4 research outputs found
CHARACTERIZATION OF CENTRAL AND EFFECTOR CD4βΊ MEMORY CELLS IN PSORIASIS
Psoriasis is a chronic autoimmune disease in which the skin and joints are involved in the pathological process. It was found that the recurrence of rashes in this disease occurs due to the resident memory cells of the skin. The number of CD4+CCR3+ effector memory cells in peripheral blood correlates with the severity of the disease. Therefore, the aim of our work is to study the phenotype of peripheral blood memory cells in patients with psoriasis.The study included 6 healthy donors: average age β 45.4 (min β 29, max β 55), women β 3, men β 3; 10 patients with psoriasis: women β 4, men β 6, average age β 37.3 (min β 23, max β 57), of which 5 patients with PASI > 10 and 5 patients with PASI < 10. The exclusion criteria for the study were the presence of autoimmune, oncological and hematological diseases, systemic therapy with immunosuppressive drugs for 1 month. Patients signed informed consent to participate in the study. Isolation of peripheral blood mononuclear cells was performed in a density gradient of ficoll-urographin (p = 1.082 g/L). Then cells were stained with fluorochrome-conjugated monoclonal antibodies to surface markers of central (Tcm) and effector (Tem) CD4+ memory cells (CD4, CD45RO, CD197), the Ξ±-chain of the IL-7 receptor (CD127), and the Ξ³-chain of the IL-7 receptor (CD132). Statistical analysis of the data obtained was performed using the Statistica 6.0 software package.The percent of Tcm in the peripheral blood of donors was 33.4% (in β 18.2, max β 43.7), Tem β 28.7% (min β 13.6, max β 38.9), in patients with psoriasis: Tcm β 28.65% (min β 