385 research outputs found
Dysfunction of Neuromuscular Synapses in the Genetic Model of Alzheimer’s Disease
© 2018, Springer Science+Business Media, LLC, part of Springer Nature. The function of synaptic transmission and presynaptic vesicular cycle in the neuromuscular synapses of the diaphragm was studied in transgenic APP/PS1 mice (Alzheimer’s disease model). The decrease in the quantal content of end-plate potential, intense depression of the amplitude of terminal plate potentials under conditions of lasting high frequency stimulation (50 Hz), a drastic prolongation of the synaptic vesicle recycling time in APP/PS1 mice in comparison with wild type mice were detected. Manifest dysfunction of the neuromuscular synapses, caused by disordered neurosecretion and recycling of the synaptic vesicles in the presynaptic nerve endings, was detected in the Alzheimer’s disease model on transgenic APP/PS1 mice. The study supplemented the notions on the pathogenesis of Alzheimer’s disease as a systemic disease, while the detected phenomena could just partially explain the development of motor disorders in this disease
Self-similar solution of a nonsteady problem of nonisothermal vapour condensation on a droplet growing in diffusion regime
This paper presents a mathematically exact self-similar solution to the joint
nonsteady problems of vapour diffusion towards a droplet growing in a
vapour-gas medium and of removal of heat released by a droplet into a
vapour-gas medium during vapour condensation. An equation for the temperature
of the droplet is obtained; and it is only at that temperature that the
self-similar solution exists. This equation requires the constancy of the
droplet temperature and even defines it unambiguously throughout the whole
period of the droplet growth. In the case of strong display of heat effects,
when the droplet growth rate decreases significantly, the equation for the
temperature of the droplet is solved analytically. It is shown that the
obtained temperature fully coincides with the one that settles in the droplet
simultaneously with the settlement of its diffusion regime of growth. At the
obtained temperature of the droplet the interrelated nonsteady vapour
concentration and temperature profiles of the vapour-gas medium around the
droplet are expressed in terms of initial (prior to the nucleation of the
droplet) parameters of the vapour-gas medium. The same parameters are used to
formulate the law in accordance with which the droplet is growing in diffusion
regime, and also to define the time that passes after the nucleation of the
droplet till the settlement of diffusion regime of droplet growth, when the
squared radius of the droplet becomes proportionate to time. For the sake of
completeness the case of weak display of heat effects is been studied.Comment: 12 pages, 4 figure
Test of exotic scalar and tensor interactions in K_e3 decay using stopped positive kaons
The form factors of the decay K+ --> pi0 e+ nu (K_e3) have been determined
from the comparison of the experimental and Monte Carlo Dalitz distributions
containing about 10^5 K_e3 events. The following values of the parameters were
obtained: lambda_+ = 0.0278 +- 0.0017(stat) +- 0.0015(syst), f_S/f_+(0) =
0.0040 +- 0.0160(stat) +- 0.0067(syst) and f_T/f_+(0) = 0.019 +- 0.080(stat) +-
0.038(syst). Both scalar f_S and tensor f_T form factors are consistent with
the Standard Model predictions of zero values.Comment: 10 pages, 5 figures, contributed to the proceedings of NANP
Conference, Dubna, June 19-23, 200
The Role of Certain Species of Small Mammals in the Persistence of Natural Focality in the Territory of Forest-Steppe Zone of the Natural Tularemia Focus of the Stavropol Region
Epizootiological monitoring of the forest-steppe area of the natural tularemia focus in the Stavropol region has revealed that the role of particular species of small mammals in the persistence of natural tularemia focality is unequal. Epizootic activity of the focus in 1959-1970 was determined by the numerous species of rodents: Microtus arvalis , mice of Syvaemus genus and Mus musculus . In 1972-2010 there occurred significant changes in the grouping of the main tularemia agent carriers under the influence of strong anthropogenic pressure. Nowadays the leading role is played by the widely-spread and subsistent mice of Sylvaemus genus and C. suaveolens , the latter ones being responsible for 31.2 % of overall, isolated from small mammals, tularemia agent strains. In addition to this, epizootic significance of M. arvalis has greatly changed. Index of strains isolated from field vole has lowered from 55.3 up to 28.4. Numbers of M. arvalis and Mus musculus are continuously on the low level, which is due to the absence of favorable breeding conditions. It reduces their impact on the persistence of natural focality in the territory under surveillance significantly
Local modes, phonons, and mass transport in solid He
We propose a model to treat the local motion of atoms in solid He as a
local mode. In this model, the solid is assumed to be described by the Self
Consistent Harmonic approximation, combined with an array of local modes. We
show that in the bcc phase the atomic local motion is highly directional and
correlated, while in the hcp phase there is no such correlation. The correlated
motion in the bcc phase leads to a strong hybridization of the local modes with
the T phonon branch, which becomes much softer than that obtained
through a Self Consistent Harmonic calculation, in agreement with experiment.
