Surface deformations and gravity changes caused by pressurized finite ellipsoidal cavities

We develop quasi-analytical solutions for the surface deformation field and gravity changes due to the pressurization of a finite (triaxial) ellipsoidal cavity in a half-space. The solution is in the form of a non-uniform distribution of triaxial point sources within the cavity. The point sources have the same aspect ratio, determined by the cavity shape, while their strengths and spacing are determined in an adaptive manner, such that the net point-source potency per unit volume is uniform. We validate and compare our solution with analytical and numerical solutions. We provide computationally efficient MATLAB codes tailored for source inversions. This solution opens the possibility of exploring the geometry of shallow magma chambers for potential deviations from axial symmetry

Measurement of genetic parameters within and between breeder flocks of Arian broiler lines using randomly amplified polymorphic DNA (RAPD) markers

The present study was carried out in an attempt to detect the genetic variation within and between four populations of commercial broiler lines using RAPD markers. Thirteen out of twenty random markers which were amplified and generating stable and reproducible bands were selected for genotyping of birds in each broiler lines. The average number of diagnostic bands per primer was 8.08 with an average number of 6.96 polymorphic bands across all breed groups. The highest (94%) and the lowest (73.5%) percentage of polymorphic bands were found within sampled birds of Arian C and D lines, respectively. Among the studied broiler lines, the highest genetic uniformity was found in line A, while the greatest within population genetic diversity was found in line C. Estimation of polymorphic loci, Nei’s gene diversity and intra-population uniformity indices suggested that genetic diversities within Arian commercial lines is high. The four strains of broiler lines clustered into two main groups using UPGMA procedure. In the first main group, the closest genetic distance was found between A and B strains, which were first clustered together and then with birds of C strain. The second main group includes birds from D strain. The mean coefficient of gene differentiation (Gst = 0.368) value reflected a high level of population differences. In total, sixty three RAPD bands were found to be strain dependent specific. Therefore, in order to design new diagnostic primers more effective in genetic discrimination among studied lines, unique bands should be cloned and sequenced.Key words: Genetic variation, broiler lines, polymorphism, random amplified polymorphic DNA markers

The prevalence of Human Papilloma Virus (HPV) infection in the oligospermic and azoospermic men

Background: Human papilloma virus (HPV) infection is one of the most common sexually transmitted diseases that affects men like women and infected cutaneous and mucosal squamous epithelium. The aim of the present study was to determine the prevalence of HPV in the semen of oligospermic, azoospermic and normal patients. Methods: From June 2012 to June 2013, a total of 90 individuals were enrolled in this cross sectional comparative study. The participants were classified into three groups (oligospermia, azoosprmia and normal). This classification was based on a new WHO reference values for human semen characteristics published on 2010. After extraction of DNA from specimens L1 gene of HPV was amplified by nested polymerase chain reaction (Nested-PCR) and the PCR products of positive specimens were genotyped using INNO-LiPA HPV Genotyping Extra assay. Results: Among 50 confirmed oligospermic male, 15 were HPV DNA positive (30). In azoospemic group we had 8 HPV DNA positive (40) and in normal group just 3 of 20(15) samples were positive. Statistical assessment was done with SPSS v.15. Chi-square test showed no significant relationship between 3 groups results. Based on independent samples t-test, we found statistical significant relationship for sperm count (p<0.05) and sperm motility (slow) (p<0.05) in oligospermic group positive samples compared with negative. In the present study, 13 HPV genotypes were detected among positive samples. HPV genotypes 16, 45 in the high risk group and 6,11,42 in the low risk group were more frequent than the others. Conclusion: The current study shows that HPV infection can affect on sperm count and motility and decrease count of sperm cell and decrease motility capability of these cells

Drainage of a deep magma reservoir near Mayotte inferred from seismicity and deformation

The dynamics of magma deep in the Earth’s crust are difficult to capture by geophysical monitoring. Since May 2018, a seismically quiet area offshore of Mayotte in the western Indian Ocean has been affected by complex seismic activity, including long-duration, very-long-period signals detected globally. Global Navigation Satellite System stations on Mayotte have also recorded a large surface deflation offshore. Here we analyse regional and global seismic and deformation data to provide a one-year-long detailed picture of a deep, rare magmatic process. We identify about 7,000 volcano-tectonic earthquakes and 407 very-long-period seismic signals. Early earthquakes migrated upward in response to a magmatic dyke propagating from Moho depth to the surface, whereas later events marked the progressive failure of the roof of a magma reservoir, triggering its resonance. An analysis of the very-long-period seismicity and deformation suggests that at least 1.3 km3 of magma drained from a reservoir of 10 to 15 km diameter at 25 to 35 km depth. We demonstrate that such deep offshore magmatic activity can be captured without any on-site monitoring

Inhibition of MicroRNA miR-222 with LNA Inhibitor Can Reduce Cell Proliferation in B Chronic Lymphoblastic Leukemia

