Formulation Development and Evaluation of Valsartan Film Coated Tablets

Solid medicaments may be administered orally as powders, pills, cachets, capsules or tablets. These dosage forms contain a quantity of drug which is given as a single unit and they are known collectively as solid unit dosage forms, even in the case of sustained action preparations which, technically, contain the equivalent of several normal doses of drug .The stringent formulation requirements of modern medicaments, the many advantages of tablet and capsule medication, coupled with expanding health services and the commitment need for large-scale economic manufacture, have led to a steady decline in the prescribing of powders and pills. Tablets and capsules, on the other hand, currently account for well over two third of the total number and cost of medicines produced all over the world. The valsartan film coated tablets have been developed with direct compression method and it was compared with that of marketed product. The powder blend were subject to various physical characteristics tests such as bulk density, tapped density, Hausners ratio, compressibility index and core tablets were evaluated for weight variation, hardness, thickness, disintegration time and the results were within specification. In-vitro dissolution profile of developed formula was compared with marketed product and drug release profile of formula 8 was found to be matched with marketed product. The combination of superdisintegrants, crosscarmellose and cropovidone was shown faster disintegration rate. The optimized batch tablets were packed in HDPE bottle and performed stability studies at 40°C/75%RH. Stability samples were evaluated initially and upto three months. All the results were found to be satisfactory. Hence the designed and developed formula was stable. Valsartan film coated tablet developed in the present work was found to be pharmaceutically equivalent to marketed product

Securing Manets By Using An Intrusion Detection System (Eaack)

MANET arrangement may diverge depending on its application from a small static network that is extremely power inhibited to a large-scale, mobile, highly dynamic network. Every node works both as a transmitter and a receiver. Nodes converse directly with each other when they are both within the same communication range. Otherwise they depend on their neighbours to relay messages. Industrial remote access and control via wireless networks are flattering more and more popular these days. One of the chief advantages of wireless networks is its capability to permit data communication between different parties and still maintain their mobility. This communication is incomplete to the range of transmitters. This means that two nodes cannot communicate with each other when the distance between the two nodes is further than the communication range of their own. MANET solves this problem by allowing intermediate nodes to rely data transmission.   In this case detection should be focused as another part before an attacker can damage the structure of the system

N- Graphene Derivatives from Papaya Seeds: Synthesis and Chemistry

A two-step synthesis of nitrogen containing graphene (N-graphene) from papaya seeds is reported here. The preparation of N-graphene from a non-graphitic nitrogen containing precursor, without doping is really a challenging task. However, when papaya seeds were pyrolyzed at 250 oC temperature for 2 hrs, it led to the formation of N-GO without any additional oxidizing agent. Further, N-GO was converted to Nr-GO in presence of thiourea as a reducing agent. The synthesized N-GO was found to remove 82 % of iron from ground water

Lipidomics and Redox Lipidomics Indicate Early Stage Alcohol-Induced Liver Damage.

Alcoholic fatty liver disease (AFLD) is characterized by lipid accumulation and inflammation and can progress to cirrhosis and cancer in the liver. AFLD diagnosis currently relies on histological analysis of liver biopsies. Early detection permits interventions that would prevent progression to cirrhosis or later stages of the disease. Herein, we have conducted the first comprehensive time-course study of lipids using novel state-of-the art lipidomics methods in plasma and liver in the early stages of a mouse model of AFLD, i.e., Lieber-DeCarli diet model. In ethanol-treated mice, changes in liver tissue included up-regulation of triglycerides (TGs) and oxidized TGs and down-regulation of phosphatidylcholine, lysophosphatidylcholine, and 20-22-carbon-containing lipid-mediator precursors. An increase in oxidized TGs preceded histological signs of early AFLD, i.e., steatosis, with these changes observed in both the liver and plasma. The major lipid classes dysregulated by ethanol play important roles in hepatic inflammation, steatosis, and oxidative damage. Conclusion: Alcohol consumption alters the liver lipidome before overt histological markers of early AFLD. This introduces the exciting possibility that specific lipids may serve as earlier biomarkers of AFLD than those currently being used