Study of the associations between polymorphic markers rs1800629 TNFα, rs909253 Ltα, rs767455 TNFR1, rs1061624 TNFR2 and the development of type 2 diabetes = Изучение ассоциаций полиморфных маркеров генов факторов некроза опухоли и их рецепторов rs1800629 TNFα, rs909253 Ltα, rs767455 TNFR1, rs1061624 TNFR2 с формированием сахарного диабета 2 типа

To study the association between polymorphic genetic markers, tumor necrosis factors and their receptors (rs 1800629 TNFα, rs 909253 Ltα, rs 767455 TNFR1, rs 1061624 TNFR2) and the development of type 2 diabetes (T2D) among the population of the Central Black Earth Region of Russi

Improvement of information support for formation of management reporting on the example of the activities of an energy company

The purpose of the study is to develop a system for generating management reporting on the production activities of an energy company on the SAP Business Objects Platform. To build a reporting system, the following tasks has been set and solved: the conceptual and datalogical models of the data warehouse were created, data areas have been selected from the general data model, the data warehouse has been designed and developed, universes for report groups have been created, a mechanism for integrating data with the data warehouse has been implemented.The paper analyses the information and technological infrastructure of an energy company as well as formulates the basic requirements for the system being created for generating reporting. Two main subsystems have been designed: data storage and integration. The process of implementing the designed subsystems in physical form has been described using the appropriate software products: SAP Hana, SAP Universe Designer, SAP Data Services, SAP Business Intelligence.Thanks to the configured system through the corporate data bus, a relatively simple data integration mechanism became possible. In its information and technological architecture, the company managed to simulate an acceptable data warehouse model and set up the appropriate data flows. A complex data warehouse model has been implemented, and a convenient platform for further data processing has been provided. A clear data integration scheme is configured using SAP Data Services, with the ability to scale and configure the data loading schedule. The developed system has been put into operation and is used by employees to make management decisions within the framework of their professional activities

Application of fuzzy modeling in the evaluation of crisis state of enterprises

The features of the proposed fuzzy model for assessing the crisis state of enterprises have been disclosed. The MATLAB software environment has been selected as the environment for building a fuzzy output system. In the model of a fuzzy assessment of the crisis state of enterprises, the following input linguistic variables have been highlighted: the relative level of financial status, the probability of bankruptcy, the level of information security, the level of innovation potential. The terms of the input variables and the result variable have been described. The rule base for fuzzy inference system has been formulated. The results of modeling the assessment of the crisis state of enterprises have been represented by a fuzzy inference procedure

IMPROVING INFORMATION SUPPORT OF CRISIS MANAGEMENT BY ENTERPRISES ON THE BASIS OF USING COMMUNICATION TOOLS OF THE TECHNOLOGICAL PLATFORM

Information support of crisis management requires the creation of a communication infrastructure, based on the program-target method, within which technological standards and profiles are formed – technological platforms. The information support of the crisis management of enterprises, based on the use of communication tools of the technological platform, as an interface of the innovative infrastructure, allowing increase the efficiency of the information component of the enterprise management system, has been improved in the paper. Based on the technological platform, new research and production cooperations, innovation clusters will be formed, which will allow overcome the crisis state of enterprises

Effective resistance to powdery mildew in Aegilops L. accessions

Background. Powdery mildew (Blumeria graminis (DC.) E.O. Speer f. sp. tritici Em. Marchal) is widespread and harmful in all regions of bread wheat cultivation. Severe development of powdery mildew leads to a decrease in the number and weight of grains. Growing resistant cultivars is the most environmentally friendly and economically profitable method to protect wheat from the disease. Development of such cultivars requires a search for new donors of effective genes controlling the resistance. To expand the genetic diversity of wheat for resistance to B. graminis, wild relatives of Triticum aestivum L., including Aegilops L. spp., are widely used. The aim of this work was to characterize seven Aegilops spp. for effective seedling and adult plant resistance to powdery mildew.Materials and methods. The material of the study consisted of 437 accessions representing 7 Aegilops spp. (Ae. speltoides Tausch, Ae. caudata L., Ae. biuncialis Vis., Ae. tauschii Coss., Ae. cylindrica Host, Ae. crassa Boiss. and Ae. ventricosa Tausch) from the collection of the N.I. Vavilov All-Russian Institute of Plant Genetic Resources (VIR, St. Petersburg). Juvenile resistance was studied when the seedlings were inoculated with the agent of powdery mildew under controlled laboratory conditions; the adult plant resistance, after artificial inoculation of the plants and under natural infection in the fields of Pushkin and Pavlovsk Laboratories of VIR. Complex populations of the B. graminis agent were used for inoculation. The types of response to infection were scored 10 days after inoculation according to a conventional scale.Results and conclusions. As a result of the tests, susceptibility to powdery mildew was shown in all Aegilops accessions of the D-genome group; all the studied representatives of Ae. speltoides, Ae. caudata and Ae. biuncialis were highly resistant to powdery mildew

