“My people seem to be falling to bits”: impotence, memory, and the co-possibility of body and mind in Samuel Beckett’s works

The present thesis examines the representation of the impotent body and mind in a selection of Samuel Beckett’s dramatic and prose works. Aiming to show that the body-mind relation is represented as one of co-implication and co-constitution, this thesis also takes the representation of memory in Beckett’s work as a key site for examining this relation. The thesis seeks to address the centrality of the body and embodied subjectivity in the experience of memory and indeed in signification and experience more generally. In these terms, Chapter 1 analyzes the representation of the figure of the couple in Beckett’s drama of the 1950s – as a metaphor of the body-mind relation – and, in light of Jacques Derrida’s theory of the supplement and Bernard Stiegler’s theory of technics, it discusses how the relationship between physical body and mind is defined by an essential supplementarity that is revealed even (or especially) in their apparent separation. Furthermore, the impotence that marks both elements in Beckett’s writings, when it is seen to lay bare this intrication, can be viewed, in important respects, as enabling rather than merely privative. Chapter 2 discusses the somatic structure of memory as represented in four of Beckett’s later dramatic works composed in the 1970s and 1980s. Similarly to Chapter 1, the second chapter focuses on the more “extreme” representation of bodily impotence in Beckett and demonstrates that rather than a merely “mental” recollection, memory in the work of Beckett is presented as necessarily experienced through, and shaped by, the body itself. In this light, then, it is shown that despite the impotence that marks the body in Beckett’s work of the 1970s and 1980s, the body is a necessary site of memory and retains or discovers a kind of activity in this impotence. Finally, Chapter 3 shifts its attention to Beckett’s prose works in order to explore how such works, reliant on language rather than the physical performance of actors onstage, sustain questions of embodied subjectivity at their heart. Specifically, the chapter argues that, on closer inspection, Beckett’s “literature of the unword” is not an abstention from meaning and its materialization, but one that paradoxically foregrounds that “something” which remains an essential part of it, that is, an embodied subjectivity

The Evidence Behind the Diagnostic Investigation of Canine Idiopathic Epilepsy

<p><strong>Clinical bottom line</strong></p><p>There remains until recently an overall lack of clarity for the practical criteria for the diagnosis of canine idiopathic epilepsy. Signalment and an interictal neurological examination are vital for the diagnosis of idiopathic epilepsy. Despite the current insufficient evidence, the emerge of new diagnostic methods, such as cerebrospinal fluid and/or serum biomarkers, advanced functional neuroimaging techniques and electroencephalography, is likely to change the diagnostic approach in canine epilepsy in the near future.</p

The Evidence Behind the Treatment of Canine Idiopathic Epilepsy

Oral phenobarbital and imepitoin in particular, followed by potassium bromide and levetiracetam are likely to be effective for the treatment of canine idiopathic epilepsy. There is strong evidence supporting the use of oral phenobarbital and imepitoin as ‘first line’ medications. However, there remains a lack of evidence for targeted treatment for the various individual epileptic phenotypes and quite limited evidence on direct comparisons of the efficacy between various anti-epileptic drugs

A reiterative method for calculating the early bactericidal activity of antituberculosis drugs.

Studies of early bactericidal activity (EBA) are important in the rapid evaluation of new antituberculosis drugs. Historically, these have concentrated on the log fall in the viable count in sputum during the first 48 hours of therapy. In this paper, we provide a mathematical model that suggests that the viable count in sputum follows an exponential decay curve with the equation V = S + Me(-kt) (where V is the viable count, M the population of bacteria susceptible to the test drug, S the population susceptible only to sterilizing agents, t the day of sputum collection as related to start of therapy, k the rate constant for the bacteria killed each day, and e the Napierian constant). We demonstrate that data from clinical trials fits the exponential decay model. We propose that future EBA studies should be performed by measuring daily quantitative counts for at least 5 days. We also propose that the comparison of the early bactericidal activity of antituberculosis drugs should be evaluated using the time taken to reduce the viable count by 50% (vt(50)). A further reiterative refinement following a rule set based on statistically the best fit to the exponential decay model is described that will allow investigators to identify anomalous results and thus enhance the accuracy in measuring early bactericidal activity

