The Role of Canids in Ritual and Domestic Contexts: New Ancient DNA Insights from Complex Hunter-Gatherer Sites in Prehistoric Central California

This study explores the interrelationship between the genus Canis and hunter–gatherers through a case study of prehistoric Native Americans in the San Francisco Bay-Sacramento Delta area. A distinctive aspect of the region\u27s prehistoric record is the interment of canids, variously classified as coyotes, dogs, and wolves. Since these species are difficult to distinguish based solely on morphology, ancient DNA analysis was employed to distinguish species. The DNA study results, the first on canids from archaeological sites in California, are entirely represented by domesticated dogs (including both interments and disarticulated samples from midden deposits). These results, buttressed by stable isotope analyses, provide new insight into the complex interrelationship between humans and canids in both ritual and prosaic contexts, and reveal a more prominent role for dogs than previously envisioned

Effect of statins on venous thromboembolic events: a meta-analysis of published and unpublished evidence from randomised controlled trials

Background - It has been suggested that statins substantially reduce the risk of venous thromboembolic events. We sought to test this hypothesis by performing a meta-analysis of both published and unpublished results from randomised trials of statins. Methods and Findings - We searched MEDLINE, EMBASE, and Cochrane CENTRAL up to March 2012 for randomised controlled trials comparing statin with no statin, or comparing high dose versus standard dose statin, with 100 or more randomised participants and at least 6 months' follow-up. Investigators were contacted for unpublished information about venous thromboembolic events during follow-up. Twenty-two trials of statin versus control (105,759 participants) and seven trials of an intensive versus a standard dose statin regimen (40,594 participants) were included. In trials of statin versus control, allocation to statin therapy did not significantly reduce the risk of venous thromboembolic events (465 [0.9%] statin versus 521 [1.0%] control, odds ratio [OR] = 0.89, 95% CI 0.78–1.01, p = 0.08) with no evidence of heterogeneity between effects on deep vein thrombosis (266 versus 311, OR 0.85, 95% CI 0.72–1.01) and effects on pulmonary embolism (205 versus 222, OR 0.92, 95% CI 0.76–1.12). Exclusion of the trial result that provided the motivation for our meta-analysis (JUPITER) had little impact on the findings for venous thromboembolic events (431 [0.9%] versus 461 [1.0%], OR = 0.93 [95% CI 0.82–1.07], p = 0.32 among the other 21 trials). There was no evidence that higher dose statin therapy reduced the risk of venous thromboembolic events compared with standard dose statin therapy (198 [1.0%] versus 202 [1.0%], OR = 0.98, 95% CI 0.80–1.20, p = 0.87). Risk of bias overall was small but a certain degree of effect underestimation due to random error cannot be ruled out. Please see later in the article for the Editors' Summary. Conclusions - The findings from this meta-analysis do not support the previous suggestion of a large protective effect of statins (or higher dose statins) on venous thromboembolic events. However, a more moderate reduction in risk up to about one-fifth cannot be ruled out

Solar Oscillations and Convection: II. Excitation of Radial Oscillations

Solar p-mode oscillations are excited by the work of stochastic, non-adiabatic, pressure fluctuations on the compressive modes. We evaluate the expression for the radial mode excitation rate derived by Nordlund and Stein (Paper I) using numerical simulations of near surface solar convection. We first apply this expression to the three radial modes of the simulation and obtain good agreement between the predicted excitation rate and the actual mode damping rates as determined from their energies and the widths of their resolved spectral profiles. We then apply this expression for the mode excitation rate to the solar modes and obtain excellent agreement with the low l damping rates determined from GOLF data. Excitation occurs close to the surface, mainly in the intergranular lanes and near the boundaries of granules (where turbulence and radiative cooling are large). The non-adiabatic pressure fluctuations near the surface are produced by small instantaneous local imbalances between the divergence of the radiative and convective fluxes near the solar surface. Below the surface, the non-adiabatic pressure fluctuations are produced primarily by turbulent pressure fluctuations (Reynolds stresses). The frequency dependence of the mode excitation is due to effects of the mode structure and the pressure fluctuation spectrum. Excitation is small at low frequencies due to mode properties -- the mode compression decreases and the mode mass increases at low frequency. Excitation is small at high frequencies due to the pressure fluctuation spectrum -- pressure fluctuations become small at high frequencies because they are due to convection which is a long time scale phenomena compared to the dominant p-mode periods.Comment: Accepted for publication in ApJ (scheduled for Dec 10, 2000 issue). 17 pages, 27 figures, some with reduced resolution -- high resolution versions available at http://www.astro.ku.dk/~aake/astro-ph/0008048