MicroRNAs (miRNAs) are small regulatory molecules that negatively regulate gene expression by base-pairing with their target mRNAs. miRNAs have contribute significantly to cancer biology and recent studies have demonstrated the oncogenic or tumor-suppressing role in cancer cells. In many tumors up-regulation miRNAs has been reported especially miR-222 has been shown to be up-regulated in B chronic lymphocytic leukemia (B-CLL). In this study we assessed the effected inhibition of miR-222 in cell viability of B-CLL. We performed inhibition of mir-222 in B-CLL cell line (183-E95) using locked nucleic acid (LNA) antagomir. At different time points after LNA-anti-mir-222 transfection, miR-222 quantitation and cell viability were assessed by qRT-real time polymerase chain reaction and MTT assays. The data were analyzed by independent t test and one way ANOVA. Down-regulation of miR-222 in B-CLL cell line (183-E95) with LNA antagomir decreased cell viability in B-CLL. Cell viability gradually decreased over time as the viability of LNA-anti-mir transfected cells was <47 % of untreated cells at 72 h post-transfection. The difference in cell viability between LNA-anti-miR and control groups was statistically significant (p < 0.042). Based on our findings, the inhibition of miR-222 speculate represent a potential novel therapeutic approach for treatment of B-CLL

Towards coordinated regional multi-satellite InSAR volcano observations:results from the Latin America pilot project

Within Latin America, about 319 volcanoes have been active in the Holocene, but 202 of these volcanoes have no seismic, deformation or gas monitoring. Following the 2012 Santorini Report on satellite Earth Observation and Geohazards, the Committee on Earth Observation Satellites (CEOS) developed a 4-year pilot project (2013-2017) to demonstrate how satellite observations can be used to monitor large numbers of volcanoes cost-effectively, particularly in areas with scarce instrumentation and/or difficult access. The pilot aims to improve disaster risk management (DRM) by working directly with the volcano observatories that are governmentally responsible for volcano monitoring as well as with the international space agencies (ESA, CSA, ASI, DLR, JAXA, NASA, CNES). The goal is to make sure that the most useful data are collected at each volcano following the guidelines of the Santorini report that observation frequency is related to volcano activity, and to communicate the results to the local institutions in a timely fashion. Here we highlight how coordinated multi-satellite observations have been used by volcano observatories to monitor volcanoes and respond to crises. Our primary tool is measurements of ground deformation made by Interferometric Synthetic Aperture Radar (InSAR), which have been used in conjunction with other observations to determine the alert level at these volcanoes, served as an independent check on ground sensors, guided the deployment of ground instruments, and aided situational awareness. During this time period, we find 26 volcanoes deforming, including 18 of the 28 volcanoes that erupted – those eruptions without deformation were less than 2 on the VEI scale. Another 7 volcanoes were restless and the volcano observatories requested satellite observations, but no deformation was detected. We describe the lessons learned about the data products and information that are most needed by the volcano observatories in the different countries using information collected by questionnaires. We propose a practical strategy for regional to global satellite volcano monitoring for use by volcano observatories in Latin America and elsewhere to realize the vision of the Santorini report

A Review on Modelling of the Maximum Lagging Current Test Method of Salient Pole Synchronous Machines

Quadrature-axis reactance for various reasons comes into account as one of the most important parameters of salient pole synchronous machine. There are several common standard methods for measuring this parameter that also have been explained with some details in the standards, scientific papers and text books. One of these methods is the maximum lagging current test that is done simply at no-load, having a three phase voltage source and applying very low power even for a high power machine. How this experiment is done is described at some references such as the books related to electrical machinery. This paper presents a detail analysis and description of the test and some simulation results regarding the performance of the machine during pole-slipping. It is shown when the reversal field current is increased very slowly, the transient of the pole-slipping commences at load angle equal to 45 degrees or by a better language at 225 instead of zero which is the common opinion of almost all the previously published literatures. In this paper, a realistically developed analysis of the test is presented applying appropriate assumptions. The maximum lagging current test is then simulated applying a small salient pole machine with the rated 31.5 kVA using Matlab/Simulink. Some simulation results are illustrated that prove correctness and validity of the new analysis and the proof described by the present paper

Analysis of different material theories used in a FE model of a lumbar segment motion

In this study, a nonlinear poroelastic model of intervertebral disc as an infrastructure was developed. Moreover, a new element was defined consisting a disc (Viscoelastic Euler Beam Element) and a vertebra (Rigid Link) as a unit element. Using the new element, three different viscoelastic finite element models were prepared for lumbar motion segment (L4/L5). Prolonged loading (short-term and longterm creep) and cyclic loading were applied to the models and the results were compared with results of in vivo tests. Simplification of the models by using the new element leads to reduction of the runtime of the models in dynamic analyses to few minutes without losing the accuracy in the results