Approximate inverse systems of uniform spaces and an application of inverse systems

summary:The fundamental properties of approximate inverse systems of uniform spaces are established. The limit space of an approximate inverse sequence of complete metric spaces is the limit of an inverse sequence of some of these spaces. This has an application to the dimension of the limit space of an approximate inverse system. A topologically complete space with $\operatorname{dim} \leq n$ is the limit of an approximate inverse system of metric polyhedra of $\operatorname{dim} \leq n$. A completely metrizable separable space with $\operatorname{dim} \leq n$ is the limit of an inverse sequence of locally finite polyhedra of $\operatorname{dim} \leq n$. Finally, a new proof is derived of the important equality $\operatorname{dim} = \operatorname{Ind}$ for metric spaces

Scalar Love numbers and Love symmetries of 5-dimensional Myers-Perry black hole

The near-zone ``Love'' symmetry resolves the naturalness issue of black hole Love number vanishing with $\text{SL}\left(2,\mathbb{R}\right)$ representation theory. Here, we generalize this proposal to $5$-dimensional asymptotically flat and doubly spinning (Myers-Perry) black holes. We consider the scalar response of Myers-Perry black holes and extract its static scalar Love numbers. In agreement with the naturalness arguments, these Love numbers are, in general, non-zero and exhibit logarithmic running unless certain resonant conditions are met; these conditions include new cases with no previously known analogs. We show that there exist two near-zone truncations of the equations of motion that exhibit enhanced $\text{SL}\left(2,\mathbb{R}\right)$ Love symmetries that explain the vanishing of the static scalar Love numbers in the resonant cases. These Love symmetries can be interpreted as local $\text{SL}\left(2,\mathbb{R}\right)\times\text{SL}\left(2,\mathbb{R}\right)$ near-zone symmetries spontaneously broken down to global $\text{SL}\left(2,\mathbb{R}\right)\times U\left(1\right)$ symmetries by the periodic identification of the azimuthal angles. We also discover an infinite-dimensional extension of the Love symmetry into $\text{SL}\left(2,\mathbb{R}\right)\ltimes\hat{U}\left(1\right)_{\mathcal{V}}^2$ that contains both Love symmetries as particular subalgebras, along with a family of $\text{SL}\left(2,\mathbb{R}\right)$ subalgebras that reduce to the exact near-horizon Myers-Perry black hole isometries in the extremal limit. Finally, we show that the Love symmetries acquire a geometric interpretation as isometries of subtracted (effective) black hole geometries that preserve the internal structure of the black hole and interpret these non-extremal $\text{SL}\left(2,\mathbb{R}\right)$ structures as remnants of the enhanced isometry of the near-horizon extremal geometries.Comment: 45+16 pages, 3 Figure

Second-line antiretroviral therapy in a workplace and community-based treatment programme in South Africa: determinants of virological outcome.

: Background: As antiretroviral treatment (ART) programmes in resource-limited settings mature, more patients are experiencing virological failure. Without resistance testing, deciding who should switch to second-line ART can be difficult. The consequences for second-line outcomes are unclear. In a workplace- and community-based multi-site programme, with 6-monthly virological monitoring, we describe outcomes and predictors of viral suppression on second-line, protease inhibitor-based ART.Methods: We used prospectively collected clinic data from patients commencing first-line ART between 1/1/03 and 31/12/08 to construct a study cohort of patients switched to second-line ART in the presence of a viral load (VL) ?400 copies/ml. Predictors of VL&lt;400 copies/ml within 15 months of switch were assessed using modified Poisson regression to estimate risk ratios.Results: 205 workplace patients (91.7% male; median age 43 yrs) and 212 community patients (38.7% male; median age 36 yrs) switched regimens. At switch compared to community patients, workplace patients had a longer duration of viraemia, higher VL, lower CD4 count, and higher reported non-adherence on first-line ART. Non-adherence was the reported reason for switching in a higher proportion of workplace patients. Following switch, 48.3% (workplace) and 72.0% (community) achieved VL&lt;400, with non-adherence (17.9% vs. 1.4%) and virological rebound (35.6% vs. 13.2% with available measures) reported more commonly in the workplace programme. In adjusted analysis of the workplace programme, lower switch VL and younger age were associated with VL&lt;400. In the community programme, shorter duration of viraemia, higher CD4 count and transfers into programme on ART were associated with VL&lt;400.Conclusion: High levels of viral suppression on second-line ART can be, but are not always, achieved in multi-site treatment programmes with both individual- and programme-level factors influencing outcomes. Strategies to support both healthcare workers and patients during this switch period need to be evaluated; sub-optimal adherence, particularly in the workplace programme must be addressed