6 research outputs found
Autoantibodies against type I IFNs in patients with life-threatening COVID-19
- Author
- Abad Capa Jorge
- Abel L.
- Abela L.
- Abelb L.
- Abelc L.
- Abers M.S.
- Agra J.J.C.
- Aguilera-Albesa S.
- Aiuti A.
- Akcan O.M.
- Al-Mulla F.
- Alarcon M.G.
- Alavoine L.
- Albert M.L.
- Alcover A.
- Aldave J.C.
- Algera A.G.
- Alkan G.
- Allardet-Servent J.
- Allende L.M.
- Alsina L.
- Alvarez J.T.
- Alyanakian M.A.
- Amador-Borrero B.
- Amat K.K.A.
- Amoura Z.
- Anderson M.S.
- Andrejak C.
- Angoulvant F.
- AntolĂ A.
- Arias A.A.
- Arias A.A.
- Arquero M.F.
- Arranz M.J.
- Arslan S.
- Aschard H.
- Assant S.
- Astrom K.
- Auguet T.
- Aytekin S.E.
- Azot A.
- Bachelet D.
- Bajolle F.
- Baldolli A.
- Ballester M.
- Bansal N.
- Barrett K.S.
- Barrou B.
- Basmaci R.
- Bastard P.
- Bax D.
- Behillil S.
- Behillil S.
- Bellani G.
- Belot A.
- Belota A.
- Beluze M.
- Benkerrou D.
- Bettini L.R.
- Beudel M.
- Beurton A.
- Bhavsar K.
- Bielicki J.
- Bigio B.
- Bilbao A.
- Bilguvar K.
- Biondi A.
- Bizien L.
- Blanch G.R.
- Blanchard-Rohner G.
- Blanco I.
- BlandiniĂšres A.
- Blazquez-Gamero D.
- Bloomfield M.
- Bogaard H.J.
- Bogunovic D.
- Boisson B.
- Boisson-Dupuis S.
- Bole-Feysot C.
- Bolivar-Prados Mireia
- Bolze A.
- Bolze A.
- Bomers M.
- Bompart F.
- Bondarenko A.
- Bonfanti P.
- Borie R.
- Bos Lieuwe D
- Bosticardo M.
- Botta M.
- Bouadma L.
- Boucherit S.
- Bouscambert M.
- Bousfiha A.A.
- Bousfiha A.A.
- Bousso P.
- Bouvattier C.
- Boyarchuk O.
- Bree G.
- Brodin P.
- Brodin P.
- Brouwer M.C.
- Bruhns P.
- Bruijning P.
- Bryceson Y.
- Bueno M.R.P.
- Bugiani M.
- Bulle E.
- Burbelo P.D.
- Burdet C.
- Bustamante C.D.
- Bustamante J.
- Bustamante J.
- Butte M.
- BĂ©ziat V.
- Calimli S.
- Capra R.
- Caralp M.
- Carrabba M.
- Casanova J.L.
- Casanovaa J.L.
- Casari G.
- Casasnovas C.
- Caseris M.
- Castagnoli R.
- Castelle M.
- Castelli F.
- Castro M.V.
- Catherinot E.
- Catherinot E.
- Caumes E.
- Cazzaniga M.
- Cervantes-Gonzalez M.
- Chair A.
- Chakravorty S.
- Chalumeau M.
- Charbit B.
- Charpentier C.
- Chauvin S.D.
- Chbihi M.
- Chen J.
- Cheng M.P.
- Chouchane O.
- Chrabieh M.
- Christodoulou J.
- Ciceri F.
- Cirulli E.
- Citerio G.
- Clavé P.
- Cloherty A.
- Clotet B.
- Cobat A.
- Codina A.
- Coelho A.
- Cohen J.I.
- Coignard B.
- Colkesen F.
- ColobrĂĄn Oriol Roger
- Comarmond C.
- Condino-Neto A.
- Contro E.
- Cooper M.A.
- Corsico A.G.
- Costa Y.
- Couffignal C.
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- Cuadros E.N.
- Cumano A.
- D'ortenzio E.
- da Silveira C.
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- Duval X.
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- Eberl G.
- Ecobichon J.L.
- Elbers P.
- Eldars W.
