158 research outputs found
Efficacy and safety of ITS fentanyl given directly after tramadol to patients with cancer related pain (based on FEN-POL-2 trial)
Immune checkpoint inhibitors in the first-line treatment of metastatic small-cell lung cancer
Small-cell lung cancer is the most aggressive form of lung cancer. Most patients are diagnosed at a late disease stage when the prognosis is poor. The treatment algorithm for small-cell lung cancer remained unchanged for years, with chemotherapy as the first-line option. However, progress has been made with the recent development of immune checkpoint inhibitors, two of which — atezolizumab and durvalumab — have been approved in combination with chemotherapy as first-line treatment for advanced small-cell lung cancer. This review presents detailed data concerning the efficacy and safety of atezolizumab and durvalumab from both registration trials and real-world studies, as well as the results of clinical trials of other immune checkpoints inhibitors. Finally, the issue of identifying biomarkers to predict the efficacy of immunochemotherapy is discussed
In addition to: "Diagnosis and treatment of breast cancer. Recommendations of the Polish Union of Oncology" (Nowotwory J Oncol 2003; 53: 300-324)
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