Investigation of the structure and microhardness of Mo-Fe-C coatings obtained by the electron beam injected in the atmosphere

In this work 'Mo-Fe-C' coatings fabricated on medium carbon steel by non-vacuum electron beam cladding were investigated. The structure of coatings and transition zones were studied by scanning electron microscopy (SEM). It was shown that an increase of Fe percentage in the cladding mixture led to a decrease of the eutectic volume fraction in the coating and was accompanied by the formation of the gradient structure between the coating and a substrate material. Measurements of microhardness in the cross section of samples revealed that the cladding of a 'Mo-C powder mixture contributed to a 4.5-fold increase of microhardness

Peculiarities of self-diffusion of alkane molecules in kaolinite

Self-diffusion of alkanes in kaolinite has been explored by pulsed field gradient nuclear magnetic resonance. The concentration dependences of average self-diffusion coefficient (SDC) of liquid have been studied in the wide temperature interval (T=253-383 K). The translational mobility of alkane molecules in kaolinite was shown to have some specific peculiarities. An anomalous rise was found in the average self-diffusion coefficient of the liquid as its content in kaolinite decreased. To explain this we should introduce a new "gas-like" state for the diffusant, whose mobility exceeds that of pure liquid. The possibility of the existence of such a state is explained by kaolinite's ability to increase the specific surface area of the induced liquid. Analysis of a shape of the spin-echo diffusion attenuation leads one to suppose that there are heterogeneities in the medium's porous space. © 1991 Springer

Investigation of the structure and microhardness of Mo-Fe-C coatings obtained by the electron beam injected in the atmosphere

In this work 'Mo-Fe-C' coatings fabricated on medium carbon steel by non-vacuum electron beam cladding were investigated. The structure of coatings and transition zones were studied by scanning electron microscopy (SEM). It was shown that an increase of Fe percentage in the cladding mixture led to a decrease of the eutectic volume fraction in the coating and was accompanied by the formation of the gradient structure between the coating and a substrate material. Measurements of microhardness in the cross section of samples revealed that the cladding of a 'Mo-C powder mixture contributed to a 4.5-fold increase of microhardness

ANALYSIS AND FORECASTING THE DYNAMICS OF ADVERTISING BOTS ACTIVITY

When introducing a new product or service to the market, a manufacturer or retailer is faced with the need to develop a promotion strategy. Taking into account the recent trends in e-commerce and social media marketing, it makes sense to evaluate the possibility of borrowing promotion strategies from producers of abstract, potentially  monetized electronic content. The article considers the activity of advertising bots using the example of the social network Facebook. The paper carries out an autocorrelation analysis of the observation results and reveals the frequency of automated requests to the user by advertising bots. The authors construct an autoregressive model of the dynamics of the activity of advertising bots and verbalize Facebook’s strategy to increase traffic to the  information space controlled by the social network

Blood saving possibilities in delivering patients with placenta increta

According to the results of systematic reviews of WHO, maternal mortality associated with massive bleeding almost reached 30% and has no tendency to decrease. Among the causes of massive obstetric hemorrhage, the most challenging ones are uterine hypotension and morbidity adherence placenta. Most severe complication for placentation is placenta increta in the uterine wall. Over the past 50 years, the number of cases with morbidity adherence placenta has increased tenfold. By all indications, this pathology has taken on the character of an epidemic and is one of the main causes for massive blood loss and blood transfusion, as well as peripartum hysterectomy. For surgical hemostasis in this pathology we apply X-ray vascular methods (temporary balloon occlusion of large vessels, vascular embolization), ligation of the iliac, uterine, ovarian arteries, various versions of distal hemostasis, including the use of uterine turnstiles, intrauterine and vaginal cylinders, compression sutures. However, data confirming the advantage of any specified methods are not enough. The risk of massive bleeding is high while using any of these methods. The article analyzes the blood saving methods existing at the present stage and possibility of these methods usage in obstetrics. Besides, we describe efficacy and safety of their use in massive blood loss, including the surgical treatment of morbidity adherence placenta