658 research outputs found
Evidence for narrow resonant structures at and GeV in real Compton scattering off the proton
First measurement of the beam asymmetry for Compton scattering off
the proton in the energy range GeV is presented. The
data reveals two narrow structures at and
GeV. They may signal narrow resonances with masses near
and GeV, or they may be generated by the sub-threshold
and production. Their decisive identification requires additional
theoretical and experimental efforts.Comment: Published versio
Development and characterization of an amorphous solid dispersion of furosemide in the form of a sublingual bioadhesive film to enhance bioavailability
Administered by an oral route, Furosemide (FUR), a diuretic used in several edematous states and hypertension, presents bioavailability problems, reported as a consequence of an erratic gastrointestinal absorption due to various existing polymorphic forms and low and pH-dependent solubility. A mucoadhesive sublingual fast-dissolving FUR based film has been developed and evaluated in order to optimize the bioavailability of FUR by increasing solubility and guaranteeing a good dissolution reproducibility. The Differential Scanning Calorimetry (DSC) analyses confirmed that the film prepared using the solvent casting method entrapped FUR in the amorphous state. As a solid dispersion, FUR increases its solubility up to 28.36 mg/mL. Drug content, thickness, and weight uniformity of film were also evaluated. The measured Young\ue2\u80\u99s Modulus, yield strength, and relative elongation of break percentage (EB%) allowed for the classification of the drug-loaded film as an elastomer. Mucoadhesive strength tests showed that the force to detach film from mucosa grew exponentially with increasing contact time up to 7667 N/m2. FUR was quickly discharged from the film following a trend well fitted with the Weibull kinetic model. When applied on sublingual mucosa, the new formulation produced a massive drug flux in the systemic compartment. Overall, the proposed sublingual film enhances drug solubility and absorption, allowing for the prediction of a rapid onset of action and reproducible bioavailability in its clinical application
Stochastic Resonance in Two Dimensional Landau Ginzburg Equation
We study the mechanism of stochastic resonance in a two dimensional Landau
Ginzburg equation perturbed by a white noise. We shortly review how to
renormalize the equation in order to avoid ultraviolet divergences. Next we
show that the renormalization amplifies the effect of the small periodic
perturbation in the system. We finally argue that stochastic resonance can be
used to highlight the effect of renormalization in spatially extended system
with a bistable equilibria
Evidence for Narrow N*(1685) Resonance in Quasifree Compton Scattering on the Neutron
The first study of quasi-free Compton scattering on the neutron in the energy
range of GeV is presented. The data reveals a narrow
peak at GeV. This result, being considered in conjunction with
the recent evidence for a narrow structure at GeV in the
photoproduction on the neutron, suggests the existence of a new nucleon
resonance with unusual properties: the mass GeV, the narrow width
MeV, and the much stronger photoexcitation on the neutron than
on the proton.Comment: Replaced with the version published in Phys. Rev.
Eta photoproduction off the neutron at GRAAL: Evidence for a resonant structure at W=1.67 GeV
New (preliminary) data on eta photoproduction off the neutron are presented.
These data reveal a resonant structure at W=1.67 GeV.Comment: 8 pages, 4 figures. Published in Proceedings of Workshop on the
Physics of Excited Nucleons NSTAR2004, Grenoble, France, March 24 - 27,
pg.19
Eta photoproduction off the neutron at GRAAL
The gamma n -> eta n quasi-free cross section reveals a resonant structure at
W ~ 1.675 GeV. This structure may be a manifestation of a baryon resonance. A
priori its properties, the possibly narrow width and the strong photocoupling
to the neutron, look surprising. This structure may also signal the existence
of a narrow state.Comment: To appear in Proceedings of Workshop on the Physics of Excited
Nucleons NSTAR2005, 12 - 15 October 2005, Tallahassee, Florida, US
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