Perceptual Learning of Fine Contrast Discrimination Under Non-roving, Roving-Without-Flanker, and Roving-with-Flanker Conditions and its Relation to Neuronal Activity in Macaque V1

\ua9 The Author(s) 2024.Perceptual learning refers to an improvement in perceptual abilities with training. Neural signatures of visual perceptual learning have been demonstrated mostly in mid- and high-level cortical areas, while changes in early sensory cortex were often more limited. We recorded continuously from multiple neuronal clusters in area V1 while macaque monkeys learned a fine contrast categorization task. Monkeys performed the contrast discrimination task initially when a constant-contrast sample stimulus was followed by a test stimulus of variable contrast, whereby they had to indicate whether the test was of lower or higher contrast than the sample. This was followed by sessions where we employed stimulus roving; i.e. the contrast of the sample stimulus varied from trial to trial. Finally, we trained animals, under ‘stimulus roving-with-flanker’ conditions, where the test stimuli to be discriminated were flanked by ‘flanking stimuli’. Perceptual discrimination abilities improved under non-roving conditions and under roving-with-flanker conditions as training progressed. Neuronal discrimination abilities improved with training mostly under non-roving conditions, but the effect was modest and limited to the most difficult contrast. Choice probabilities, quantifying how well neural activity is correlated with choice, equally increased with training during non-roving, but not during either of the roving conditions (with and without flankers). Noise correlations changed with training in both monkeys, but the changes were not consistent between monkeys. In one monkey, noise correlations decreased with training for non-roving and both roving conditions. In the other monkey, noise correlations changed for some conditions, but lacked a systematic pattern. Thus, while perceptual learning occurred under non-roving and roving-with-flanker conditions, the changes in neural activity in V1 were overall modest and were essentially absent under the different roving conditions

Traveling Granular Segregation Patterns in a Long Drum Mixer

Mixtures of granular media often exhibit size segregation along the axis of a partially-filled, horizontal, rotating cylinder. Previous experiments have observed axial bands of segregation that grow from concentration fluctuations and merge in a manner analogous to spinodal decomposition. We have observed that a new dynamical state precedes this effect in certain mixtures: bi-directional traveling waves. By preparing initial conditions, we found that the wave speed decreased with wavelength. Such waves appear to be inconsistent with simple PDE models which are first order in time.Comment: 11 page

Evidence of Compton cooling during an X-ray flare supports a neutron star nature of the compact object in 4U1700-37

Based on new Chandra X-ray telescope data, we present empirical evidence of plasma Compton cooling during a flare in the non pulsating massive X-ray binary 4U1700-37. This behaviour might be explained by quasispherical accretion onto a slowly rotating magnetised neutron star. In quiescence, the neutron star in 4U1700-37 is surrounded by a hot radiatively cooling shell. Its presence is supported by the detection of mHz quasi periodic oscillations likely produced by its convection cells. The high plasma temperature and the relatively low X-ray luminosity observed during the quiescence, point to a small emitting area about 1 km, compatible with a hot spot on a NS surface. The sudden transition from a radiative to a significantly more efficient Compton cooling regime triggers an episode of enhanced accretion resulting in a flare. During the flare, the plasma temperature drops quickly. The predicted luminosity for such transitions, Lx = 3 x 10^35 erg s-1, is very close to the luminosity of 4U1700-37 during quiescence. The transition may be caused by the accretion of a clump in the stellar wind of the donor star. Thus, a magnetised NS nature of the compact object is strongly favoured.Comment: Accepted for publication in MNRA

High-resolution X-ray spectroscopy of supergiant HMXB 4U 1700−37 during the compact object eclipse