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- Gregersen P.K.
- Grobusch M.P.
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- Gut M.
- Hadjadj J.
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- Hagin D.
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- Hamann J.
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- Hammarström Q.P.
- Harris V.
- Hasan M.
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- Heath J.
- Hemke R.
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- Hoffmann H.H.
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- Holland S.M.
- Hollmann M.W.
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- Horn J.
- Houhou N.
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- Hsieh E.
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- Husebye E.S.
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- Ilovich A.S.
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- Jamme M.
- Joost Wiersinga W.
- Jordan I.
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- KrĂłl Z.J.
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- Kwan Y.W.M.
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- Lampasona V.
- Lantz O.
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- Lau Y.L.
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- Le Bourgeois F.
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- Le Pen J.
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- Li Z.
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- Liu D.
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- Lorenzo-Salazar J.M.
- Louapre C.
- Lubetzki C.
- Lucas C.L.
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- Lye D.C.
- Lyonnet S.
- LĂ©vy R.
- LĂ©vy Y.
- Malvy D.
- Malvy D.
- Mambert M.
- Manchon P.
- Mandic M.
- Maniatis T.
- Manry J.
- Mansouri D.
- Mansouri D.
- Marjani M.
- Marodi L.
- Marseglia G.L.
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- Martinez A.M.
- Martinez-Picado J.
- Martinez-Picado J.
- Marzana I.
- Masson C.
- Mathian A.
- Matos L.R.B.
- Matthews G.V.
- Mayaux J.
- Mayaux J.
- Medina Y.N.
- Meghadecha M.
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- Melki I.
- Mentré F.
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- Tandjaoui-Lambiottea Y.
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- Terrier B.
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- Turvey S.
- Téoulé F.
- Uddin F.
- Uddin M.J.
- Ungeheuer M.N.
- Universitat AutĂČnoma de Barcelona
- Ursini M.V.
- Ursini M.V.
- Uzunhan Y.
- Vabres P.
- Valencia-Ramos J.
- Valsecchi M.G.
- van Agtmael M.
- van Baarle F.
- van de Beek D.
- van de Beek D.
- van de Beek D.
- van Den Rym A.M.
- van der Poll T.
- van der Valk M.
- van der Werf S.
- van der Werf S.
- van Mourik N.
- van Vugt M.
- Vandernoot I.
- Vanel N.
- Vasse M.
- Vatansev H.
- Vazquez S.E.
- Veelo D.
- Veislinger A.
- Viel S.
- Vignali V.
- Vilain C.
- Vilaire M.E.
- Vincent A.
- Vinh D.C.
- Vinh D.C.
- Visseaux B.
- Visseaux B.
- Vlaar A.P.J.
- Vladikine N.
- Vogt G.
- Voiriot G.
- von Bernuth H.
- Vuotto F.
- VĂ©lez-Santamaria V.
- Wang Q.
- Washington N.
- Wiedemann A.
- Woollett M.
- Wouters D.
- Yang R.
- Yasar K.K.
- Yazdanpanah Y.
- Yazdanpanah Y.
- Yosunkaya A.
- Young B.E.
- Yucel F.
- Zannad F.
- Zarhrate M.
- Zatz M.
- Zawadzki P.
- Zhang P.
- Zhang Q.
- Zhang S.Y.
- Zhang Y.
- Zwinderman A.H.
- Ăñigo-Campos A.
