Prevalence of Zoonotic Intestinal Helminths of Canids in Moghan Plain, Northwestern Iran

Background: The present study was aimed to elucidate the status of intestinal hel­minth infec­tions in canids of Moghan Plain, northwestern Iran.Methods: Eighty-five intestine samples from dead or shot wild canids, 59 fecal samples from sheepdogs and 5 from red foxes were collected from 2006 to 2008 and examined in Parasitology department of Pasteur Institute of Iran.Results: Generally, adult worms, larvae, and eggs of 13 species of various parasitic hel­minths were recovered. Necropsy examinations showed that 96.47% animals harbored at least one helminth species. The prevalence of different species in necropsy were Mesoces­toides sp. 84.7%, Rictolaria spp. 55.3%, Macranthorhynchus hirudinaceus 45.9%, Toxocara canis 43.5%, Toxas­caris spp. 35.3%, Joyeuxiella sp. 34.1%; hook­worms; 22.4%, Taenia spp. 11.8%, Alaria spp. 2.4% and Dipylidium caninum 1.2%. Be­sides, eggs belonging to 10 species of parasitic helminths were identified in 46 fecal sam­ples and generally, 30.9% of samples harbored eggs of at least one helminth species.Conclusion: The high prevalence of various helminth infections among canids in Mog­han plain and contamination of environment by helminths eggs may increase the risk of infection for native peo­ple

Probable hepatic capillariosis and hydatidosis in an adolescent from the late Roman period buried in Amiens (France)

Two calcified objects recovered from a 3rd to 4th-century grave of an adolescent in Amiens (Northern France) were identified as probable hydatid cysts. By using thin-section petrographic techniques, probable Calodium hepaticum (syn. Capillaria hepatica) eggs were identified in the wall of the cysts. Human hepatic capillariosis has not been reported from archaeological material so far, but could be expected given the poor level of environmental hygiene prevalent in this period. Identification of tissue-dwelling parasites such as C. hepaticum in archaeological remains is particularly dependent on preservation conditions and taphonomic changes and should be interpreted with caution due to morphological similarities with Trichuris sp. eggs

Dark energy constraints from quasar observations

Recent measurements of the parameters of the Concordance Cosmology Model ($\Lambda$CDM) done in the low-redshift Universe with Supernovae Ia/Cepheids, and in the distant Universe done with Cosmic Microwave Background (CMB) imply different values for the Hubble constant (67.4 $\pm$ 0.5 km s$^{-1}$ Mpc$^{-1}$ from Planck vs 74.03 $\pm$ 1.42 km s$^{-1}$ Mpc$^{-1}$, Riess et al. 2019). This Hubble constant tension implies that either the systematic errors are underestimated, or the $\Lambda$CDM does not represent well the observed expansion of the Universe. Since quasars - active galactic nuclei - can be observed in the nearby Universe up to redshift z $\sim$ 7.5, they are suitable to estimate the cosmological properties in a large redshift range. Our group develops two methods based on the observations of quasars in the late Universe up to redshift z$\sim$4.5, with the objective to determine the expansion rate of the Universe. These methods do not yet provide an independent measurement of the Hubble constant since they do not have firm absolute calibration but they allow to test the $\Lambda$CDM model, and so far no departures from this model were found.Comment: 6 pages, 2 figures, contribution to the Proceedings of the 100 years of the Polish Physical Society Congress, 16-18 October 2020, Warsaw, Poland. http://info.ifpan.edu.pl/APP

Multiwavelength study of extreme variability in LEDA 1154204: A changing-look event in a type 1.9 Seyfert