In addition we predict a high energy excitation branch which is important for
self-diffusion. Both the hybridization and the presence of a high energy branch
are a consequence of the correlation, and appear only in the bcc phase. We
suggest that the local modes can play the role in mass transport usually
attributed to point defects (vacancies). Our approach offers a more overall
consistent picture than obtained using vacancies as the predominant point
defect. In particular, we show that our approach resolves the long standing
controversy regarding the contribution of point defects to the specific heat of
solid He.Comment: 10 pages, 10 figure
A Survey of Satisfiability Modulo Theory
Satisfiability modulo theory (SMT) consists in testing the satisfiability of
first-order formulas over linear integer or real arithmetic, or other theories.
In this survey, we explain the combination of propositional satisfiability and
decision procedures for conjunctions known as DPLL(T), and the alternative
"natural domain" approaches. We also cover quantifiers, Craig interpolants,
polynomial arithmetic, and how SMT solvers are used in automated software
analysis.Comment: Computer Algebra in Scientific Computing, Sep 2016, Bucharest,
Romania. 201
Investigation of the Chaotic Dynamics of an Electron Beam with a Virtual Cathode in an External Magnetic Field
The effect of the strength of the focusing magnetic field on chaotic dynamic
processes occurring inan electron beam with a virtual cathode, as well as on
the processes whereby the structures form in the beamand interact with each
other, is studied by means of two-dimensional numerical simulations based on
solving a self-consistent set of Vlasov-Maxwell equations. It is shown that, as
the focusing magnetic field is decreased,the dynamics of an electron beam with
a virtual cathode becomes more complicated due to the formation andinteraction
of spatio-temporal longitudinal and transverse structures in the interaction
region of a vircator. The optimum efficiency of the interaction of an electron
beam with the electromagnetic field of the vircator isachieved at a
comparatively weak external magnetic field and is determined by the
fundamentally two-dimensional nature of the motion of the beam electrons near
the virtual cathode.Comment: 12 pages, 8 figure
NMR Study of Disordered Inclusions in the Quenched Solid Helium
Phase structure of rapidly quenched solid helium samples is studied by the
NMR technique. The pulse NMR method is used for measurements of spin-lattice
and spin-spin relaxation times and spin diffusion coefficient
for all coexisting phases. It was found that quenched samples are two-phase
systems consisting of the hcp matrix and some inclusions which are
characterized by and values close to those in liquid phase. Such
liquid-like inclusions undergo a spontaneous transition to a new state with
anomalously short times. It is found that inclusions observed in both the
states disappear on careful annealing near the melting curve. It is assumed
that the liquid-like inclusions transform into a new state - a glass or a
crystal with a large number of dislocations. These disordered inclusions may be
responsible for the anomalous phenomena observed in supersolid region.Comment: 10 pages, 3 figure
Measurement of the Pion Form Factor in the Energy Range 1.04-1.38 GeV with the CMD-2 Detector
The cross section for the process is measured in the
c.m. energy range 1.04-1.38 GeV from 995 000 selected collinear events
including 860000 events, 82000 events, and 33000
events. The systematic and statistical errors of measuring the
pion form factor are equal to 1.2-4.2 and 5-13%, respectively.Comment: 5 pages, 2 figure
Norbornadiene as a Universal Substrate for Organic and Petrochemical Synthesis
A wide range of rare polycyclic hydrocarbons can be obtained through catalytic processes involving norbornadiene (NBD). The problem of selectivity is crucial for such reactions. The feasibility of controlling
selectivity and reaction rate has been shown for cyclic dimerization, co-dimerization, isomerization and allylation of NBD. Kinetic rules have been scrutinized. Consistent mechanisms have been proposed. Factors
affecting directions of the reactions and allowing us to obtain individual stereoisomers quantitatively, have been established. A series of novel unsaturated compounds has been synthesized; they incorporate a set of double bonds with different reactivity and can find an extremely wide range of applications
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