13.3, max β 59.6), Tem β 21.5% (min β 9.3, max β 38.6). In the peripheral blood of patients with psoriasis, among the central CD4+ memory cells, the proportion of CD127+CD132- -cells is 26.00%, CD127+CD132+ β 1.69%, CD127+CD132- β 69.00%, CD127- CD132+ β 1.94%. Among effector CD4+ memory cells, the proportion of CD127+CD132- -cells is 23.58%, CD127+CD132+ β 1.18%, CD127+CD132- β 69.84%, CD127- CD132+ β 0.70%. A direct correlation was found between the number of CD127- CD132+ central memory cells and the PASI value (r = 0.639, p < 0.05).In patients with psoriasis, the proportion of central memory cells is higher than in healthy donors, while the number of effector memory cells is lower. A direct correlation was found between the number of central cells expressing the Ξ³-chain of the IL-7 receptor and the severity of the disease. Activated memory cells are characterized by high expression of CD132. It can be assumed that this population of memory cells plays a role in maintaining autoimmune inflammation in patients with this disease, and also participates in the repopulation of skin resident memory cells
Π‘ΠΎΠ²ΡΠ΅ΠΌΠ΅Π½Π½ΠΎΠ΅ ΡΠΎΡΡΠΎΡΠ½ΠΈΠ΅ ΠΌΠ΅ΡΠΎΠ΄ΠΎΠ² ΠΊΠΎΡΡΠ΅ΠΊΡΠΈΠΈ ΠΈΠ½Π²ΠΎΠ»ΡΡΠΈΠΎΠ½Π½ΡΡ ΠΈΠ·ΠΌΠ΅Π½Π΅Π½ΠΈΠΉ ΠΊΠΎΠΆΠΈ ΠΈ ΠΌΠ΅ΡΡΠΎ ΡΠΎΡΠΎΠ΄ΠΈΠ½Π°ΠΌΠΈΡΠ΅ΡΠΊΠΎΠΉ ΡΠ΅ΡΠ°ΠΏΠΈΠΈ ΡΡΠ΅Π΄ΠΈ Π½ΠΈΡ
This work is a review of modern scientific data on the process of aging, as well as the prospect of using photodynamic therapy for correction of involutional skin changes in the age cohorts, cohorts with a burdened medical history, including cancerous and precancerous skin neoplasms. The data on the predicted increase in life expectancy and, as a consequence, the potential risk of