Breathers on quantized superfluid vortices

We consider the propagation of breathers along a quantized superfluid vortex. Using the correspondence between the local induction approximation (LIA) and the nonlinear Schrödinger equation, we identify a set of initial conditions corresponding to breather solutions of vortex motion governed by the LIA. These initial conditions, which give rise to a long-wavelength modulational instability, result in the emergence of large amplitude perturbations that are localized in both space and time. The emergent structures on the vortex filament are analogous to loop solitons but arise from the dual action of bending and twisting of the vortex. Although the breather solutions we study are exact solutions of the LIA equations, we demonstrate through full numerical simulations that their key emergent attributes carry over to vortex dynamics governed by the Biot-Savart law and to quantized vortices described by the Gross-Pitaevskii equation. The breather excitations can lead to self-reconnections, a mechanism that can play an important role within the crossover range of scales in superfluid turbulence. Moreover, the observation of breather solutions on vortices in a field model suggests that these solutions are expected to arise in a wide range of other physical contexts from classical vortices to cosmological strings

Parallelizing Navier-Stokes Computations on a Variety of Architectural Platforms

We study the computational, communication, and scalability characteristics of a Computational Fluid Dynamics application, which solves the time accurate flow field of a jet using the compressible Navier-Stokes equations, on a variety of parallel architectural platforms. The platforms chosen for this study are a cluster of workstations (the LACE experimental testbed at NASA Lewis), a shared memory multiprocessor (the Cray YMP), distributed memory multiprocessors with different topologies-the IBM SP and the Cray T3D. We investigate the impact of various networks, connecting the cluster of workstations, on the performance of the application and the overheads induced by popular message passing libraries used for parallelization. The work also highlights the importance of matching the memory bandwidth to the processor speed for good single processor performance. By studying the performance of an application on a variety of architectures, we are able to point out the strengths and weaknesses of each of the example computing platforms

Transcriptomic Analysis of Age-Associated Periventricular Lesions Reveals Dysregulation of the Immune Response.

White matter lesions (WML) are a common feature of the ageing brain associated with cognitive impairment. The gene expression profiles of periventricular lesions (PVL, n = 7) and radiologically-normal-appearing (control) periventricular white matter cases (n = 11) obtained from the Cognitive Function and Ageing Study (CFAS) neuropathology cohort were interrogated using microarray analysis and NanoString to identify novel mechanisms potentially underlying their formation. Histological characterisation of control white matter cases identified a subgroup (n = 4) which contained high levels of MHC-II immunoreactive microglia, and were classified as "pre-lesional." Microarray analysis identified 2256 significantly differentially-expressed genes (p ≤ 0.05, FC ≥ 1.2) in PVL compared to non-lesional control white matter (1378 upregulated and 878 downregulated); 2649 significantly differentially-expressed genes in "pre-lesional" cases compared to PVL (1390 upregulated and 1259 downregulated); and 2398 significantly differentially-expressed genes in "pre-lesional" versus non-lesional control cases (1527 upregulated and 871 downregulated). Whilst histological evaluation of a single marker (MHC-II) implicates immune-activated microglia in lesion pathology, transcriptomic analysis indicates significant downregulation of a number of activated microglial markers and suggests established PVL are part of a continuous spectrum of white matter injury. The gene expression profile of "pre-lesional" periventricular white matter suggests upregulation of several signalling pathways may be a neuroprotective response to prevent the pathogenesis of PVL

Scattering of Line-Ring Vortices in a Superfluid

We study the scattering of vortex rings by a superfluid line vortex using the Gross-Pitaevskii equation in a parameter regime where a hydrodynamic description based on a vortex filament approximation is applicable. By using a vortex extraction algorithm, we are able to track the location of the vortex ring as a function of time. Using this, we show that the scattering of the vortex ring in our Gross-Pitaevskii simulations is well captured by the local induction approximation of a vortex filament model for a wide range of impact parameters. The scattering of a vortex ring by a line vortex is characterised by the initial offset of the centre of the ring from the axis of the vortex. We find that a strong asymmetry exists in the scattering of a ring as a function of this initial scattering parameter

Evaluation of the physical, chemical, bacteriological and trace metals concentrations in different brands of packaged drinking water

