3,421 research outputs found

    Epitaxial growth and transport properties of Nb-doped SrTiO3_{3} thin films

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    Nb-doped SrTiO3_{3} epitaxial thin films have been prepared on (001) SrTiO3_{3} substrates using pulsed laser deposition. A high substrate temperature (>1000∘C>1000^{\circ}{C}) was found to be necessary to achieve 2-dimensional growth. Atomic force microscopy reveals atomically flat surfaces with 3.9 \AA steps. The films show a metallic behavior, residual resistivity ratios between 10 and 100, and low residual resistivity of the order of 10−4^{-4}Ω\Omegacm. At 0.3 K, a sharp superconducting transition, reaching zero resistance, is observed.Comment: 4 pages, 4 figure

    Comparison of Bond Character in Hydrocarbons and Fullerenes

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    We present a comparison of the bond polarizabilities for carbon-carbon bonds in hydrocarbons and fullerenes, using two different models for the fullerene Raman spectrum and the results of Raman measurements on ethane and ethylene. We find that the polarizabilities for single bonds in fullerenes and hydrocarbons compare well, while the double bonds in fullerenes have greater polarizability than in ethylene.Comment: 7 pages, no figures, uses RevTeX. (To appear in Phys. Rev. B.

    The first year of Antarctic VLBI observations

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    We are undertaking a series of geodetic VLBI observations between the Syowa Station 11-m antenna in Antarctica, and the 26-m antennas in Hobart Tasmania and Hartebeesthoek South Africa. These observations are the beginning of our campaign to monitor the motion and stability of the Antarctic plate. We describe here the results of the first year\u27s observations made during the southern summer and winter of 1998. Two mutually incompatible recording systems, K4 and S2, are used. The Mitaka FX Correlator was used to correlate these data. By using software called CALC3/MSOLV, the mean position of the antenna\u27s geodetic reference point was found to be X=1766194.152±0.006m, Y=1460410.923±0.005m and Z=- 5932273.329±0.015m at the epoch of 1998.9 in the International Terrestrial Reference Frame 2000 (ITRF2000) system. From a comparison with measurements made with other space geodetic techniques we estimate that our results have typical uncertainties of no more than 2 to 3cm in each coordinate

    COVID-19 and vertical transmission: assessing the expression of ACE2 / TMPRSS2 in the human fetus and placenta to assess the risk of SARS-CoV-2 infection

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    Background: While pregnant women have been identified as a potentially at-risk group concerning COVID-19 infection, little is known regarding the susceptibility of the fetus to infection. Co-expression of ACE2 and TMPRSS2 has been identified as a pre-requisite for infection, and expression across different tissues is known to vary between children and adults. However, the expression of these proteins in the fetus is unknown. Methods: We performed a retrospective analysis of single cell data repositories. This data was then validated at both gene and protein level by performing qRT-PCR and two-colour immunohistochemistry on a library of second-trimester human fetal tissues. Findings: TMPRSS2 is present at both gene and protein level in the predominantly epithelial fetal tissues analysed. ACE2 is present at significant levels, only in the fetal intestine and kidney and is not expressed in the fetal lung. The placenta is also negative for the two proteins both during development and at term. Interpretation: This dataset indicates that the lungs are unlikely to be a viable route of SARS-CoV2 fetal infection. The fetal kidney, despite presenting both the proteins required for the infection, is anatomically protected from the exposure to the virus. However, the GI tract is likely to be susceptible to infection due to its high co-expression of both proteins, as well as its exposure to potentially infected amniotic fluid

    Internal states of model isotropic granular packings. III. Elastic properties

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    In this third and final paper of a series, elastic properties of numerically simulated isotropic packings of spherical beads assembled by different procedures and subjected to a varying confining pressure P are investigated. In addition P, which determines the stiffness of contacts by Hertz's law, elastic moduli are chiefly sensitive to the coordination number, the possible values of which are not necessarily correlated with the density. Comparisons of numerical and experimental results for glass beads in the 10kPa-10MPa range reveal similar differences between dry samples compacted by vibrations and lubricated packings. The greater stiffness of the latter, in spite of their lower density, can hence be attributed to a larger coordination number. Voigt and Reuss bounds bracket bulk modulus B accurately, but simple estimation schemes fail for shear modulus G, especially in poorly coordinated configurations under low P. Tenuous, fragile networks respond differently to changes in load direction, as compared to load intensity. The shear modulus, in poorly coordinated packings, tends to vary proportionally to the degree of force indeterminacy per unit volume. The elastic range extends to small strain intervals, in agreement with experimental observations. The origins of nonelastic response are discussed. We conclude that elastic moduli provide access to mechanically important information about coordination numbers, which escape direct measurement techniques, and indicate further perspectives.Comment: Published in Physical Review E 25 page

    Tuning of metal-insulator transition of two-dimensional electrons at parylene/SrTiO3_3 interface by electric field

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    Electrostatic carrier doping using a field-effect-transistor structure is an intriguing approach to explore electronic phases by critical control of carrier concentration. We demonstrate the reversible control of the insulator-metal transition (IMT) in a two dimensional (2D) electron gas at the interface of insulating SrTiO3_3 single crystals. Superconductivity was observed in a limited number of devices doped far beyond the IMT, which may imply the presence of 2D metal-superconductor transition. This realization of a two-dimensional metallic state on the most widely-used perovskite oxide is the best manifestation of the potential of oxide electronics

    Signaling via interleukin-4, receptor alpha chain is required for successful vaccination against schistosomiasis in BALB/c mice