pathologies, including those with skin localization, progression of malignancy processes, as well as the formation of de novo elements, is presented. The increase in life expectancy also demonstrates the socialization of the elderly population, along with the increasing need for correction of involutional skin changes. However, considering the risks associated with the chronic diseases and increased malignancy in this cohort, methods have to be carefully selected. One such technique is photodynamic therapy (PDT). PDT is actively used in oncology, and recently has been increasingly showing its aesthetic effectiveness. It can be predictably used not only on cancer patients, but also in an age cohort.ΠΠ°Π½Π½Π°Ρ ΡΠ°Π±ΠΎΡΠ° ΠΏΡΠ΅Π΄ΡΡΠ°Π²Π»ΡΠ΅Ρ ΡΠΎΠ±ΠΎΠΉ ΠΎΠ±Π·ΠΎΡ ΡΠΎΠ²ΡΠ΅ΠΌΠ΅Π½Π½ΡΡ
Π½Π°ΡΡΠ½ΡΡ
Π΄Π°Π½Π½ΡΡ
ΠΎ ΠΏΡΠΎΡΠ΅ΡΡΠ°Ρ
ΡΡΠ°ΡΠ΅Π½ΠΈΡ ΠΊΠΎΠΆΠΈ, Π° ΡΠ°ΠΊΠΆΠ΅ ΠΎ ΠΏΠ΅ΡΡΠΏΠ΅ΠΊΡΠΈΠ²Π΅ ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½ΠΈΡ ΠΌΠ΅ΡΠΎΠ΄Π° ΡΠΎΡΠΎΠ΄ΠΈΠ½Π°ΠΌΠΈΡΠ΅ΡΠΊΠΎΠΉ ΡΠ΅ΡΠ°ΠΏΠΈΠΈ Π΄Π»Ρ ΠΊΠΎΡΡΠ΅ΠΊΡΠΈΠΈ ΠΈΠ½Π²ΠΎΠ»ΡΡΠΈΠΎΠ½Π½ΡΡ
ΠΈΠ·ΠΌΠ΅Π½Π΅Π½ΠΈΠΉ ΠΊΠΎΠΆΠΈ Ρ Π²ΠΎΠ·ΡΠ°ΡΡΠ½ΠΎΠ³ΠΎ Π½Π°ΡΠ΅Π»Π΅Π½ΠΈΡ. ΠΡΠΈΠ²ΠΎΠ΄ΡΡΡΡ Π΄Π°Π½Π½ΡΠ΅ ΠΏΡΠΎΠ³Π½ΠΎΠ·ΠΈΡΡΠ΅ΠΌΠΎΠ³ΠΎ ΡΠ²Π΅Π»ΠΈΡΠ΅Π½ΠΈΡ ΠΏΡΠΎΠ΄ΠΎΠ»ΠΆΠΈΡΠ΅Π»ΡΠ½ΠΎΡΡΠΈ ΠΆΠΈΠ·Π½ΠΈ ΠΈ, ΠΊΠ°ΠΊ ΡΠ»Π΅Π΄ΡΡΠ²ΠΈΠ΅, ΠΏΠΎΡΠ΅Π½ΡΠΈΠ°Π»ΡΠ½ΠΎΠ³ΠΎ ΡΠΈΡΠΊΠ° Π²ΠΎΠ·Π½ΠΈΠΊΠ½ΠΎΠ²Π΅Π½ΠΈΡ ΠΏΠ°ΡΠΎΠ»ΠΎΠ³ΠΈΠΉ, Π² ΡΠΎΠΌ ΡΠΈΡΠ»Π΅ ΠΊΠΎΠΆΠ½ΠΎΠΉ Π»ΠΎΠΊΠ°Π»ΠΈΠ·Π°ΡΠΈΠΈ. Π£Π²Π΅Π»ΠΈΡΠ΅Π½ΠΈΠ΅ ΠΏΡΠΎΠ΄ΠΎΠ»ΠΆΠΈΡΠ΅Π»ΡΠ½ΠΎΡΡΠΈ ΠΆΠΈΠ·Π½ΠΈ ΡΠ°ΠΊΠΆΠ΅ Π΄Π΅ΠΌΠΎΠ½ΡΡΡΠΈΡΡΠ΅Ρ ΠΈ ΡΠΎΡΠΈΠ°Π»ΠΈΠ·Π°ΡΠΈΡ ΠΏΠΎΠΆΠΈΠ»ΠΎΠ³ΠΎ Π½Π°ΡΠ΅Π»Π΅Π½ΠΈΡ, Π²ΠΌΠ΅ΡΡΠ΅ Ρ ΡΠ΅ΠΌ Π²ΠΎΠ·ΡΠ°ΡΡΠ°ΡΡΡΡ ΠΏΠΎΡΡΠ΅Π±Π½ΠΎΡΡΡ Π² ΠΏΡΠ΅ΠΎΠ±ΡΠ°ΠΆΠ΅Π½ΠΈΠΈ ΠΈ ΠΊΠΎΡΡΠ΅ΠΊΡΠΈΠΈ ΠΈΠ½Π²ΠΎΠ»ΡΡΠΈΠΎΠ½Π½ΡΡ
