The Magnetic Ordering of the 3d Wigner Crystal

Using Path Integral Monte Carlo, we have calculated exchange frequencies as electrons undergo ring exchanges of 2, 3 and 4 electrons in a ``clean'' 3d Wigner crystal (bcc lattice) as a function of density. We find pair exchange dominates and estimate the critical temperature for the transition to antiferromagnetic ordering to be roughly $1 \times 10^{-8}$Ry at melting. In contrast to the situation in 2d, the 3d Wigner crystal is different from the solid bcc 3He in that the pair exchange dominates because of the softer interparticle potential. We discuss implications for the magnetic phase diagram of the electron gas

Giant Intrinsic Spin and Orbital Hall Effects in Sr2MO4 (M=Ru,Rh,Mo)

We investigate the intrinsic spin Hall conductivity (SHC) and the d-orbital Hall conductivity (OHC) in metallic d-electron systems, by focusing on the t_{2g}-orbital tight-binding model for Sr2MO4 (M=Ru,Rh,Mo). The conductivities obtained are one or two orders of magnitude larger than predicted values for p-type semiconductors with 5% hole doping. The origin of these giant Hall effects is the ``effective Aharonov-Bohm phase'' that is induced by the d-atomic angular momentum in connection with the spin-orbit interaction and the inter-orbital hopping integrals. The huge SHC and OHC generated by this mechanism are expected to be ubiquitous in multiorbital transition metal complexes, which pens the possibility of realizing spintronics as well as orbitronics devices.Comment: 5 pages, accepted for publication in PR

Spin Hall effect in Sr2RuO4 and transition metals (Nb,Ta)

We study the intrinsic spin Hall conductivity (SHC) and the $d$-orbital Hall conductivity (OHC) in metallic $d$-electron systems based on the multiorbital tight-binding model. The obtained Hall conductivities are much larger than that in $p$-type semiconductors. The origin of these huge Hall effects is the "effective Aharonov-Bohm phase" induced by the signs of inter-orbital hopping integrals as well as atomic spin-orbit interaction. Huge SHC and OHC due to this mecahnism is ubiquitous in multiorbital transition metals.Comment: 4 pages, 3 figures, Proceedings of SNS conference in Sendai, 200

Leading Temperature Corrections to Fermi Liquid Theory in Two Dimensions

We calculate the basic parameters of the Fermi Liquid: the scattering vertex, the Landau interaction function, the effective mass, and physical susceptibilities for a model of two-dimensional (2D) fermions with a short ranged interaction at non-zero temperature. The leading temperature dependences of the spin components of the scattering vertex, the Landau function, and the spin susceptibility are found to be linear. T-linear terms in the effective mass and in the ``charge-sector''- quantities are found to cancel to second order in the interaction, but the cancellation is argued not to be generic. The connection with previous studies of the 2D Fermi-Liquid parameters is discussed.Comment: 4 pages, 1 figur

Spinal cord vascular degeneration impairs duloxetine penetration

Introduction: Chronic pain is a prevalent physically debilitating health-related morbidity. Frontline analgesics are inadequate, providing only partial pain relief in only a proportion of the patient cohort. Here, we explore whether alterations in spinal cord vascular perfusion are a factor in reducing the analgesic capability of the noradrenaline reuptake inhibitor, duloxetine. Method: An established rodent model of spinal cord vascular degeneration was used. Endothelial-specific vascular endothelial growth factor receptor 2 knockout mouse was induced via hydroxytamoxifen administered via intrathecal injection. Duloxetine was administered via intraperitoneal injection, and nociceptive behavioural testing was performed in both WT and VEGFR2KO mice. LC-MS/MS was performed to explore the accumulation of duloxetine in the spinal cord in WT and VEGFR2KO mice. Results: Spinal cord vascular degeneration leads to heat hypersensitivity and a decline in capillary perfusion. The integrity of noradrenergic projections (dopa - hydroxylase labelled) in the dorsal horn remained unaltered in WT and VEGFR2KO mice. There was an association between dorsal horn blood flow with the abundance of accumulated duloxetine in the spinal cord and analgesic capacity. In VEGFR2KO mice, the abundance of duloxetine in the lumbar spinal cord was reduced and was correlated with reduced anti-nociceptive capability of duloxetine. Discussion: Here, we show that an impaired vascular network in the spinal cord impairs the anti-nociceptive action of duloxetine. This highlights that the spinal cord vascular network is crucial to maintaining the efficacy of analgesics to provide pain relief

