Synthesis and SomeReactions of 3-Methyl-4-aryl-1-phenyl-1H- pyrazolo[3,4-dipyrimidine-6-thiols

3-Methyl-4-aryl-1-phenyl-1H -pyrazolo[3,4-d]-pyrimidine-6-thiols( 11)were synthesised by the raction of thiourea with 3-methyl-\u27 -1-phenyl-4-arylidene-2-pyrazolin-5-ones(1) in ethanolic solution of potassium hydroxide. The mechanism of this reaction is discussed and further transformation of the products with different reagents (S-methylation, substitution of SR-group by arylamines, hydrazine, and azide) was carried out

Supervised exercise training and increased physical activity to reduce cardiovascular disease risk in women with polycystic ovary syndrome: Study protocol for a randomized controlled feasibility trial

Background: Polycystic ovary syndrome (PCOS) affects up to 20% of women and is characterised by higher amounts of visceral fat, obesity, insulin resistance, dyslipidemia and reproductive and cardiometabolic complications. Increased oxidised low-density lipoprotein (LDL) concentrations have been associated with an increased risk of cardiovascular disease (CVD)-related events. Oxidised LDL is rarely used as a marker for CVD risk in PCOS-related studies despite its widely accepted role in atherogenesis and the increased risk factors associated with PCOS. Additionally, prolonged periods of sedentary behaviour can negatively affect metabolic health. No studies have specifically examined the effects of reducing sedentary behaviour on CVD risk in PCOS with a lifestyle physical activity intervention. The aim of the current study is to measure the feasibility of a randomised controlled trial (RCT) examining the effects of supervised exercise and reducing sedentary behaviour in women with PCOS on CVD risk. Methods/design: A feasibility, exploratory RCT will be conducted. Fifty-one pre-menopausal females will be randomly allocated between an exercise group (EG), a lifestyle physical activity group (LPAG) and a control group. Participants in the EG will undertake a 12-week supervised aerobic exercise programme. The LPAG will aim to increase daily physical activity and reduce sedentary behaviour for 12 weeks. The control group will not take part in any intervention. Primary outcomes are feasibility and acceptability of the intervention and procedures. Secondary outcomes are oxidised LDL, aerobic fitness, blood lipid profile, fasting glucose and insulin, testosterone and inflammatory markers. Discussion: PCOS is associated with various increased risk factors for CVD, including hypertension, dyslipidemia, abdominal obesity, insulin resistance, and inflammation. Whether oxidised LDL has a role in this increased risk is not yet known. The present study aims to measure the feasibility of implementing structured exercise training and/or increased lifestyle physical activity in women with PCOS, so that a subsequent adequately powered RCT can be designed. The results from the study will be used to refine the interventions and determine the acceptability of the study design. A limitation is that some self-monitoring in the lifestyle physical activity group may not be reliable or replicable, for example inputting information about time spent cleaning/gardening

Controlling the quantum computational speed

The speed of quantum computation is investigated through the time evolution of the speed of the orthogonality. The external field components for classical treatment beside the detuning and the coupling parameters for quantum treatment play important roles on the computational speed. It has been shown that the number of photons has no significant effect on the speed of computation. However, it is very sensitive to the variation in both detuning and the interaction coupling parameters.Comment: 9 pages, 10 figure

On Hermite-Hermite matrix polynomials

summary:In this paper the definition of Hermite-Hermite matrix polynomials is introduced starting from the Hermite matrix polynomials. An explicit representation, a matrix recurrence relation for the Hermite-Hermite matrix polynomials are given and differential equations satisfied by them is presented. A new expansion of the matrix exponential for a wide class of matrices in terms of Hermite-Hermite matrix polynomials is proposed

The Association Between Corporate Social Performance and Corporate Financial Performance: Evidence From Kuwait

The literature on the association between corporate social performance (CSP) and corporate financial performance (CFP) fails to provide conclusive evidence regarding the nature of this relationship. Some studies found a positive while others reported a negative or neutral (no) relationship. The purpose of the present study is to expand earlier research on this relationship in the context of Kuwaiti corporations. To achieve this objective, a sample of Kuwaiti corporations is selected, representing all economic sectors, sizes and ages over a period of two years: 2018 and 2019. A disclosure index of CSP disclosure is developed, to measure corporate social performance. The results of the two regression models reveal that both ROA and ROE as measures of CFP are positively and significantly associated with CSP, while control variables (size and age) are not statistically significant at any acceptable level. These results suggest that corporate management should treat investing in social activities as a core business strategy that would pave a way for a higher financial performance and thus, maximize its stockholder’s wealth

Syntheses of 4-Substituted-3-Methyl-2-Phenylimidazoles

Reaction of the title compound I with aromatic aldehydes afforded a,b-unsaturated ketones II, which were allowed to react with cyanoacetamide, ethyl cyanoacetate, hydrazines. Treatment of I with hydrazines or amines gave V and VI