Wave Profile for Anti-force Waves with Maximum Possible Currents

In the theoretical investigation of the electrical breakdown of a gas, we apply a one-dimensional, steady state, constant velocity, three component fluid model and consider the electrons to be the main element in propagation of the wave. The electron gas temperature, and therefore the electron gas partial pressure, is considered to be large enough to provide the driving force. The wave is considered to have a shock front, followed by a thin dynamical transition region. Our set of electron fluid-dynamical equations consists of the equations of conservation of mass, momentum, and energy, plus the Poisson\u27s equation. The set of equations is referred to as the electron fluid dynamical equations; and a successful solution therefor must meet a set of acceptable physical conditions at the trailing edge of the wave. For breakdown waves with a significant current behind the shock front, modifications must be made to the set of electron fluid dynamical equations, as well as the shock condition on electron temperature. Considering existence of current behind the shock front, we have derived the shock condition on electron temperature, and for a set of experimentally measured wave speeds, we have been able to find maximum current values for which solutions to our set of electron velocity, electron temperature, and electron number density within the dynamical transition region of the wave

Sharing data from clinical trials: the rationale for a controlled access approach.

The move towards increased transparency around clinical trials is welcome. Much focus has been on under-reporting of trials and access to individual patient data to allow independent verification of findings. There are many other good reasons for data sharing from clinical trials. We describe some key issues in data sharing, including the challenges of open access to data. These include issues in consent and disclosure; risks in identification, including self-identification; risks in distorting data to prevent self-identification; and risks in analysis. These risks have led us to develop a controlled access policy, which safeguards the rights of patients entered in our trials, guards the intellectual property rights of the original researchers who designed the trial and collected the data, provides a barrier against unnecessary duplication, and ensures that researchers have the necessary resources and skills to analyse the data

A cohort study of the associations between udder conformation, milk somatic cell count, and lamb weight in suckler ewes

A cohort study of 67 suckler ewes from 1 farm was carried out from January to May 2010 to investigate associations between udder conformation, udder half milk somatic cell count (SCC), and lamb weight. Ewes and lambs were observed at lambing. Ewe health and teat condition and lamb health and weight were recorded on 4 to 5 further occasions at 14-d intervals. At each observation, a milk sample was collected from each udder half for somatic cell counting. Two weeks after lambing, ewe udder conformation and teat placement were scored. Low lamb weight was associated with ewe SCC >400,000 cells/mL (−0.73kg), a new teat lesion 14 d previously (−0.91kg), suboptimal teat position (−1.38kg), rearing in a multiple litter (−1.45kg), presence of diarrhea at the examination (−1.19kg), and rearing by a 9-yr-old ewe compared with a 6-yr-old ewe (−2.36kg). High lamb weight was associated with increasing lamb age (0.21kg/d), increasing birth weight (1.65kg/kg at birth), and increasing number of days the ewe was given supplementary feed before lambing (0.06kg/d). High udder half SCC was associated with pendulous udders (9.6% increase in SCC/cm of drop) and greater total cross-sectional area of the teats (7.2% increase of SCC/cm2). Low SCC were associated with a heavier mean litter weight (6.7% decrease in SCC/kg). Linear, quadratic, and cubic terms for days in lactation were also significant. We conclude that poor udder and teat conformation are associated with high levels of intramammary infection, as indicated by increased SCC and that both physical attributes of the udder and SCC are linked to lamb growth, suggesting that selection of suckler ewes with better udder and teat conformation would reduce intramammary infection and increase lamb growth rate

Debris Disks in the Scorpius-Centaurus OB Association Resolved by ALMA

We present a CO(2-1) and 1240 um continuum survey of 23 debris disks with spectral types B9-G1, observed at an angular resolution of 0.5-1 arcsec with the Atacama Large Millimeter/Submillimeter Array (ALMA). The sample was selected for large infrared excess and age ~10 Myr, to characterize the prevalence of molecular gas emission in young debris disks. We identify three CO-rich debris disks, plus two additional tentative (3-sigma) CO detections. Twenty disks were detected in the continuum at the >3-sigma level. For the 12 disks in the sample that are spatially resolved by our observations, we perform an independent analysis of the interferometric continuum visibilities to constrain the basic dust disk geometry, as well as a simultaneous analysis of the visibilities and broad-band spectral energy distribution to constrain the characteristic grain size and disk mass. The gas-rich debris disks exhibit preferentially larger outer radii in their dust disks, and a higher prevalence of characteristic grain sizes smaller than the blowout size. The gas-rich disks do not exhibit preferentially larger dust masses, contrary to expectations for a scenario in which a higher cometary destruction rate would be expected to result in a larger mass of both CO and dust. The three debris disks in our sample with strong CO detections are all around A stars: the conditions in disks around intermediate-mass stars appear to be the most conducive to the survival or formation of CO.Comment: 16 pages, 6 figures, accepted for publication in Ap

Uncommon Applications of Deep Brain Stimulation in Hyperkinetic Movement Disorders

Background: In addition to the established indications of tremor and dystonia, deep brain stimulation (DBS) has been utilized less commonly for several hyperkinetic movement disorders, including medication-refractory myoclonus, ballism, chorea, and Gilles de la Tourette (GTS) and tardive syndromes. Given the lack of adequate controlled trials, it is difficult to translate published reports into clinical use. We summarize the literature, draw conclusions regarding efficacy when possible, and highlight concerns and areas for future study. Methods: A Pubmed search was performed for English-language articles between January 1980 and June 2014. Studies were selected if they focused primarily on DBS to treat the conditions of focus. Results: We identified 49 cases of DBS for myoclonus-dystonia, 21 for Huntington’s disease, 15 for choreacanthocytosis, 129 for GTS, and 73 for tardive syndromes. Bilateral globus pallidus interna (GPi) DBS was the most frequently utilized procedure for all conditions except GTS, in which medial thalamic DBS was more common. While the majority of cases demonstrate some improvement, there are also reports of no improvement or even worsening of symptoms in each condition. The few studies including functional or quality of life outcomes suggest benefit. A limited number of studies included blinded on/off testing. There have been two double-blind controlled trials performed in GTS and a single prospective double-blind, uncontrolled trial in tardive syndromes. Patient characteristics, surgical target, stimulation parameters, and duration of follow-up varied among studies. Discussion: Despite these extensive limitations, the literature overall supports the efficacy of DBS in these conditions, in particular GTS and tardive syndromes. For other conditions, the preliminary evidence from small studies is promising and encourages further study