—Human survival largely depends on potable water quality. This study used current analytical procedures and compared with the National Agency for Food and Drug Administration Control (NAFDAC) drinking water specification to evaluate the physio-chemical and microbiological characteristics of fifteen packaged water brands that are available locally. Atomic absorption spectroscopy was used to determine trace metals while instrumental techniques determined the physical and chemical parameters. The evaluation focused on the pH, colour, total dissolved solids, turbidity, dissolved oxygen, fluoride, chloride, iron, zinc, magnesium, calcium, potassium, and sodium. In all the samples examined, chromium, manganese, cadmium, and copper were not detected. However, total bacterial counts were discovered in samples (S1, S2, S3, B1 and B2) with values of 2, 3, 5, 3 and 1 cfu/100 ml, respectively. Packaged water containing these type and quantity of bacteria are not fit for consumption by human beings. It requires the most appropriate techniques for processing

EVER Proteins, Key Elements of the Natural Anti-Human Papillomavirus Barrier, Are Regulated upon T-Cell Activation

Human papillomaviruses (HPV) cause a variety of mucosal and skin lesions ranging from benign proliferations to invasive carcinomas. The clinical manifestations of infection are determined by host-related factors that define the natural anti-HPV barrier. Key elements of this barrier are the EVER1 and EVER2 proteins, as deficiency in either one of the EVER proteins leads to Epidermodysplasia Verruciformis (EV), a genodermatosis associated with HPV-induced skin carcinoma. Although EVERs have been shown to regulate zinc homeostasis in keratinocytes, their expression and function in other cell types that may participate to the anti-HPV barrier remain to be investigated. In this work, we demonstrate that EVER genes are expressed in different tissues, and most notably in lymphocytes. Interestingly, in contrast to the skin, where EVER2 transcripts are hardly detectable, EVER genes are both abundantly expressed in murine and human T cells. Activation of CD4+ and CD8+ T cells via the TCR triggers a rapid and profound decrease in EVER expression, accompanied by an accumulation of free Zn2+ ions. Thus, EVER proteins may be involved in the regulation of cellular zinc homeostasis in lymphocytes. Consistent with this hypothesis, we show that the concentration of Zn2+ ions is elevated in lymphoblastoid cells or primary T cells from EVER2-deficient patients. Interestingly, we also show that Zn2+ excess blocks T-cell activation and proliferation. Therefore, EVER proteins appear as key components of the activation-dependent regulation of Zn2+ concentration in T cells. However, the impact of EVER-deficiency in T cells on EV pathogenesis remains to be elucidated

An experimental study of cathodic protection for chloride contaminated reinforced concrete

Cathodic protection (CP) is being increasingly used on reinforced concrete structures to protect steel reinforcing bars from corrosion in aggressive conditions. Due to the complexity of environmental conditions, the design specifications in national and international standards are still open to discussion to achieve both sufficient and efficient protection for reinforced concrete structures in engineering practices. This paper reports an experimental research to investigate the influence of chloride content on concrete resistivity, rebar corrosion rate and the performance of CP operation using different current densities. It aims to understand the correlation between the chloride content and concrete resistivity together with the CP current requirement, and to investigate the precision of the CP design criteria in standards

Structural Properties of Thermoluminescence Dosimeter Materials, Preparation, Application, and Adaptability: A Systematic Review

Thermoluminescence dosimeters (TLDs) are widely used in radiation dosimetry due to their excellent properties, such as high sensitivity, small size, and ability to measure low doses of radiation. This review focuses on the structural properties of TLD materials, as well as their preparation, application, and adaptability. The review covers the various types of TLD materials, crystal structure, and properties, including energy response and fading characteristics. The different methods used to prepare TLD materials, such as solid-state synthesis, sol-gel synthesis, and solution growth methods, are discussed in detail. The review also includes a detailed discussion of the various applications of TLDs, including medical, environmental, and industrial radiation dosimetry. Extensive information on TLD is reviewed, and the TL characteristics that have a noticeable impact on the TL dosimetry potential for human and other purpose utilisation, such as mineral, oil, and gas resource investigation, can be done using natural and artificial TL signals. Information on TL measurement process requirements and the TL characteristics that have a noticeable impact on a compound TL dosimetry potential are also addressed. Finally, the review concludes by highlighting the adaptability of TLD materials to different dosimetry applications and their potential use in the future

Dendrimers as anti-inflammatory agents

Dendrimers constitute an intriguing class of macromolecules which find applications in a variety of areas including biology. These hyperbranched macromolecules with tailored backbone and surface groups have been extensively investigated as nanocarriers for gene and drug delivery, by molecular encapsulation or covalent conjugation. Dendrimers have provided an excellent platform to develop multivalent and multifunctional nanoconjugates incorporating a variety of functional groups including drugs which are known to be anti-inflammatory agents. Recently, dendrimers have been shown to possess anti-inflammatory properties themselves. This unexpected and intriguing discovery has provided an additional impetus in designing novel active pharmaceutical agents. In this review, we highlight some of the recent developments in the field of dendrimers as nanoscale anti-inflammatory agents