Choice of parameters and stability of nonlinear vibration isolation device

Work of active vibration isolation devices with single-mass electromagnetic suspension taking into account of real characteristics of the voltage regulators is described. The analytical researches are carried out; the areas of stability of work of nonlinear vibration isolation device are defined

Ideographic dictionaries in the practice of teaching linguistic disciplines

Dictionaries with systematic vocabulary by thematic or semantic classes are in demand in school and university practice of teaching Russian as a foreign language, Russian as a non-native language, and foreign languages. Such dictionaries can be used to replenish the students' vocabulary and theoretically comprehend the vocabulary as a system of interacting word classes. Ideographic dictionaries serve as a means of studying linguistic conceptualization and categorization of the world and, therefore, they become a source of linguistic and cultural information relevant to intercultural communication. Ideographic dictionaries are active type dictionaries, which contributes to the implementation of communicative tasks in the learning process. The principle of consistency of ideographic dictionaries corresponds to the organization of the person's cognitive system and the mental lexicon. The article discusses the concept of ideographic dictionaries created by scientists of the Ural semantic school under the guidance of L. G. Babenko. This concept is based on the denotative approach to the formation of word classes. Words in the same class are interpreted through a basic identifier, for example, dictionary interpretations of all behavioral verbs begin with the identifier 'behave'. The ideographic principle allows to avoid the circle in the interpretation of words. The macrostructure of the ideographic dictionary is organized according to the principles of hierarchy and intersection of semantic classes. The study of the ideographic dictionary is considered in the aspect of its use in the educational process in two directions: in the study of the systematic language organization and for the development of communication skills. Examples of tasks aimed at the formation of professional competencies of a philologist student are presented. © 2019 LLC Ecological Help. All rights reserved

Role of morphogenic proteins of the WNT signaling pathway in coronary artery disease

In recent years, researchers’ attention has been directed to the WNT signaling pathway study, which regulates embryogenesis processes and is involved in pathological condition development. The role of morphogenic proteins of WNT signaling pathway in the cardiovascular pathology genesis is practically not clear. The research aim was a comprehensive study of the main proteins of WNT signaling pathway (β-catenin, sclerostin, GSK-3α, GSK-3β, WIF-1 and DVL-1) in the blood serum of 353 patients with coronary artery disease acute forms who were treated at the Orel regional vascular center from 2019 to 2021, and 50 healthy individuals. A comprehensive analysis included an assessment of clinical, laboratory and instrumental parameters in the framework of current clinical guidelines, as well as an immunological examination to determine the morphogenic proteins of WNT signaling by enzyme immunoassay. The results showed a wide variability in the values of morphogenic proteins of WNT signaling pathway in the patient’s blood serum. The levels of β-catenin, WIF-1 and DVL-1 significantly exceeded those obtained in healthy individuals, while the concentrations of sclerostin and GSK-3β did not differ significantly from them. The level of GSK-3α of patients was twice lower than in healthy individuals. The highest sclerostin concentrations were found in patients with existing calcification of the aortic valve leaflets and aortic walls. Acute coronary syndrome unfavorable course was observed in patients with both extremely high and extremely low WIF-1 levels. Significant correlations were established between the level of morphogenic proteins of WNT signaling pathway and lipid metabolism, as well as myocardial remodeling. The obtained data on changes in the protein production of WNT signaling pathway allow us to expand our understanding of the molecular aspects of the immunopathogenesis of myocardial remodeling in coronary artery disease, increase the predictive potential for cardiovascular disease diagnosis and determine the vector for further development of cardioimmunology determination

Лингвистическая экспертиза художественного текста по делам о противодействии экстремизму

The author examines various aspects of forensic assessment of literary texts in cases dealing with extremism prevention. De!ning characteristics of this type of forensic evidence are described, as well as problems of literary communication analysis and the use of semantic and communicative/pragmatic analysis. Рассматриваются вопросы экспертного исследования художественных текстов по делам, связанным с противодействием экстремизму. Специфика объекта исследования, проблемы анализа художественной коммуникации, использования семантического и коммуникативно-прагматического анализа.