Context. Multiwavelength studies of transients in actively accreting supermassive black holes have revealed that large-amplitude variability is frequently linked to significant changes in the optical spectra -- a phenomenon referred to as changing-look AGN (CLAGN). Aim. In 2020, the Zwicky Transient Facility detected a transient flaring event in the type-1.9 AGN 6dFGS~gJ042838.8-000040, wherein a sharp increase in magnitude of $\sim$0.55 and $\sim$0.3 in the $g$- and $r$-bands, respectively, occurred over $\sim$40 days. Spectrum Roentgen Gamma (SRG)/eROSITA also observed the object in X-rays as part of its all-sky survey, but only after the flare had started decaying. Methods. We performed a three-year, multiwavelength follow-up campaign of the source to track its spectral and temporal characteristics. This campaign included multiple ground-based facilities for optical spectroscopic monitoring and space-based observatories including \textit{XMM-Newton} and \textit{Swift} for X-ray and UV observations. Results. An optical spectrum taken immediately after the peak revealed a changing-look event wherein the source had transitioned from type 1.9 to 1, with the appearance of a double-peaked broad H$\beta$ line and a blue continuum, both absent in an archival spectrum from 2005. The X-ray emission exhibits dramatic flux variation: a factor of $\sim$17, but with no spectral evolution, as the power-law photon index remained $\sim$1.9. There is no evidence of a soft X-ray excess. Overall the object exhibits no apparent signatures of a tidal disruption event. Conclusions. The transient event was likely triggered by a disk instability in a pre-existing accretion flow, culminating in the observed multi-wavelength variability and CLAGN event.Comment: 34 pages, 24 figures, Submitted to Astronomy & Astrophysic

Wavelength-resolved Reverberation Mapping of quasar CTSC30.10: Dissecting MgII and FeII emission regions

We present the results of the reverberation monitoring aimed at MgII broad line and FeII pseudocontinuum for the luminous quasar CTS C30.10 (z = 0.90052) with the Southern African Large Telescope covering the years 2012-2021. We aimed at disentangling the MgII and UV FeII variability and the first measurement of UV FeII time delay for a distant quasar. We used several methods for time-delay measurements and determined both FeII and MgII time delays as well as performed a wavelength-resolved time delay study for a combination of MgII and FeII in the 2700 - 2900 \AA restframe wavelength range. We obtain the time delay for MgII of $275.5^{+12.4}_{-19.5}$ days in the rest frame, while for FeII we have two possible solutions of $270.0^{+13.8}_{-25.3}$ days and $180.3^{+26.6}_{-30.0}$ in the rest frame. Combining this result with the old measurement of FeII UV time delay for NGC 5548 we discuss for the first time the radius-luminosity relation for UV FeII with the slope consistent with $0.5$ within uncertainties. Since FeII time delay has a shorter time-delay component but lines are narrower than MgII, we propose that the line delay measurement is biased towards the BLR part facing the observer, with the bulk of the Fe II emission may arise from the more distant BLR region, one that is shielded from the observer.Comment: 22 pages, 19 Figures, 6 Tables, Submitted to Astronomy and Astrophysics, Comments are welcom

Wavelength-resolved reverberation mapping of intermediate redshift quasars HE 0413-4031 and HE 0435-4312: Dissecting Mg II, optical Fe II, and UV Fe II emission regions

We present the wavelength-resolved reverberation mapping (RM) of combined MgII and UV FeII broad-line emissions for two intermediate redshifts (z$\sim$1), luminous quasars - HE 0413-4031 and HE 0435-4312, monitored by the SALT and 1-m class telescopes between 2012-2022. Through this technique, we aim to disentangle the Mg II and FeII emission regions and to build a radius-luminosity relation for UV FeII emission, which has so far remained unconstrained. Several methodologies have been applied to constrain the time delays for total MgII and FeII emissions. In addition, this technique is performed to quantify the inflow or outflow of broad-line region gas around the supermassive black hole and to disentangle the emission/emitting regions from lines produced in proximity to each other. The mean total FeII time delay is nearly equal to the mean total Mg II time delay for HE 0435-4312 suggesting a co-spatiality of their emissions. However, in HE 0413-4031, the mean FeII time delay is found to be longer than the mean MgII time delay, suggesting that FeII is produced at longer distances from the black hole. The UV Fe II R-L relation is updated with these two quasars and compared with the optical FeII relation, which suggests that the optical FeII region is located further than the UV FeII by a factor of 1.7-1.9 i.e. $R_{\rm FeII-opt}\sim(1.7-1.9)R_{\rm FeII-UV}$. We detected a weak pattern in the time delay vs. wavelength relation, suggesting that the MgII broad-line originates a bit closer to the SMBH than the UV FeII, however, the difference is not very significant. Comparison of MgII, UV, and optical FeII R-L relations suggests that the difference may be larger for lower-luminosity sources, possibly with the MgII emission originating further from the SMBH. In the future, more RM data will be acquired to put better constraints on these trends, in particular the UV FeII R-L relation.Comment: 24 pages, 16 figures, 5 tables, Accepted for publication in A&A, in Pres