ΠΈΠ·ΠΌΠ΅Π½Π΅Π½ΠΈΠΉ ΠΊΠΎΠΆΠΈ, Π½ΠΎ, ΡΡΠΈΡΡΠ²Π°Ρ ΡΠΈΡΠΊΠΈ Π² ΡΠ²ΡΠ·ΠΈ Ρ Π½Π°Π»ΠΈΡΠΈΠ΅ΠΌ Ρ
ΡΠΎΠ½ΠΈΡΠ΅ΡΠΊΠΈΡ
Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΠΉ ΠΈ Π²ΠΎΠ·ΡΠ°ΡΡΠ°ΡΡΠ΅ΠΉ ΠΌΠ°Π»ΠΈΠ³Π½ΠΈΠ·Π°ΡΠΈΠΈ Π΄Π°Π½Π½ΠΎΠΉ ΠΊΠΎΠ³ΠΎΡΡΡ, ΡΠ»Π΅Π΄ΡΠ΅Ρ ΡΡΠ°ΡΠ΅Π»ΡΠ½ΠΎ ΠΏΠΎΠ΄Π±ΠΈΡΠ°ΡΡ ΠΌΠ΅ΡΠΎΠ΄ΠΈΠΊΠΈ, ΡΡΠΈΡΡΠ²Π°Ρ Π²ΡΡΠ΅ΠΏΠ΅ΡΠ΅ΡΠΈΡΠ»Π΅Π½Π½ΡΠ΅ ΠΎΡΠΎΠ±Π΅Π½Π½ΠΎΡΡΠΈ. ΠΠ΄Π½ΠΈΠΌ ΠΈΠ· ΡΠ°ΠΊΠΈΡ
ΠΌΠ΅ΡΠΎΠ΄ΠΎΠ² ΡΠ²Π»ΡΠ΅ΡΡΡ ΡΠΎΡΠΎΠ΄ΠΈΠ½Π°ΠΌΠΈΡΠ΅ΡΠΊΠ°Ρ ΡΠ΅ΡΠ°ΠΏΠΈΡ. Π€ΠΎΡΠΎΠ΄ΠΈΠ½Π°ΠΌΠΈΡΠ΅ΡΠΊΠ°Ρ ΡΠ΅ΡΠ°ΠΏΠΈΡ Π°ΠΊΡΠΈΠ²Π½ΠΎ ΠΏΡΠΈΠΌΠ΅Π½ΡΠ΅ΡΡΡ Π² ΠΎΠ½ΠΊΠΎΠ»ΠΎΠ³ΠΈΠΈ, Π° Π² ΠΏΠΎΡΠ»Π΅Π΄Π½Π΅Π΅ Π²ΡΠ΅ΠΌΡ Π²ΡΠ΅ ΡΠ°ΡΠ΅ ΠΏΠΎΠΊΠ°Π·ΡΠ²Π°Π΅Ρ ΡΠ²ΠΎΡ ΡΡΡΠ΅ΠΊΡΠΈΠ²Π½ΠΎΡΡΡ Π² ΡΡΡΠ΅ΡΠΈΡΠ΅ΡΠΊΠΎΠΌ Π½Π°ΠΏΡΠ°Π²Π»Π΅Π½ΠΈΠΈ, ΡΠΎΠΎΡΠ²Π΅ΡΡΡΠ²Π΅Π½Π½ΠΎ ΠΏΡΠΎΠ³Π½ΠΎΠ·ΠΈΡΡΠ΅ΠΌΠΎ ΠΌΠΎΠΆΠ΅Ρ ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°ΡΡΡΡ Π½Π΅ ΡΠΎΠ»ΡΠΊΠΎ Ρ ΠΎΠ½ΠΊΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΡ
Π±ΠΎΠ»ΡΠ½ΡΡ
, Π½ΠΎ ΠΈ Π²ΠΎΠ·ΡΠ°ΡΡΠ½ΠΎΠΉ ΠΊΠΎΠ³ΠΎΡΡΡ
Π€ΠΎΡΠΎΠ΄ΠΈΠ½Π°ΠΌΠΈΡΠ΅ΡΠΊΠ°Ρ ΡΠ΅ΠΏΠ°ΡΠ°ΡΠΈΠ²Π½Π°Ρ ΡΠ΅Π³Π΅Π½Π΅ΡΠ°ΡΠΈΡ ΠΊΠΎΠΆΠΈ Ρ ΠΏΡΠΈΠΌΠ΅Π½Π΅Π½ΠΈΠ΅ΠΌ Π½Π°ΡΡΠΆΠ½ΠΎΠ³ΠΎ Π³Π΅Π»Ρ-ΡΠΎΡΠΎΡΠ΅Π½ΡΠΈΠ±ΠΈΠ»ΠΈΠ·Π°ΡΠΎΡΠ° Π½Π° ΠΎΡΠ½ΠΎΠ²Π΅ Ρ Π»ΠΎΡΠΈΠ½Π° Π΅6
The results of a study of the clinical effectiveness of the correction of involutional changes in the skin by the method of photodynamic therapy (PDT) with the use of a photosensitizer gel (PS), the active substance of which is the trismeglumine salt of chlorin e6, are presented. The data of fluorescence spectroscopy for monitoring the level of PS fluorescence in order to determine the optimal time of its exposure are demonstrated. The study of the optimal exposure time involved 80 patients with different skin phototypes. The study of the effectiveness of PDT involved 42 patients aged 44β68 years