670 research outputs found
A numerical study of the smile effect in implied volatilities induced by a nonlinear feedback model
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The Affordable Care Act and State Charities Regulators
The Patient Protection and Affordable Care Act of 2010 (the “Affordable Care Act”) was enacted almost three years ago in March 2010. Certain of its provisions became effective shortly after enactment, and others have been ramping up in advance of the full implementation of most of the remaining provisions of the Affordable Care Act on January 1, 2014. The Affordable Care Act is probably one of, if not the most, comprehensive reform of the healthcare sector, which represents the largest percentage of this nation’s gross domestic product. Because of the extent of the reforms, the depth of impact on the entire healthcare system, and the costs and increased revenues associated with the Affordable Care Act, numerous challenges will be presented to state charities regulators as implementation of the Affordable Care Act continues to take place.
This paper will focus on the intersection between the federal healthcare reforms enacted as part of the Affordable Care Act and state charities regulators. Part II discusses the duty of care and oversight issues concerning compliance with the new section 501(r) requirements applicable to nonprofit and governmental hospitals that are or seek tax exemption under section 501(c)(3). Part III focuses on the dynamics of a consolidating marketplace for hospitals and health systems and the expected mergers, acquisitions and other transactions that are taking place and will take place in the coming years in response to or as a result of the law changes contained in the Affordable Care Act. Finally, with the increased funding that will result from full implementation of the Affordable Care Act, there will be greater competition for an increasingly scarce commodity – physicians. Part IV discusses how nonprofit hospitals may be compelled to push the limits of the anti-kickback and self-referral laws, thereby creating financial exposures for the hospitals and concomitant questions about compliance with fiduciary duties of oversight as the Delaware Supreme Court spelled out in the CareMark litigation
Early suppression of lymphoproliferative response in dogs with natural infection by Leishmania infantum.
Dogs are the domestic reservoirs of zoonotic visceral leishmaniasis caused by Leishmania
infantum. Early detection of canine infections evolving to clinically patent disease may be
important to leishmaniasis control. In this study we firstly investigated the peripheral blood
mononuclear cell (PBMC) response to leishmanial antigens and to polyclonal activators
concanavalin A, phytohemagglutinin and pokeweed mitogen, of mixed-breed dogs with natural
L. infantum infection, either in presymptomatic or in patent disease condition, compared to healthy
animals. Leishmania antigens did not induce a clear proliferative response in any of the animals
examined. Furthermore, mitogen-induced lymphocyte proliferation was found strongly reduced not
only in symptomatic, but also in presymptomatic dogs suggesting that the cell-mediated immunity
is suppressed in progressive canine leishmaniasis. To test this finding, naive Beagle dogs were
exposed to natural L. infantum infection in a highly endemic area of southern Italy. Two to 10
months after exposure all dogs were found to be infected by Leishmania, and on month 2 of
exposure they all showed a significant reduction in PBMC activation by mitogens. Our results
indicate that suppression of the lymphoproliferative response is a common occurrence in dogs
already at the beginning of an established leishmanial infection. # 1999 Elsevier Science B.V. All
rights reserved
OFF LABEL USE OF POWER INJECTABLE DOUBLE LUMEN PICCS FOR APHERESIS AND HEMODIAFILTRATION IN NEONATES AND CHILDREN
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