and used as a recombinant vaccine vector to induce protection against other avian viral diseases such as infectious bursal disease (IBD), Newcastle disease (ND) or avian influenza (AI). Although effective when administered individually, recombinant HVT vectors have limitations when combined in multivalent vaccines. Thus there is a need for developing additional viral vectors that could be combined with HVT in inducing protection against multiple avian diseases in multivalent vaccines. Gallid herpesvirus 3 (GaHV3) strain SB-1 is widely used by the poultry industry as bivalent vaccine in combination with HVT to exploit synergistic effects against MD. Here, we report the development and application of SB-1 as a vaccine vector to express the VP2 capsid antigen of IBD virus. A VP2 expression cassette was introduced into the SB-1 genome at three intergenic locations (UL3/UL4, UL10/UL11 and UL21/UL22) using recombineering methods on the full-length pSB-1 infectious clone of the virus. We show that the recombinant SB-1 vectors expressing VP2 induced neutralising antibody responses at levels comparable to that of commercial HVT-based VAXXITEKHVT+IBD vaccine. Birds vaccinated with the experimental recombinant SB-1 vaccine were protected against clinical disease after challenge with the very virulent UK661 IBDV isolate, demonstrating its value as an efficient viral vector for developing multivalent vaccines against avian diseases
The effects of an interdisciplinary employment program on paid employment and mental health among persons with severe mental disorders
Purpose: This study evaluates the effects of the interdisciplinary employment program ‘Work As Best Care (WABC)’ on employment participation and mental health of persons with severe mental disorders.Methods: WABC is a ‘work first’ employment program for unemployed persons with severe mental disorders in which employment professionals work closely together with mental health professionals. In a longitudinal non-randomized controlled study, participants of WABC (n = 35) are compared with participants of the control group (n = 37), who received regular employment support. Participants were followed for 1 year and filled out questionnaires on individual characteristics and health at baseline, after 6 and 12 months. This information was enriched with monthly register data on employment status from 2015 until 2020. Difference-in-differences analyses were performed to investigate changes in employment participation among participants of WABC and the control group. A generalized linear mixed-effects model was used to compare changes in mental health (measured on 0–100 scale) between the two groups. Results: Before WABC, employment participation was 22.0%points lower among participants of WABC compared to the control group. After starting WABC, employment participation increased with 15.3%points per year among participants of WABC, compared to 5.6%points in the control group. Among all participants of WABC, no change in mental health was found (β 1.0, 95% CI − 3.4; 5.5). Only female participants of WABC showed a significant change in mental health (β 8.0, 95% CI 2.6; 13.4). Conclusion: To enhance employment participation of persons with severe mental disorders, an interdisciplinary ‘work-first’ approach in which professionals of employment services and mental health services work in close collaboration, is of paramount importance.</p
A suggested prototype for assessing bone health
Background- Osteoporosis is becoming a health concern worldwide. Considering the fact that prevention plays an important role in reducing the burden of this silent disease and in view of the limited resources available, many countries have adopted certain programs to fight osteoporosis through shifting their attention towards at-risk individuals. The Iranian Multicenter Osteoporosis Study (IMOS) is one of these programs. The program aims to assess bone health and the prevalence of vitamin D deficiency in different parts of Iran with various altitudes, latitudes and lifestyle habits in a way that the results could be generalized to the country. Method- The present article presents the protocol used in the third phase of the study. It was designed based on the experiences gathered in the previous phases to overcome the shortcomings particularly subject loss. The questionnaire applied in this study was developed based on a thorough literature review of the risk factors and secondary causes of osteoporosis and was approved by an expert panel. It should be added that while the majority of the existing studies aim to study a certain aspect of osteoporosis, the present protocol provides the information needed for policy makers and researchers to study different osteoporosis-related issues. Conclusion- The authors believe the protocol, to be implemented with small modifications, can help policymakers in different parts of the world, particularly developing countries, gather accurate information on different aspects of bone health at the national level. © 2015, Academy of Medical Sciences of I.R. Iran. All rights reserved
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