with signs of chrono- and photoaging. The PDT procedure was performed by irradiating the entire surface treated with the PS with a power density of 100 mW/cm2, a light dose of 120β140 J/cm2, a laser radiation wavelength of 660 nm, and a light beam area of 400β800 cm2. It was found that exposure to PS for 10β20 min gives the highest fluorescence and does not depend on the skin phototype. The clinical effect of PDT was achieved in 85.7% of patients; there were no negative subjective sensations. Moisture metrics increased on the skin of the face by 53%, reaching the control values in young healthy volunteers, on the skin of the hands - by 64%. Elastometry indicators on the skin of the face and hands increased by 19% and 16%, respectively. Thus, the PDT procedure with PS based on chlorin e6 is an effective method for correcting involutional changes in the skin, leads to a pronounced clinical effect, improves the parameters of skin moisture measurement and elastometry, and passes without undesirable local reactions. Optical coherence tomography showed an increase in collagen ordering.ΠΡΠ΅Π΄ΡΡΠ°Π²Π»Π΅Π½Ρ ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΡ ΠΈΠ·ΡΡΠ΅Π½ΠΈΡ ΠΊΠ»ΠΈΠ½ΠΈΡΠ΅ΡΠΊΠΎΠΉ ΡΡΡΠ΅ΠΊΡΠΈΠ²Π½ΠΎΡΡΠΈ ΠΊΠΎΡΡΠ΅ΠΊΡΠΈΠΈ ΠΈΠ½Π²ΠΎΠ»ΡΡΠΈΠΎΠ½Π½ΡΡ
ΠΈΠ·ΠΌΠ΅Π½Π΅Π½ΠΈΠΉ ΠΊΠΎΠΆΠΈ ΠΌΠ΅ΡΠΎΠ΄ΠΎΠΌ ΡΠΎΡΠΎΠ΄ΠΈΠ½Π°ΠΌΠΈΡΠ΅ΡΠΊΠΎΠΉ ΡΠ΅ΡΠ°ΠΏΠΈΠΈ (Π€ΠΠ’) Ρ ΠΏΡΠΈΠΌΠ΅Π½Π΅Π½ΠΈΠ΅ΠΌ Π³Π΅Π»ΡβΡΠΎΡΠΎΡΠ΅Π½ΡΠΈΠ±ΠΈΠ»ΠΈΠ·Π°ΡΠΎΡΠ° (Π€Π‘), Π°ΠΊΡΠΈΠ²Π½ΡΠΌ Π²Π΅ΡΠ΅ΡΡΠ²ΠΎΠΌ ΠΊΠΎΡΠΎΡΠΎΠ³ΠΎ ΡΠ²Π»ΡΠ΅ΡΡΡ ΡΡΠΈΡΠΌΠ΅Π³Π»ΡΠΌΠΈΠ½ΠΎΠ²Π°Ρ ΡΠΎΠ»Ρ Ρ
