Formal Identification of Right-Grained Services for Service-Oriented Modeling

Abstract. Identifying the right-grained services is important to lead the successful service orientation because it has a direct impact on two major goals: the composability of loosely-coupled services, and the reusability of individual services in different contexts. Although the concept of service orientation has been intensively debated in recent years, a unified methodic approach for identifying services has not yet been reached. In this paper, we suggest a formal approach to identify services at the right level of granularity from the business process model. Our approach uses the concept of graph clustering and provides a systematical approach by defining the cost metric as a measure of the interaction costs. To effectively extract service information from the business model, we take activities as the smallest units in service identification and cluster activities with high interaction cost into a task through hierarchical clustering algorithm, so as to reduce the coupling of remote tasks and to increase local task cohesion

Acute urticarial rash after covid-19 vaccination containing polysorbate 80

We present the case of a 48-year-old Caucasian woman, who developed an acute urticarial rash after the second dose of coronavirus disease 2019 (COVID-19) vaccination with Oxford-AstraZeneca. Though the most common cutaneous adverse reactions to vaccines are non-al-lergic, we believe the rash may represent an immediate hypersensitivity type I reaction against the vaccine excipient Polysorbate 80 (Pol80), configuring an acute allergic urticaria. Skin prick test with Pol80, were performed and resulted positive, confirming the role of Pol80 in eliciting immediate hypersensitivity in our patient. Of note, sensitizing excipients contained in COVID-19 vaccines are commonly used in everyday products and preexisting sensitizations may cause allergic reactions to vaccines, highlighting the need to undergo allergy consultation upon vaccine administration