- Publication venue
- 'American Association for the Advancement of Science (AAAS)'
- Publication date
- 01/01/2020
- Field of study
Interindividual clinical variability in the course of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is vast. We report that at least 101 of 987 patients with life-threatening coronavirus disease 2019 (COVID-19) pneumonia had neutralizing immunoglobulin G (IgG) autoantibodies (auto-Abs) against interferon-w (IFN-w) (13 patients), against the 13 types of IFN-a (36), or against both (52) at the onset of critical disease; a few also had auto-Abs against the other three type I IFNs. The auto-Abs neutralize the ability of the corresponding type I IFNs to block SARS-CoV-2 infection in vitro. These auto-Abs were not found in 663 individuals with asymptomatic or mild SARS-CoV-2 infection and were present in only 4 of 1227 healthy individuals. Patients with auto-Abs were aged 25 to 87 years and 95 of the 101 were men. A B cell autoimmune phenocopy of inborn errors of type I IFN immunity accounts for life-threatening COVID-19 pneumonia in at least 2.6% of women and 12.5% of men
Katamnestische Untersuchungen nach Pertussis-Encephalose
- Author
- A. Breton
- A. Busemann
- A. Herrlich
- A.-L. Annell
- B. Walthard
- Binetarium
- C. Dreyfus-Brisac
- Ch. BĂŒhler
- Chr. Kunze
- D. Abels
- D. Pospischill
- E. Wartegg
- F. A. Gibbs
- F. A. Gibbs
- F. Hansen
- F. Puntigam
- G. B. Cavazzuti
- G. Bardosova
- G. Bosch
- G. Göllnitz
- G. Staabs von
- H. Asperger
- H. Asperger
- H. Berger
- H. Bussow
- H. Doose
- H. G. Arlt
- H. Hubach
- H. Jacob
- H. Pette
- H. Wallis
- H. Zulliger
- J. C. Raven
- J. KĂŒlz
- J. Pietsch
- J. Radermecker
- J. Radermecker
- K. Jaspers
- K.-H. Wewetzer
- L. Bogaert van
- L. Hohman
- M. A. LĂ©vy-Alcover
- M. Spragins
- M. Tramer
- Ph. Bamberger
- R. Degen
- R. Garsche
- R. Garsche
- R. Garsche
- R. Garsche
- R. Garsche
- R. Schiffter
- S. Levin
- T. Nishimura
- V. Holub
- W. Raue
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/1965
- Field of study
Autoantibodies against type I IFNs in patients with life-threatening COVID-19
- Author
- Abad Capa Jorge
- Abel Laurent
- Abela L.
- Abelb L.
- Abelc L.
- Abers M. S.
- Agra J. J. C.
- Aguilera-Albesa Sergio
- Aiuti A.
- Akcan O. M.
- Al-Mulla F.
- Alarcon M. G.
- Alavoine L.
- Albert Matthew L
- Alcover A.
- Aldave J. C.
- Algera A. G.
- Alkan G.
- Allardet-Servent J.
- Allende L. M.
- Alsina L.
- Alyanakian M. A.
- Amador-Borrero B.
- Amat K. K. A.
- Amoura Z.
- Anderson M. S.
- Andrejak C.
- Angoulvant F.
- AntolĂ Arnau
- Arias A. A.
- Arias A. A.
- Arquero M. F.
- Arranz M. J.
- Arslan S.
- Aschard H.
- Assant S.
- Astrom K.
- Auguet T.
- Aytekin S. E.
- Azot A.
- Bachelet Delphine
- Bajolle F.
- Baldolli A.
- Ballester Devis Maria
- Bansal N.
- Barrett K. S.
- Barrou B.
- Basmaci R.
- Bastard Paul
- Bax D.
- Behillil S.
- Behillil S.
- Bellani G.
- Belot Alexandre
- Belota A.
- Beluze M.
- Benkerrou D.
- Bettini L. R.
- Beudel M.
- Beurton A.
- Bhavsar K.
- Bielicki J.
- Bigio B.
- Bilbao A.
- Bilguvar K.
- Biondi A.
- Bizien L.
- Blanch G. R.
- Blanchard-Rohner G.
- Blanco Guillermo Ignacio
- BlandiniĂšres A.
- Bloomfield M.
- BlĂĄzquez-Gamero Daniel
- Bogaard H. J.
- Bogunovic Dusan
- Boisson Bertrand
- Boisson-Dupuis S.
- Bole-Feysot C.
- Bolivar-Prados Mireia
- Bolze A.
- Bolze A.
- Bomers M.
- Bompart F.
- Bondarenko A.
- Bonfanti Paolo
- Borie R.
- Bos Lieuwe D..
- Bosticardo M.
- Botta Michela
- Bouadma L.
- Boucherit S.
- Bouscambert M.
- Bousfiha A. A.
- Bousfiha A. A.
- Bousso P.
- Bouvattier C.
- Boyarchuk O.
- Bree G.
- Brodin P.
- Brodin P.
- Brouwer M. C.
- Bruhns P.
- Bruijning P.