Π»ΠΎΡΠΈΠ½Π° Π΅6. ΠΡΠΎΠ΄Π΅ΠΌΠΎΠ½ΡΡΡΠΈΡΠΎΠ²Π°Π½Ρ Π΄Π°Π½Π½ΡΠ΅ ΡΠ»ΡΠΎΡΠ΅ΡΡΠ΅Π½ΡΠ½ΠΎΠΉ ΡΠΏΠ΅ΠΊΡΡΠΎΡΠΊΠΎΠΏΠΈΠΈ Π΄Π»Ρ ΠΊΠΎΠ½ΡΡΠΎΠ»Ρ ΡΡΠΎΠ²Π½Ρ ΡΠ»ΡΠΎΡΠ΅ΡΡΠ΅Π½ΡΠΈΠΈ Π€Π‘ Ρ ΡΠ΅Π»ΡΡ ΠΎΠΏΡΠ΅Π΄Π΅Π»Π΅Π½ΠΈΡ ΠΎΠΏΡΠΈΠΌΠ°Π»ΡΠ½ΠΎΠ³ΠΎ Π²ΡΠ΅ΠΌΠ΅Π½ΠΈ Π΅Π³ΠΎ ΡΠΊΡΠΏΠΎΠ·ΠΈΡΠΈΠΈ. Π ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠΈ ΠΎΠΏΡΠΈΠΌΠ°Π»ΡΠ½ΠΎΠ³ΠΎ Π²ΡΠ΅ΠΌΠ΅Π½ΠΈ ΡΠΊΡΠΏΠΎΠ·ΠΈΡΠΈΠΈ ΡΡΠ°ΡΡΠ²ΠΎΠ²Π°Π»ΠΈ 80 ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ² Ρ ΡΠ°Π·Π»ΠΈΡΠ½ΡΠΌ ΡΠΎΡΠΎΡΠΈΠΏΠΎΠΌ ΠΊΠΎΠΆΠΈ. Π ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠΈ ΡΡΡΠ΅ΠΊΡΠΈΠ²Π½ΠΎΡΡΠΈ Π€ΠΠ’ ΡΡΠ°ΡΡΠ²ΠΎΠ²Π°Π»ΠΈ 42 ΠΏΠ°ΡΠΈΠ΅Π½ΡΠ° Π² Π²ΠΎΠ·ΡΠ°ΡΡΠ΅ 44β68 Π»Π΅Ρ Ρ ΠΏΡΠΈΠ·Π½Π°ΠΊΠ°ΠΌΠΈ Ρ
ΡΠΎΠ½ΠΎβ ΠΈ ΡΠΎΡΠΎΡΡΠ°ΡΠ΅Π½ΠΈΡ. ΠΡΠΎΡΠ΅Π΄ΡΡΡ Π€ΠΠ’ Π²ΡΠΏΠΎΠ»Π½ΡΠ»ΠΈ ΠΏΡΡΠ΅ΠΌ ΠΎΠ±Π»ΡΡΠ΅Π½ΠΈΡ Π²ΡΠ΅ΠΉ ΠΎΠ±ΡΠ°Π±Π°ΡΡΠ²Π°Π΅ΠΌΠΎΠΉ Π€Π‘ ΠΏΠΎΠ²Π΅ΡΡ
Π½ΠΎΡΡΠΈ Ρ ΠΏΠ»ΠΎΡΠ½ΠΎΡΡΡΡ ΠΌΠΎΡΠ½ΠΎΡΡΠΈ 100 ΠΌΠΡ/ΡΠΌ2, ΡΠ²Π΅ΡΠΎΠ²ΠΎΠΉ Π΄ΠΎΠ·ΠΎΠΉ 120β140 ΠΠΆ/ΡΠΌ2, Π΄Π»ΠΈΠ½Π° Π²ΠΎΠ»Π½Ρ Π»Π°Π·Π΅ΡΠ½ΠΎΠ³ΠΎ ΠΈΠ·Π»ΡΡΠ΅Π½ΠΈΡ 660 Π½ΠΌ, ΠΏΠ»ΠΎΡΠ°Π΄Ρ ΡΠ²Π΅ΡΠΎΠ²ΠΎΠ³ΠΎ ΠΏΡΡΠΊΠ° 400β800 ΡΠΌ2. Π£ΡΡΠ°Π½ΠΎΠ²Π»Π΅Π½ΠΎ, ΡΡΠΎ ΡΠΊΡΠΏΠΎΠ·ΠΈΡΠΈΡ Π€Π‘ Π² ΡΠ΅ΡΠ΅Π½ΠΈΠ΅ 10β20 ΠΌΠΈΠ½ Π΄Π°Π΅Ρ Π½Π°ΠΈΠ±ΠΎΠ»ΡΡΡΡ ΡΠ»ΡΠΎΡΠ΅ΡΡΠ΅Π½ΡΠΈΡ ΠΈ Π½Π΅ Π·Π°Π²ΠΈΡΠΈΡ ΠΎΡ ΡΠΎΡΠΎΡΠΈΠΏΠ° ΠΊΠΎΠΆΠΈ. ΠΠ»ΠΈΠ½ΠΈΡΠ΅ΡΠΊΠΈΠΉ ΡΡΡΠ΅ΠΊΡ Π€ΠΠ’ Π΄ΠΎΡΡΠΈΠ³Π½ΡΡ Ρ 85,7% ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ², ΡΡΠ±ΡΠ΅ΠΊΡΠΈΠ²Π½ΡΡ
ΠΎΡΡΡΠ΅Π½ΠΈΠΉ Π½Π΅Π³Π°ΡΠΈΠ²Π½ΠΎΠ³ΠΎ Ρ
Π°ΡΠ°ΠΊΡΠ΅ΡΠ° Π½Π΅ ΠΎΡΠΌΠ΅ΡΠ°Π»ΠΎΡΡ. ΠΠΎΠΊΠ°Π·Π°ΡΠ΅Π»ΠΈ Π²Π»Π°Π³ΠΎΠΌΠ΅ΡΡΠΈΠΈ ΡΠ²Π΅Π»ΠΈΡΠΈΠ»ΠΈΡΡ Π½Π° ΠΊΠΎΠΆΠ΅ Π»ΠΈΡΠ° Π½Π° 53%, Π΄ΠΎΡΡΠΈΠ³Π½ΡΠ² ΠΊΠΎΠ½ΡΡΠΎΠ»ΡΠ½ΡΡ
Π·Π½Π°ΡΠ΅Π½ΠΈΠΉ Ρ ΠΌΠΎΠ»ΠΎΠ΄ΡΡ
Π·Π΄ΠΎΡΠΎΠ²ΡΡ
Π΄ΠΎΠ±ΡΠΎΠ²ΠΎΠ»ΡΡΠ΅Π², Π½Π° ΠΊΠΎΠΆΠ΅ ΠΊΠΈΡΡΠ΅ΠΉ ΡΡΠΊ β Π½Π° 64%. ΠΠΎΠΊΠ°Π·Π°ΡΠ΅Π»ΠΈ ΡΠ»Π°ΡΡΠΎΠΌΠ΅ΡΡΠΈΠΈ Π½Π° ΠΊΠΎΠΆΠ΅ Π»ΠΈΡΠ° ΠΈ ΡΡΠΊ ΡΠ²Π΅Π»ΠΈΡΠΈΠ»ΠΈΡΡ Π½Π° 19% ΠΈ 16%, ΡΠΎΠΎΡΠ²Π΅ΡΡΡΠ²Π΅Π½Π½ΠΎ. Π’Π°ΠΊΠΈΠΌ ΠΎΠ±ΡΠ°Π·ΠΎΠΌ, ΠΏΡΠΎΡΠ΅Π΄ΡΡΠ° Π€ΠΠ’ Ρ Π€Π‘ Π½Π° ΠΎΡΠ½ΠΎΠ²Π΅ Ρ
