Evaluation of appendicitis risk prediction models in adults with suspected appendicitis

Background Appendicitis is the most common general surgical emergency worldwide, but its diagnosis remains challenging. The aim of this study was to determine whether existing risk prediction models can reliably identify patients presenting to hospital in the UK with acute right iliac fossa (RIF) pain who are at low risk of appendicitis. Methods A systematic search was completed to identify all existing appendicitis risk prediction models. Models were validated using UK data from an international prospective cohort study that captured consecutive patients aged 16–45 years presenting to hospital with acute RIF in March to June 2017. The main outcome was best achievable model specificity (proportion of patients who did not have appendicitis correctly classified as low risk) whilst maintaining a failure rate below 5 per cent (proportion of patients identified as low risk who actually had appendicitis). Results Some 5345 patients across 154 UK hospitals were identified, of which two‐thirds (3613 of 5345, 67·6 per cent) were women. Women were more than twice as likely to undergo surgery with removal of a histologically normal appendix (272 of 964, 28·2 per cent) than men (120 of 993, 12·1 per cent) (relative risk 2·33, 95 per cent c.i. 1·92 to 2·84; P < 0·001). Of 15 validated risk prediction models, the Adult Appendicitis Score performed best (cut‐off score 8 or less, specificity 63·1 per cent, failure rate 3·7 per cent). The Appendicitis Inflammatory Response Score performed best for men (cut‐off score 2 or less, specificity 24·7 per cent, failure rate 2·4 per cent). Conclusion Women in the UK had a disproportionate risk of admission without surgical intervention and had high rates of normal appendicectomy. Risk prediction models to support shared decision‐making by identifying adults in the UK at low risk of appendicitis were identified

Page Kidney phenomenon following kidney transplant, secondary to acute postsurgical sub capsular hematoma compression: A case report

Page kidney is one of secondary arterial hypertension forms and it is due to external compression of renal parenchyma. Hematomas, masses or fluid collection, that lead to activation of the renin-angiotensin-aldosterone system, resulting in systemic hypertension and then renal failure are the main causes. Nowadays higher necessity of kidney transplants led to more frequent use of marginal grafts, exposed to major risk of primary non function, delayed graft function or acute post-surgical complications such as capsular detachment and following hematoma. Page effect must be suspected when we notice serum creatinine increase, diuresis contraction and arterial hypertension. Doppler ultrasound (DUS) could allow diagnosis but CT scan may detect even very small hematomas that require urgent surgical drainage in order to obtain rapid recovery of renal function. We present the case of a 61-year-old man, with end-stage renal failure secondary to focal glomerulosclerosis, who underwent kidney transplantation from a deceased heart beating expanded criteria donor in October 2015. On postoperative day thirteen we observed a rapid and severe increase of serum creatinine, and for this reason patient underwent surgery for hematoma evacuation. During the immediate postoperative time we observed a rapid decrease of serum creatinine until stabilization in post-operative day four