379 research outputs found
Effect of Dietary Fats on Oxidative-Antioxidative Status of Blood in Rats
This study was performed to examine the effect of different fat sources, lard, sunflower oil (SO), and fish oil (FO) in high-fat and low-fat diet on reactive oxygen species generation by blood phagocytes, glutathione redox status in erythrocytes, and total plasma antioxidant ability in rats. Whole blood chemiluminescence (CL) did not differ between three low-fat fed groups. However, baseline and phorbol myristate acetate (PMA)-stimulated CL in blood of high-lard fed rats were lower than in low-lard and high-SO fed animals. Phagocyte-stimulated oxidative burst was higher in rats fed high-SO diet than in those fed low-SO and high-FO diets. The highest level of oxidize glutathione (GSSH), the lowest reduce glutathione (GSH)/GSSG ratio in erythrocytes, and the highest plasma activity to reduce ferric ions were observed in rats fed both diets contaning linoleic acid-rich sunflower oil compared to animals fed the corresponding energy from other fats. 1,1-diphenyl-2-picrylhydrazyl radical scavenging activity of plasma was lower in high-lard and high-FO fed rats compared to the corresponding low-fat diets, and the lowest in low-FO fed rats among low-fat fed animals. We presume from our results that linoleic acid may have dual effect, prooxidative in blood cells but maintaining total antioxidant plasma ability
Post‐traumatic stress disorder and birthweight: methodological challenges
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/89463/1/j.1471-0528.2011.03200.x.pd
Shear-induced quench of long-range correlations in a liquid mixture
A static correlation function of concentration fluctuations in a (dilute)
binary liquid mixture subjected to both a concentration gradient and uniform
shear flow is investigated within the framework of fluctuating hydrodynamics.
It is shown that a well-known long-range correlation at
large wave numbers crosses over to a weaker divergent one for wave numbers
satisfying , while an asymptotic shear-controlled
power-law dependence is confirmed at much smaller wave numbers given by , where , , and are the
mass concentration, the rate of the shear, the mass diffusivity and the
kinematic viscosity of the mixture, respectively. The result will provide for
the first time the possibility to observe the shear-induced suppression of a
long-range correlation experimentally by using, for example, a low-angle light
scattering technique.Comment: 8pages, 2figure
Hydrodynamic fluctuations in the Kolmogorov flow: Linear regime
The Landau-Lifshitz fluctuating hydrodynamics is used to study the
statistical properties of the linearized Kolmogorov flow. The relative
simplicity of this flow allows a detailed analysis of the fluctuation spectrum
from near equilibrium regime up to the vicinity of the first convective
instability threshold. It is shown that in the long time limit the flow behaves
as an incompressible fluid, regardless of the value of the Reynolds number.
This is not the case for the short time behavior where the incompressibility
assumption leads in general to a wrong form of the static correlation
functions, except near the instability threshold. The theoretical predictions
are confirmed by numerical simulations of the full nonlinear fluctuating
hydrodynamic equations.Comment: 20 pages, 4 figure
Stability of scaling regimes in developed turbulence with weak anisotropy
The fully developed turbulence with weak anisotropy is investigated by means
of renormalization group approach (RG) and double expansion regularization for
dimensions . Some modification of the standard minimal substraction
scheme has been used to analyze stability of the Kolmogorov scaling regime
which is governed by the renormalization group fixed point. This fixed point is
unstable at ; thus, the infinitesimally weak anisotropy destroyes above
scaling regime in two-dimensional space. The restoration of the stability of
this fixed point, under transition from to has been demonstrated
at borderline dimension . The results are in qualitative agreement
with ones obtained recently in the framework of the usual analytical
regularization scheme.Comment: 23 pages, 2 figure
Long-range correlations in non-equilibrium systems: Lattice gas automaton approach
In systems removed from equilibrium, intrinsic microscopic fluctuations
become correlated over distances comparable to the characteristic macroscopic
length over which the external constraint is exerted. In order to investigate
this phenomenon, we construct a microscopic model with simple stochastic
dynamics using lattice gas automaton rules that satisfy local detailed balance.
Because of the simplicity of the automaton dynamics, analytical theory can be
developed to describe the space and time evolution of the density fluctuations.
The exact equations for the pair correlations are solved explicitly in the
hydrodynamic limit. In this limit, we rigorously derive the results obtained
phenomenologically by fluctuating hydrodynamics. In particular, the spatial
algebraic decay of the equal-time fluctuation correlations predicted by this
theory is found to be in excellent agreement with the results of our lattice
gas automaton simulations for two different types of boundary conditions.
Long-range correlations of the type described here appear generically in
dynamical systems that exhibit large scale anisotropy and lack detailed
balance.Comment: 23 pages, RevTeX; to appear in Phys. Rev.
Ethanol Impairs Estrogen Receptor Signaling Resulting in Accelerated Activation of Senescence Pathways, Whereas Estradiol Attenuates the Effects of Ethanol in Osteoblasts
Epidemiological and animal studies have suggested that chronic alcohol consumption is a major risk factor for osteoporosis. Using bone from cycling female rats infused chronically with ethanol (EtOH) in vivo and osteoblastic cells in vitro, we found that EtOH significantly increased estrogen receptor α (ERα) and β (ERβ) mRNA and ERα protein levels. Treatment with 17β-estradiol (E2) in vivo and in vitro interfered with these effects of EtOH on bone and osteoblastic cells. ERα agonist propylpyrazoletriol (PPT) and ERβ agonist diarylpropionitrile (DPN) attenuated EtOH-induced ERα and ERβ gene overexpression, respectively. Similar to the ER antagonist ICI 182780, EtOH blocked nuclear translocation of ERα-ECFP in the presence of E2 in UMR-106 osteoblastic cells. EtOH also downregulated ERE-luc reporter activity. On the other hand, EtOH by itself upregulated some common ERα- and ERβ-mediated genes apparently by an ER-independent pathway. EtOH also transactivated the luciferase activity of the p21 promoter region independent of additional exogenous ERα, activated p21 and p53, and stimulated senescence-associated β-galactosidase activity in rat stromal osteoblasts. E2 treatment attenuated these EtOH actions. We conclude that inhibitory cross-talk between EtOH and E2 in osteoblasts on ERs, p53/p21, and cell senescence provides a pathophysiologic mechanism underlying bone loss and the protective effects of estrogens in alcohol-exposed females
A model for the atomic-scale structure of a dense, nonequilibrium fluid: the homogeneous cooling state of granular fluids
It is shown that the equilibrium Generalized Mean Spherical Model of fluid
structure may be extended to nonequilibrium states with equation of state
information used in equilibrium replaced by an exact condition on the two-body
distribution function. The model is applied to the homogeneous cooling state of
granular fluids and upon comparison to molecular dynamics simulations is found
to provide an accurate picture of the pair distribution function.Comment: 29 pages, 11 figures Revision corrects formatting of the figure
Formula diet alters small intestine morphology, microbial abundance and reduces VE-cadherin and IL-10 expression in neonatal porcine model
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