Single fraction radiosurgery using Rapid Arc for treatment of intracranial targets

<p>Abstract</p> <p>Background</p> <p>Stereotactic-Radio-Surgery (SRS) using Conformal-Arc-Therapy (CAT) is a well established irradiation technique for treatment of intracranial targets. Although small safety margins are required because of very high accuracy of patient positioning and exact online localisation, there are still disadvantages like long treatment time, high number of monitor units (MU) and covering of noncircular targets. This planning study analysed whether Rapid Arc (RA) with stereotactic localisation for single-fraction SRS can solve these problems.</p> <p>Methods</p> <p>Ten consecutive patients were treated with Linac-based SRS. Eight patients had one or more brain metastases. The other patients presented a symptomatic vestibularis schwannoma and an atypic meningeoma. For all patients, two plans (CAT/RA) were calculated and analysed.</p> <p>Results</p> <p>Conformity was higher for RA with additional larger low-dose areas. Furthermore, RA reduced the number of MU and the treatment time for all patients. Dose to organs at risk were equal or slightly higher using RA in comparison to CAT.</p> <p>Conclusions</p> <p>RA provides a new alternative for single-fraction SRS irradiation combining advantages of short treatment time with lower number of MU and better conformity in addition to accuracy of stereotactic localisation in selected cases with uncomplicated clinical realization.</p

Ubiquinone Analogs: A Mitochondrial Permeability Transition Pore-Dependent Pathway to Selective Cell Death

International audienceBACKGROUND: Prolonged opening of the mitochondrial permeability transition pore (PTP) leads to cell death. Various ubiquinone analogs have been shown to regulate PTP opening but the outcome of PTP regulation by ubiquinone analogs on cell fate has not been studied yet. METHODOLOGY/PRINCIPAL FINDINGS: The effects of ubiquinone 0 (Ub(0)), ubiquinone 5 (Ub(5)), ubiquinone 10 (Ub(10)) and decyl-ubiquinone (DUb) were studied in freshly isolated rat hepatocytes, cultured rat liver Clone-9 cells and cancerous rat liver MH1C1 cells. PTP regulation by ubiquinones differed significantly in permeabilized Clone-9 and MH1C1 cells from that previously reported in liver mitochondria. Ub(0) inhibited PTP opening in isolated hepatocytes and Clone-9 cells, whereas it induced PTP opening in MH1C1 cells. Ub(5) did not affect PTP opening in isolated hepatocytes and MH1C1 cells, but it induced PTP opening in Clone-9 cells. Ub(10) regulated PTP in isolated hepatocytes, whereas it did not affect PTP opening in Clone-9 and MH1C1 cells. Only DUb displayed the same effect on PTP regulation in the three hepatocyte lines tested. Despite such modifications in PTP regulation, competition between ubiquinones still occurred in Clone-9 and MH1C1 cells. As expected, Ub(5) induced a PTP-dependent cell death in Clone-9, while it did not affect MH1C1 cell viability. Ub(0) induced a PTP-dependent cell death in MH1C1 cells, but was also slightly cytotoxic in Clone-9 by an oxidative stress-dependent mechanism. CONCLUSIONS/SIGNIFICANCE: We found that various ubiquinone analogs regulate PTP in different ways depending on the cell studied. We took advantage of this unique property to develop a PTP opening-targeted strategy that leads to cell death specifically in cells where the ubiquinone analog used induces PTP opening, while sparing the cells in which it does not induce PTP opening

Screening of catalysts for the oxidative dehydrogenation of ethyl lactate to ethyl pyruvate, and optimization of the best catalysts

SSCI-VIDE+ECI2D+JMIInternational audienceEthyl lactat

Preparation of supported H3PW12040.6H2O for thiophenic compounds alkylation in FCC gasoline

International audienceIn FCC gasolines, thiophenic compounds alkylation with olefins of the feed followed by distillation of heavy sulfur compounds is a good alternative to classical hydrodesulfurization to eliminate sulfur. Among several acidic catalysts, silica-supported H3PW12O406H2O (HPW) has been found to be the best catalyst for the alkylation of 3-methylthiophene (3MT) with 2-methyl-2-butene (2M2B) taken as a model reaction in heterogeneous liquid phase systems at 358 K under nitrogen. The preparation of this catalyst has been optimized for this reaction and continuous catalytic tests have proved that this solid was very promising compared to traditional supported phosphoric acid or zeolites previously tested and used in industrial processes

Efficient catalysts for simultaneous dehydration of light alcohols in gas phase

SSCI-VIDE+ECI2D+JMIInternational audienc

Chemical vapor deposition (DLI-CVD) and characterization of multiphasic molybdate-based catalysts for propene oxidation

fffInternational audienceliste mot clef

Gas phase dehydration of 3-hydroxybutanone on orthophosphate catalysts for bio-based production of butenone for a sustainable industrial route to vitamin A

RMN+ECI2D+CLO:LCS:JMIInternational audienceAcetoi