- Bryceson Y.
- Bueno M. R. P.
- Bugiani Marianna
- Bulle E.
- Burbelo P. D.
- Burdet C.
- Bustamante C. D.
- Bustamante J.
- Bustamante J.
- Butte M.
- BĂ©ziat V.
- Calimli S.
- Capra R.
- Caralp M.
- Carrabba M.
- Casanova Jean-Laurent
- Casanovaa J. L.
- Casari G.
- Casasnovas Carlos
- Caseris M.
- Castagnoli R.
- Castelle M.
- Castelli F.
- Castro M. V.
- Catherinot E.
- Catherinot E.
- Caumes E.
- Cazzaniga M.
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- Publication venue
- 'American Association for the Advancement of Science (AAAS)'
- Publication date
- 01/01/2020
- Field of study
International audienceInterindividual clinical variability in the course of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is vast. We report that at least 101 of 987 patients with life-threatening coronavirus disease 2019 (COVID-19) pneumonia had neutralizing immunoglobulin G (IgG) autoantibodies (auto-Abs) against interferon-Ï (IFN-Ï) (13 patients), against the 13 types of IFN-α (36), or against both (52) at the onset of critical disease; a few also had auto-Abs against the other three type I IFNs. The auto-Abs neutralize the ability of the corresponding type I IFNs to block SARS-CoV-2 infection in vitro. These auto-Abs were not found in 663 individuals with asymptomatic or mild SARS-CoV-2 infection and were present in only 4 of 1227 healthy individuals. Patients with auto-Abs were aged 25 to 87 years and 95 of the 101 were men. A B cell autoimmune phenocopy of inborn errors of type I IFN immunity accounts for life-threatening COVID-19 pneumonia in at least 2.6% of women and 12.5% of men
The risk of COVID-19 death is much greater and age dependent with type I IFN autoantibodies
- Author
- Abad Jorge
- Abel Laurent
- Abel Laurent
- Abel Laurent
- Abel Laurent
- Accordino Giulia
- Achille Cristian
- Acosta-Ampudia Yeny
- Agra Juan José Cåceres
- Aguilera-Albesa Sergio
- AguilĂł-Cucurull Aina
- Aiuti Alessandro
- Aiuti Alessandro
- Aiuti Alessandro
- Akcan Ăzge Metin
- Al-Muhsen Saleh
- Al-Mulla Fahd
- Alavoine Loubna
- Albert Matthew
- Albisures Jonathan Antonio Roblero
- Alcover Andres
- Aldave Juan
- Algera Anne Geke
- Aliberti Anna
- Alkan Gulsum
- Alkhater Suzan
- Alkhater Suzan
- Allardet-Servent Jerome
- Allavena Clotilde
- Allende Luis
- Alonso-Arias Rebeca
- Alshahrani Mohammed
- Alsina Laia
- Alvarez Josep Trenado
- Alyanakian Marie-Alexandra
- Amador-Borrero Blanca
- Amat Karine
- Amoura Zahir
- Anaya Juan-Manuel
- Anderson Mark
- Anderson Mark
- Andreakos Evangelos
- Andreakos Evangelos
- Andrejak Claire
- Andrés Ana De
- Anglicheau Dany
- Angoulvant François
- Annereau Jean-Philippe
- AntolĂ Arnau
- Appelman Brent
- Arias Andrés
- Arias Andrés Augusto
- Arkin Lisa
- Arquero Miguel Fernandez
- Arranz MarĂa JesĂșs
- Arrestier Romain
- Arrestier Romain
- Asano Takaki
- Aschard Hugues
- Aubart MĂ©lodie
- Auguet Teresa
- Avramenko Iryna
- Aytekin Gökhan
- Aytekin Selma Erol
- Azot Axelle
- Azoulay Cecile
- Bachelet Delphine
- Bahram Seiamak
- Bajolle Fanny
- Baldanti Fausto
- Baldolli Aurélie
- Ballester Maite
- Baris-Feldman Hagit
- Barreiros Lucila
- Barrou Benoit
- Bartoli Marie
- Barzaghi Federica
- Basmaci Romain
- Basso Sabrina
- Bastard Paul
- Batten Isabella
- Bauters Fré
- Bax Diane
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- Behillill Sylvie
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- Bondarenko Anastasiia
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- Su Helen
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- SĂĄnchez-RamĂłn Silvia
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- SĂžrensen Erik
- Taccone Fabio
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- Tanaka Junko
- Tancevski Ivan
- Tancevski Ivan
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- Tandjaoui-Lambiotte Yacine
- Tangy Frédéric
- Tangye Stuart
- Tangye Stuart
- Tardivon Coralie
- Tardy Bernard
- Taupin Jean-Luc
- Tavernier Simon
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- Terrier Benjamin
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- Teunissen Charlotte
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- Trouillet-Assant Sophie
- Troya JesĂșs
- Troya JesĂșs
- Tsang Owen
- Tserel Liina
- Tso Eugene
- Tsonas Anissa
- Tsumura Miyuki
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- Tubiana Sarah
- Tubiana Sarah
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- Tzourio Christophe
- Téoulé François
- Uddin K.