Cognitive Dissonance, Depression, Brainwreck, and Other Psychological Terms Outside Psychological Discourse

The report examines the usage of psychological terms in the media and everyday communication, producing lexical neologisms that refer to the emotional sphere of a person and name various deviant phychological states. The development of a special type of word meaning is considered.Рассматривается процесс использования психологических терминов в медийном и разговорном дискурсах, который приводит к появлению лексических неологизмов, характеризующих эмоциональную сферу человека и связанных с номинацией необычных состояний. Представлено формирование особого типа значения слова.Исследование выполнено при финансовой поддержке РФФИ в рамках научного проекта № 19-012-00458 «Отношения тождества и противоположности: интеграция ментальных пространств в лексикографическом, структурно-семантическом и когнитивно-дискурсивном освещении»

Communicative and Pragmatic Specificity of Self-Presentation Models (by Example of Stephen Fry’s Microblog “Twitter”)

The models of self-presentation as a way of constructing identity and a form of self-reflection are considered. The empirical material for the study was S. Fry’s self-identifying statements in the social network “Twitter,” which is estimated as the most egocentric discourse. Lexical-stylistic and grammatical means of self-presentation are analyzed, classification of models and structures of self-presentation is created. Particular attention is paid to the bright features of S. Fry’s idiostyle, such as the ironic self-identification with the help of special autoreference formulas. The question is raised about the possibility of gaming use of self-presentation statements to draw attention to his own figure, to construct identity through the creative use of language resources. Attention is paid to how the gaming self-presentation is used to create a speech mask, the construction of a special artistic image in which self-centeredness, awareness of self-importance is combined with an ironic attitude to himself. Conclusions about the language personality of S. Fry, idiocentrics microblog “Twitter” and the referential meanings of expressions, characterized by a communicative orientation

ROLE OF GSK-3 IN Wnt/β-CATENIN SIGNALING PATHWAY IN OBESITY

The complexity of the adipogenesis mechanism results from the impact of multiple cues, among which an important place is held by the components of the Wnt signaling pathway. The search for potential markers of the development of diseases related to obesity aroused an interest in the study of GSK-3 (glycogen synthase kinase), β-catenin. GSK-3β is an intracellular serine / threonine kinase found in the cytoplasm, nucleus, mitochondria, synthesized in all body tissues and involved in regulating metabolic processes, cell proliferation, apoptosis etc. The first of the discovered functions of GSK-3β was the regulation of glycogen synthesis. Active GSK-3β phosphorylates and thereby inhibits glycogen synthase. As a result of the insulin binding to the cell receptor via inositol-3-phosphate, protein kinase B (Akt1) is activated, which, in turn, phosphorylates and inhibits GSK-3β. In addition, GSK-3β is involved in the regulating glucose metabolism. The most important function of GSK-3β is the inhibition of the β-catenin protein. In a resting cell, GSK-3β in complex with the APC and Axin proteins binds and phosphorylates the β-catenin transcription factor, which leads to its ubiquitination and degradation. When Wnt proteins act on the cell, the Dvl protein is activated, which, by binding to GSK-3β, releases β-catenin, preventing its degradation, however, the role of GSK3α/β in the adipocyte inflammatory response has not yet been fully investigated, therefore it seems promising to study the role of GSK-3 in the Wnt/β-catenin signaling pathway in obesityThe aim of the study was to assess the activity of the components of the Wnt signaling pathway in obese patients by measuring the serum level of GSK-3 and β-catenin. There were enrolled 32 patients with progressive forms of I-III degree obesity in the absence of diabetes mellitus. The concentration of serum GSK-3α, GSK-3β, and β-catenin was measured by enzyme-linked immunoassay. Data are presented as absolute and relative (%) number of patients; arithmetic mean; medians, 1 and 3 quartiles – Ме (Q0.25-Q0.75). Obese patients contained a 7.5-fold increased serum level of GSK-3α (785 (371-1317.5) pg/ml) compared to healthy individuals 105 (102.5-110) pg/ml, (p < 0.001), paralleled with increased amount of GSK-3β, which level in obese patients was 295 (190-695) pg/ml, which is by 18.3% higher than those in healthy individuals 241 (218.75-287.5) pg/ml, p = 0.111. Amount of GSK-3 depending on the degree of obesity tended to increase, most often coupled to decreased β-catenin level which is consistent with the literature data and can be considered as a prognostic criterion for the course of pathological processes in obesity

About location of the stars that ionize nebulosities on infrared diagrams

В работе рассмотрены положение звезд, ионизующих туманности, на инфракрасных диаграммах, и влияние околозвездного поглощения на их покраснение.In this work the location of stars, ionizing nebulosities, on the infrared diagrams and the influence of circumstellar absorption on their reddening was examined