Π»ΠΎΡΠΈΠ½Π° Π΅6 ΡΠ²Π»ΡΠ΅ΡΡΡ ΡΡΡΠ΅ΠΊΡΠΈΠ²Π½ΡΠΌ ΠΌΠ΅ΡΠΎΠ΄ΠΎΠΌ ΠΊΠΎΡΡΠ΅ΠΊΡΠΈΠΈ ΠΈΠ½Π²ΠΎΠ»ΡΡΠΈΠΎΠ½Π½ΡΡ
ΠΈΠ·ΠΌΠ΅Π½Π΅Π½ΠΈΠΉ ΠΊΠΎΠΆΠΈ, ΠΏΡΠΈΠ²ΠΎΠ΄ΠΈΡ ΠΊ Π²ΡΡΠ°ΠΆΠ΅Π½Π½ΠΎΠΌΡ ΠΊΠ»ΠΈΠ½ΠΈΡΠ΅ΡΠΊΠΎΠΌΡ ΡΡΡΠ΅ΠΊΡΡ, ΡΠ»ΡΡΡΠ°Π΅Ρ ΠΏΠΎΠΊΠ°Π·Π°ΡΠ΅Π»ΠΈ Π²Π»Π°Π³ΠΎΠΌΠ΅ΡΡΠΈΠΈ ΠΈ ΡΠ»Π°ΡΡΠΎΠΌΠ΅ΡΡΠΈΠΈ ΠΊΠΎΠΆΠΈ ΠΈ ΠΏΡΠΎΡ
ΠΎΠ΄ΠΈΡ Π±Π΅Π· Π½Π΅ΠΆΠ΅Π»Π°ΡΠ΅Π»ΡΠ½ΡΡ
ΠΌΠ΅ΡΡΠ½ΡΡ
ΡΠ΅Π°ΠΊΡΠΈΠΉ. ΠΡΠΈ ΠΎΠΏΡΠΈΡΠ΅ΡΠΊΠΎΠΉ ΠΊΠΎΠ³Π΅ΡΠ΅Π½ΡΠ½ΠΎΠΉ ΡΠΎΠΌΠΎΠ³ΡΠ°ΡΠΈΠΈ ΡΡΡΠ°Π½ΠΎΠ²Π»Π΅Π½ΠΎ ΡΠ²Π΅Π»ΠΈΡΠ΅Π½ΠΈΠ΅ ΡΠΏΠΎΡΡΠ΄ΠΎΡΠ΅Π½Π½ΠΎΡΡΠΈ ΠΊΠΎΠ»Π»Π°Π³Π΅Π½Π°
Current state of methods of correction of involutional changes of skin and the place of photodynamic therapy among them
This work is a review of modern scientific data on the process of aging, as well as the prospect of using photodynamic therapy for correction of involutional skin changes in the age cohorts, cohorts with a burdened medical history, including cancerous and precancerous skin neoplasms. The data on the predicted increase in life expectancy and, as a consequence, the potential risk of pathologies, including those with skin localization, progression of malignancy processes, as well as the formation of de novo elements, is presented. The increase in life expectancy also demonstrates the socialization of the elderly population, along with the increasing need for correction of involutional skin changes. However, considering the risks associated with the chronic diseases and increased malignancy in this cohort, methods have to be carefully selected. One such technique is photodynamic therapy (PDT). PDT is actively used in oncology, and recently has been increasingly showing its aesthetic effectiveness. It can be predictably used not only on cancer patients, but also in an age cohort