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    Radiation-attenuated (RA) schistosome larvae are potent stimulators of innate immune responses at the skin site of exposure (pinna) that are likely to be important factors in the development of Th1-mediated protective immunity. In addition to causing an influx of neutrophils, macrophages, and dendritic cells (DCs) into the dermis, RA larvae induced a cascade of chemokine and cytokine secretion following in vitro culture of pinna biopsy samples. While macrophage inflammatory protein 1 and interleukin-1 (IL-1) were produced transiently within the first few days, the Th1-promoting cytokines IL-12 and IL-18 were secreted at high levels until at least day 14. Assay of C3H/HeJ mice confirmed that IL-12 secretion was not due to lipopolysaccharide contaminants binding Toll-like receptor 4. Significantly, IL-12 p40 secretion was sustained in pinnae from vaccinated mice but not in those from nonprotected infected mice. In contrast, IL-10 was produced from both vaccinated and infected mice. This cytokine regulates IL-12-associated dermal inflammation, since in vaccinated IL-10/ mice, pinna thickness was greatly increased concurrent with elevated levels of IL-12 p40. A significant number of IL-12 p40 cells were detected as emigrants from in vitro-cultured pinnae, and most were within a population of rare large granular cells that were Ia, consistent with their being antigen-presenting cells. Labeling of IL-12 cells for CD11c, CD205, CD8, CD11b, and F4/80 indicated that the majority were myeloid DCs, although a proportion were CD11c F4/80, suggesting that macrophages were an additional source of IL-12 in the skin

    Anti-inflammatory effect of glucose—mannose binding lectins isolated from Brazilian beans

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    Selectins are essential for leukocyte recruitment in inflammation. Because of a lectin domain present in the selectin structure, we investigated the anti-inflammtory activity of six mannose–glucose binding lectins from brazilian beans: Dioclea guianensis-DguiL; D. grandiflora-DgL; Cratylia floribunda-CfL; D. violacea-D.vL; D. virgata-DvirL and Canavalia brasiliensis-ConBr. The lectins were injected intravenously (i.v.) into rats (0.1 and 1.0 mg/kg; 30 min before irritants) and its activities compared to E. coli endotoxin (LPS,30 μg/kg i.v.). Three lectins (DvL, CfL and DguiL), although less intense than LPS, inhibited the neutrophil migration induced by carrageenan (Cg, 300 μg) in a dose-dependent manner (0.1 and 1.0 mg/kg). DvL activity was reversed by 0.1 M α-D-methyl-mannoside (α-CH3), but not by 0.1 M α-D-galactose. The fMLP (44 ng)-induced neutrophil migration was also reduced by these lectins. Endotoxin contamination of lectin samples could be excluded since α-CH3 treatment reversed the DvL effect, but did not modify LPS inhibitory activity. Carrageenan (300 μg)-induced paw oedema was also reduced by LPS or lectin treatments. Conversely, none of the tested lectins inhibited dextran (Dex, 300 μg)-induced paw oedema, a classical leukocyte independent model, or zymosan (Zy, 1.0 mg)-induced peritonitis and paw oedema. LPS showed no effect upon Dex-induced paw oedema and barely reduced (25%) the oedematogenic effects of zymosan. As proposed for LPS, the lectin inhibitory activity was better observed on neutrophil-mediated inflammatory reactions. We speculate that the plant lectin antiinflammatory activity is probably due to a competitive blockage of a common leukocyte and/or endothelial selectin carbohydrate ligand

    The spectral energy distribution of the redshift 7.1 quasar ULAS J1120+0641

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    We present new observations of the highest-redshift quasar known, ULAS J1120+0641, redshift z=7.084z=7.084, obtained in the optical, at near-, mid-, and far-infrared wavelengths, and in the sub-mm. We combine these results with published X-ray and radio observations to create the multiwavelength spectral energy distribution (SED), with the goals of measuring the bolometric luminosity LbolL_{\rm bol}, and quantifying the respective contributions from the AGN and star formation. We find three components are needed to fit the data over the wavelength range 0.12−1000 μ0.12-1000\,\mum: the unobscured quasar accretion disk and broad-line region, a dusty clumpy AGN torus, and a cool 47K modified black body to characterise star formation. Despite the low signal-to-noise ratio of the new long-wavelength data, the normalisation of any dusty torus model is constrained within ±40%\pm40\%. We measure a bolometric luminosity Lbol=2.6±0.6×1047 L_{\rm bol}=2.6\pm0.6\times10^{47}\,erg \,s−1=6.7±1.6×1013L⊙^{-1}=6.7 \pm 1.6\times10^{13}L_{\odot}, to which the three components contribute 31%,32%,3%31\%,32\%,3\%, respectively, with the remainder provided by the extreme UV <0.12 μ<0.12\,\mum. We tabulate the best-fit model SED. We use local scaling relations to estimate a star formation rate (SFR) in the range 60−270 M⊙60-270\,{\rm M}_\odot/yr from the [C II\,{\scriptsize \rm II}] line luminosity and the 158 μ158\,\mum continuum luminosity. An analysis of the equivalent widths of the [C II\,{\scriptsize \rm II}] line in a sample of z>5.7z>5.7 quasars suggests that these indicators are promising tools for estimating the SFR in high-redshift quasars in general. At the time observed the black hole was growing in mass more than 100 times faster than the stellar bulge, relative to the mass ratio measured in the local universe, i.e. compared to MBH/Mbulge≃1.4×10−3{M_{\rm BH}}/{M_{\rm bulge}} \simeq 1.4\times10^{-3}, for ULAS J1120+0641 we measure M˙BH/M˙bulge≃0.2{\dot{M}_{\rm BH}}/{\dot{M}_{\rm bulge}} \simeq 0.2.Comment: Accepted for publication in A&A. 10 pages, 5 figures, 5 table
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