- Uddin Mohammed
- Ungeheuer Marie-Noëlle
- Ursini Matilde Valeria
- Utsumi Takanori
- Uzunhan Yurdagul
- Vabres Pierre
- Valencia-Ramos Juan
- Valsecchi Maria Grazia
- van Agtmael Michiel
- van Baarle Frank
- van Braeckel Eva
- van de Beek Diederik
- van de Beek Diederik
- van de Beek Diederik
- van den Rym Ana Maria
- van der Poll Tom
- van der Valk Marc
- van der Werf Sylvie
- van der Werf Sylvie
- van Mourik Niels
- van Praet Jens
- van Vugt MichĂšle
- Vanderlinden Dimitri
- Vandernoot Isabelle
- Vanel Noémie
- Vasse Marc
- Veelo Denise
- Veislinger Aurélie
- Velez-Santamaria Valentina
- Veliz Silvia Patricia Zuniga
- Venet Fabienne
- Vergara José Alejandro Daza
- Vidaur Loreto
- Vidaur Loreto
- Vidigal Mateus
- Vidigal Mateus
- Viel SĂ©bastien
- Vignali Valérie
- Vilaire-Meunier Marie
- Villain CĂ©dric
- Villar-GarcĂa Judit
- Vincent Audrey
- Vinh Donald
- Vinh Donald
- Visseaux Benoit
- Visseaux Benoit
- Vlaar Alexander
- Vogt Guillaume
- Voiriot Guillaume
- Volleman Carolien
- Volokha Alla
- von Bernuth Horst
- von Stemann Jakob Hjorth
- Vught Lonneke
- Vuotto Fanny
- VĂ©lez VerĂłnica Posada
- Waucquier Nawal
- Wauters Els
- Wauters Joost
- Wauters Joost
- Wauters Joost
- Wiedemann Aurélie
- Wiersinga W. Joost
- Wouters Dorien
- Wu Alan
- Wu Tak-Chiu
- YahĆi Aysun
- Yang Rui
- Yasar Kadriye Kart
- Yazdanpanah Yazdan
- Yazdanpanah Yazdan
- Yepes Jairo David Torres
- Yesilbas Osman
- Yildiz Mehmet
- Young Barnaby
- YĂŒkselmiĆ Ufuk
- Zatz Mayana
- Zatz Mayana
- Zatz Mayana
- Zawadzki Pawel
- Zhang Peng
- Zhang Qian
- Zhang Shen-Ying
- Zhang Yu
- Zimmer Christophe
- Zins Marie
- Zins Marie
- Zuccaro Valentina
- Zwinderman A.