Insulator-to-metal transition in Kondo insulators under strong magnetic field

Magnetization curve and changes of the single-particle excitation spectra by magnetic field are calculated for the periodic Anderson model at half-filling in infinite spatial dimension by using the exact diagonalization method. It is found that the field-induced insulator-to-metal transition occurs at a critical field $H_c$, which is of the order of the single ion Kondo temperature. The transition is of first order, but could be of second order in the infinite system size limit. These results are compared with the experiments on the Kondo insulator YbB$_{12}$.Comment: 11 pages, REVTEX, no figures; 7 figures available on request; To appear in Phys. Rev. B, Mar.15, 199

Giant Extrinsic Spin Hall Effect due to Rare-Earth Impurities

We investigate the extrinsic spin Hall effect in the electron gas model due to magnetic impurities, by focusing on Ce- and Yb-impurities. In the dilute limit, the skew scattering term dominates the side jump term. For Ce-impurities, the spin Hall angle $\alpha_{\rm SH}$ due to skew scattering is given by $-8\pi\sin\delta_2/7$, where $\delta_2 (\ll 1)$ is the phase shift for$d (l=2)$ partial wave. Since $\alpha_{\rm SH}$ reaches $O(10^{-1})$ if \delta_2 \simge 0.03, the spin Hall effect is anticipated to be considerable in metals with rare-earth impurities. The giant extrinsic SHE originates from the large orbital angular momentum, which is also significant for the intrinsic SHE.Comment: 5 pages, 3 figures, to be published in New Journal of Physic

Human Galectin-9 Is a Potent Mediator of HIV Transcription and Reactivation.

Identifying host immune determinants governing HIV transcription, latency and infectivity in vivo is critical to developing an HIV cure. Based on our recent finding that the host factor p21 regulates HIV transcription during antiretroviral therapy (ART), and published data demonstrating that the human carbohydrate-binding immunomodulatory protein galectin-9 regulates p21, we hypothesized that galectin-9 modulates HIV transcription. We report that the administration of a recombinant, stable form of galectin-9 (rGal-9) potently reverses HIV latency in vitro in the J-Lat HIV latency model. Furthermore, rGal-9 reverses HIV latency ex vivo in primary CD4+ T cells from HIV-infected, ART-suppressed individuals (p = 0.002), more potently than vorinostat (p = 0.02). rGal-9 co-administration with the latency reversal agent "JQ1", a bromodomain inhibitor, exhibits synergistic activity (p<0.05). rGal-9 signals through N-linked oligosaccharides and O-linked hexasaccharides on the T cell surface, modulating the gene expression levels of key transcription initiation, promoter proximal-pausing, and chromatin remodeling factors that regulate HIV latency. Beyond latent viral reactivation, rGal-9 induces robust expression of the host antiviral deaminase APOBEC3G in vitro and ex vivo (FDR<0.006) and significantly reduces infectivity of progeny virus, decreasing the probability that the HIV reservoir will be replenished when latency is reversed therapeutically. Lastly, endogenous levels of soluble galectin-9 in the plasma of 72 HIV-infected ART-suppressed individuals were associated with levels of HIV RNA in CD4+ T cells (p<0.02) and with the quantity and binding avidity of circulating anti-HIV antibodies (p<0.009), suggesting a role of galectin-9 in regulating HIV transcription and viral production in vivo during therapy. Our data suggest that galectin-9 and the host glycosylation machinery should be explored as foundations for novel HIV cure strategies

Weak-coupling expansions for the attractive Holstein and Hubbard models

Weak-coupling expansions (conserving approximations) are carried out for the attractive Holstein and Hubbard models (on an infinite-dimensional hypercubic lattice) that include all bandstructure and vertex correction effects. Quantum fluctuations are found to renormalize transition temperatures by factors of order unity, but may be incorporated into the superconducting channel of Migdal-Eliashberg theory by renormalizing the phonon frequency and the interaction strength.Comment: 10 pages, (five figures available from the author by request) typeset with ReVTeX, preprint NSF-ITP-93-10