We present an analysis of the first observation of the iconic high-mass X-ray binary 4U 1700−37 with the Chandra High-Energy Transmission Gratings (HETGs) during an X-ray eclipse. The goal of the observation was to study the structure/physical conditions in the clumpy stellar wind through high-resolution spectroscopy. We find the following: (a) Emission-line brightness from K-shell transitions, corresponding to near-neutral species, directly correlates with continuum illumination. However, these lines do not greatly diminish during eclipse. This is readily explained if fluorescence K α emission comes from the bulk of the wind. (b) The highly ionized Fe xxv and Fe xxvi Ly α diminish during eclipse. Thus, they must be produced in the vicinity of the compact object where log ξ > 3. (c) To describe the emission-line spectrum, the sum of two self-consistent photoionization models with low ionization (log ξ ∼ −1) and high ionization (log ξ ∼ 2.4) is required. From their emission measures, the clump-to-interclump density ratio can be estimated to be nc/ni ∼ 300. To fit the complex He-like Si xiii profile, the plasma requires a broadening with vbulk ∼ 840 km s−1. Reproducing the observed r ≈ f line fluxes requires the addition of a third collisionally ionized plasma. (d) Emission-line widths appear unresolved at the HETG resolution with the exception of silicon. There is no clear radial segregation between (quasi-)neutral and ionized species, consistent with cold wind clumps interspersed in a hot rarefied interclump medium.This research has been funded under the project ESP2017-85691-P. The research leading to these results has received funding from the European Union’s Horizon 2020 Programme under the Activities for the High-Energy Astrophysiscs Domain (AHEAD) project (grant agreement no. 654215). Victoria Grinberg (VG) was supported through the Margarete von Wrangell fellowship by the ESF and the Ministry of Science, Research and the Arts of Baden-Württemberg. Work at LLNL was performed under the auspices of the U.S. Department of Energy under contract no. DE-AC52-07NA27344 and supported through National Aeronautics and Space Administration (NASA) grants to Lawrence Livermore National Laboratory (LLNL). Lida M. Oskinova acknowledges Deutsches Zentrum für Luft und Raumfahrt (DLR) grant FKZ 50 OR 1508 and partial support by the Russian Government Program of Competitive Growth of Kazan Federal University

Physical performance and quality of life in older adults: Is there any association between them and potential drug interactions in Polymedicated Octogenarians?

Producción CientíficaOlder adults are at increased risk of several cytochrome P450 (CYP) drug interactions that can result in drug toxicity, reduced pharmacological effect, and adverse drug reactions. This study aimed to assess the prevalence of potential CYP interactions referring to the most clinically relevant drugs and exploring the relationship between them and quality of life and physical performance in Spanish octogenarians. Institutionalized and community-dwelling octogenarians (n = 102) treated at three primary care centers, were recruited by a research nurse. Anthropometric measurements, chronic diseases, prescribed drugs, quality of life, physical performance, mobility skills, hand grip strength and cognitive status data were collected. Potential CYP drug-drug interactions (DDIs) were selected referring to the main CYP implicated in their metabolism. The 72.2% of recruited octogenarians presented potentially inappropriate CYP inhibitor-substrate or CYP inductor-substrate combinations. Analyzing the EuroQol Visual Analogue scale (EQ-VAS) results, patients with a potential CYP DDI perceived worse health status than patients without it (p = 0.004). In addition, patients with a potential CYP DDI presented worse exercise capacity, kinesthetic abilities, or mobility than those who didn’t present a potential interaction (p = 0.01, p = 0.047, and p = 0.02, respectively). To investigate and control factors associated with loss of muscle strength and poor quality of life, polypharmacy and DDIs could help institutions in the management of physical frailty.Fundación Científica Caja Rural de Soria (project 00200200227

King-Type Derivative-Free Iterative Families: Real and Memory Dynamics

A biparametric family of derivative-free optimal iterative methods of order four, for solving nonlinear equations, is presented. From the error equation of this class, different families of iterative schemes with memory can be designed increasing the order of convergence up to six. The real stability analysis of the biparametric family without memory is made on quadratic polynomials, finding areas in the parametric plane with good performance. Moreover, in order to study the real behavior of the parametric class with memory, we associate it with a discrete multidimensional dynamical system. By analyzing the fixed and critical points of its vectorial rational function, we can select those methods with best stability properties

Implications of zoonotic and vector-borne parasites to free-roaming cats in central Spain

Cats are definitive hosts and reservoirs for several parasites, some of which are responsible for serious zoonotic diseases. We conducted a case-control study of data from a trap-neuter-return (TNR) programme (years 2014-2017) designed to examine the prevalence of zoonotic parasites in free-roaming cats living in urban areas of central Spain. In the animal population tested (n = 263), we detected a 29.2% prevalence of endoparasites, including high rates of cestodes (12.9%) and Toxocara cati (11.7%). While faecal samples showed no Toxoplasma gondii oocysts, the seroprevalence of T. gondii infection was 24.2%. Antibodies to Leishmania infantum were detected in 4.8% of the animals, though all skin and blood samples analyzed were PCR negative for this parasite. Ectoparasites (ticks and fleas) were found in 4.6% of the cat population, and 10.6% of the cats were detected with Otodectes cynotis. Finally, 6.3% and 7.9% cats tested positive for feline leukaemia virus and feline immunodeficiency virus, respectively. Our study provides useful information for animal-welfare and public-health, as the parasites detected can affect native wild animals through predation, competition and disease transmission. Our detection of zoonotic parasites such as L. infantum, T. gondii, T. cati, Giardia duodenalis and several ectoparasites prompts an urgent need for health control measures in stray cats.S