ORGANIZATION OF ALPHA-GLOBIN GENES AND MESSENGER-RNA TRANSLATION IN SUBJECTS CARRYING HEMOGLOBIN HASHARON (ALPHA-47 ASP -] HIS) FROM THE FERRARA REGION (NORTHERN ITALY)

In subjects carrying the haemoglobin Hasharon mutation (alpha 47 replaced by His), originally from the delta of the Po river (Northern Italy), the concentration of the alpha-globin variant has been evaluated and found to be approximately 32%, a value definitely higher than that reported for the same mutant haemoglobin in other regions. Restriction enzyme analysis has been carried out on the DNA from these subjects; the data obtained indicate the presence of three alpha-globin genes per diploid cell. Family studies further show that the two normal genes are located on one chromosome and the Hasharon gene on the other. The origin of the single alpha-gene in the Hasharon-carrying subjects of the Ferrara region is discussed in connection with their haematological and biosynthetic data

ALPHA-THALASSEMIA TRAIT IN THE REGION OF FERRARA

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