The McGill score as a screening test for obstructive sleep disordered breathing in children with co-morbidities

Background: The McGill score is used to stratify severity of oximetry in children referred for investigation of obstructive sleep apnoea (OSA) to identify those with more severe disease and prioritize treatment. We hypothesized that its Positive predictive value (PPV) and Negative predictive value (NPV) in detecting OSA differs significantly between children with medical conditions and otherwise healthy children. / Methods: We performed a two-year retrospective analysis of children referred for investigation of OSA who underwent a cardiorespiratory (CR) polygraphy study. McGill score was calculated from the oximetry trace blinded to polygraphy results. We looked at 2 definitions of OSA: Obstructive Apnoea Hypopnoea Index (oAHI) ≥1 and ≥5. McGill sensitivity, specificity, PPV and NPV were calculated. McGill score=1 was considered normal or inconclusive, >1 abnormal. / Results: We studied 312 children, 190 males (61%), median age 4.5 (2.4-7.9) years. 129 were otherwise healthy and 183 had associated medical conditions. The PPV of the McGill score was significantly lower in children with medical conditions than otherwise healthy children. The NPV was similar in both groups of children. / Conclusions: The higher number of false positives in children with medical conditions may be due to non-obstructive causes such as central apnoeas. Children with underlying lung disease are also more likely to desaturate following a brief apnoea or hypopnoea. Children with co-morbidities who have an abnormal McGill score should not be assumed to have OSA and need more detailed sleep studies to determine the reason for the oxygen desaturations

Modification to the Luminosity Distance Redshift Relation in Modified Gravity Theories

We derive an expression for the luminosity distance as a function of redshift for a flat Robertson-Walker spacetime perturbed by arbitrary scalar perturbations possibly produced by a modified gravity theory with two different scalar perturbation potentials. Measurements of the luminosity distance as function of redshift provide a constraint on a combination of the scalar potentials and so they can complement weak lensing and other measurements in trying to distinguish among the various alternative theories of gravity.Comment: 15 pages, we discuss in more detail how the luminosity distance expression can be used to differentiate among various theories of gravit

NEAR-SURFACE EFFECTS IN MODELLING OSCILLATIONS OF ETA BOO

Following the report of solar-like oscillations in the G0 V star eta Boo (Kjeldsen et al. 1995, AJ 109, 1313), a first attempt to model the observed frequencies was made by Christensen-Dalsgaard et al. (1995, ApJ Letters, in press). This attempt succeeded in reproducing the observed frequency separations, although there remained a difference of about 10 microHz between observed and computed frequencies. In those models, the near-surface region of the star was treated rather crudely. Here we consider more sophisticated models that include non-local mixing-length theory, turbulent pressure and nonadiabatic oscillations.Comment: uuencoded and compressed Postscript (2 pages, including figure); To appear in Proceedings of IAU Colloquium 155, "Astrophysical Applications of Stellar Pulsation", Cape Town, South Afric

Space and Ground Based Pulsation Data of Eta Bootis Explained with Stellar Models Including Turbulence

The space telescope MOST is now providing us with extremely accurate low frequency p-mode oscillation data for the star Eta Boo. We demonstrate in this paper that these data, when combined with ground based measurements of the high frequency p-mode spectrum, can be reproduced with stellar models that include the effects of turbulence in their outer layers. Without turbulence, the l=0 modes of our models deviate from either the ground based or the space data by about 1.5-4.0 micro Hz. This discrepancy can be completely removed by including turbulence in the models and we can exactly match 12 out of 13 MOST frequencies that we identified as l=0 modes in addition to 13 out of 21 ground based frequencies within their observational 2 sigma tolerances. The better agreement between model frequencies and observed ones depends for the most part on the turbulent kinetic energy which was taken from a 3D convection simulation for the Sun.Comment: 13 pages, 7 figures, ApJ in pres