Current status of clinical outcome measures in inclusion body myositis: a systematised review

OBJECTIVES: Sporadic inclusion body myositis (IBM) is a debilitating idiopathic inflammatory myopathy (IIM) which affects hand function, ambulation, and swallowing. There is no approved pharmacological therapy for IBM, and there is a lack of suitable outcome measure to assess the effect of an intervention. The IBM scientific interest group under IMACS reviewed the previously used outcome measures in IBM clinical studies to lay the path for developing a core set of outcome measures in IBM. METHODS: In this systematised review, we have extracted all outcome measures reported in IBM clinical studies to determine what measures were being used and to assess the need for optimising outcome measures in IBM. RESULTS: We found 13 observational studies, 17 open-label clinical trials, and 15 randomised control trials (RCTs) in IBM. Six-minute walk distance, IBM-functional rating scale (IBM-FRS), quantitative muscle testing, manual muscle testing, maximal voluntary isometric contraction testing, and thigh muscle volume measured by MRI were used as primary outcome measures. Twelve different outcome measures of motor function were used in IBM clinical trials. IBM-FRS was the most used measure of functionality. Swallowing function was reported as a secondary outcome measure in only 3 RCTs. CONCLUSIONS: There are inconsistencies in using outcome measures in clinical studies in IBM. The core set measures developed by the IMACS group for other IIMs are not directly applicable to IBM. As a result, there is an unmet need for an IBM-specific core set of measures to facilitate the evaluation of new potential therapeutics for IBM

Masonry compressive strength prediction using artificial neural networks

The masonry is not only included among the oldest building materials, but it is also the most widely used material due to its simple construction and low cost compared to the other modern building materials. Nevertheless, there is not yet a robust quantitative method, available in the literature, which can reliably predict its strength, based on the geometrical and mechanical characteristics of its components. This limitation is due to the highly nonlinear relation between the compressive strength of masonry and the geometrical and mechanical properties of the components of the masonry. In this paper, the application of artificial neural networks for predicting the compressive strength of masonry has been investigated. Specifically, back-propagation neural network models have been used for predicting the compressive strength of masonry prism based on experimental data available in the literature. The comparison of the derived results with the experimental findings demonstrates the ability of artificial neural networks to approximate the compressive strength of masonry walls in a reliable and robust manner.- (undefined

Thermally Responsive Amphiphilic Conetworks and Gels Based on Poly(N‑isopropylacrylamide) and Polyisobutylene

Novel amphiphilic conetworks (APCN) consisting of thermoresponsive poly(N-isoproplyacrylamide) (PNiPAAm) cross-linked by hydrophobic methacrylate-telechelic polyisobutylene (MA-PIB-MA) were successfully synthesized in a broad composition range. The resulting PNiPAAm-l-PIB conetworks (“l” stands for “linked by”) were obtained by radical copolymerization of NiPAAm with MA-PIB-MA in tetrahydrofuran, a cosolvent for all the components. Low amounts of extractables substantiated efficient network formation. The composition dependent two glass transition temperatures (Tg) by DSC analysis indicate microphase separation of the cross-linked components without mixed phases. It was found that the PNiPAAm-l-PIB conetworks are uniformly swellable in both water and n-hexane; i.e., these new materials behave either as hydrogels or as hydrophobic gels in aqueous or nonpolar media, respectively. The uniform swelling in both polar and nonpolar solutes indicates cocontinuous (bicontinuous) phase morphology. The equilibrium swelling degrees (R) depend on composition, that is, the higher the PIB content, the lower the R in water and the higher in n-hexane. The PNiPAAm phase keeps its thermoresponsive behavior in the conetworks as shown by significant decrease of the swelling degree in water between 20 and 35 °C. The lower critical solubility temperature (LCST) values determined by DSC are found to decrease from 34.1 °C (for the pure PNiPAAm homopolymer) to the range of 25–28 °C in the conetworks, and the extent of the LCST decrease is proportional with the PIB content. Deswelling-swelling, i.e., heating–cooling, cycle indicates insignificant hysteresis in these new thermoresponsive materials. This indicates that PNiPAAm-l-PIB conetworks with predetermined and thermoresponsive swelling behavior can be designed and utilized in several advanced applications on the basis of results obtained in the course of this study