- Ăñigo-Campos Antonio
- Ăz Ćadiye KĂŒbra TĂŒter
- Ăzkan Esra AkyĂŒz
- Ăzçelik Tayfun
- Publication venue
- 'Proceedings of the National Academy of Sciences'
- Publication date
- 24/05/2022
- Field of study
International audienceSignificance There is growing evidence that preexisting autoantibodies neutralizing type I interferons (IFNs) are strong determinants of life-threatening COVID-19 pneumonia. It is important to estimate their quantitative impact on COVID-19 mortality upon SARS-CoV-2 infection, by age and sex, as both the prevalence of these autoantibodies and the risk of COVID-19 death increase with age and are higher in men. Using an unvaccinated sample of 1,261 deceased patients and 34,159 individuals from the general population, we found that autoantibodies against type I IFNs strongly increased the SARS-CoV-2 infection fatality rate at all ages, in both men and women. Autoantibodies against type I IFNs are strong and common predictors of life-threatening COVID-19. Testing for these autoantibodies should be considered in the general population
The risk of COVID-19 death is much greater and age dependent with type I IFN autoantibodies
- Author
- Abad Jorge
- Abel Laurent
- Abel Laurent
- Abel Laurent
- Abel Laurent
- Accordino Giulia
- Achille Cristian
- Acosta-Ampudia Yeny
- Agra Juan José Cåceres
- Aguilera-Albesa Sergio
- AguilĂł-Cucurull Aina
- Aiuti Alessandro
- Aiuti Alessandro
- Aiuti Alessandro
- Akcan Ăzge Metin
- Al-Muhsen Saleh
- Al-Mulla Fahd
- Alavoine Loubna
- Albert Matthew
- Albisures Jonathan Antonio Roblero
- Alcover Andres
- Aldave Juan
- Algera Anne Geke
- Aliberti Anna
- Alkan Gulsum
- Alkhater Suzan
- Alkhater Suzan
- Allardet-Servent Jerome
- Allavena Clotilde
- Allende Luis
- Alonso-Arias Rebeca
- Alshahrani Mohammed
- Alsina Laia
- Alvarez Josep Trenado
- Alyanakian Marie-Alexandra
- Amador-Borrero Blanca
- Amat Karine
- Amoura Zahir
- Anaya Juan-Manuel
- Anderson Mark
- Anderson Mark
- Andreakos Evangelos
- Andreakos Evangelos
- Andrejak Claire
- Andrés Ana De
- Anglicheau Dany
- Angoulvant François
- Annereau Jean-Philippe
- AntolĂ Arnau
- Appelman Brent
- Arias Andrés
- Arias Andrés Augusto
- Arkin Lisa
- Arquero Miguel Fernandez
- Arranz MarĂa JesĂșs
- Arrestier Romain
- Arrestier Romain
- Asano Takaki
- Aschard Hugues
- Aubart MĂ©lodie
- Auguet Teresa
- Avramenko Iryna
- Aytekin Gökhan
- Aytekin Selma Erol
- Azot Axelle
- Azoulay Cecile
- Bachelet Delphine
- Bahram Seiamak
- Bajolle Fanny
- Baldanti Fausto
- Baldolli Aurélie
- Ballester Maite
- Baris-Feldman Hagit
- Barreiros Lucila
- Barrou Benoit
- Bartoli Marie
- Barzaghi Federica
- Basmaci Romain
- Basso Sabrina
- Bastard Paul
- Batten Isabella
- Bauters Fré
- Bax Diane
- Bayhan Gulsum Iclal
- Behillil Sylvie
- Behillill Sylvie
- Bellani Giacomo
- Belot Alexandre
- Belot Alexandre
- Belot Alexandre
- Beluze Marine
- Benech Nicolas
- Benkerrou Dehbia
- Beretta Ilaria
- Bergin Colm
- Bertholon Frédérique
- Bettini Laura Rachele
- Beudel Martijn
- Bezrodnik Liliana
- Bhavsar Krishna
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- Sediva Anna
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- Seminario Analia Gisela
- Sene Damien
- Sene Damien
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- SeppÀnen Mikko
- SeppÀnen Mikko R.J.
- Shahrooei Mohammad
- Shahrooei Mohammed
- Sharif-Askari Fatemeh Saheb
- Shaw Elana
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- Sottini Alessandra
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- Stilma Willemke
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- Su Helen
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- Taccone Fabio
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- Tancevski Ivan
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- Tsang Owen
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- Tso Eugene
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- Tsumura Miyuki
- Tual Christelle
- Tubiana Sarah
- Tubiana Sarah
- Tucci Alessandra
- Tuinman Pieter
- Turvey Stuart
- Tzourio Christophe
- Téoulé François
- Uddin K.
- Uddin Mohammed
- Ungeheuer Marie-Noëlle
- Ursini Matilde Valeria
- Utsumi Takanori
- Uzunhan Yurdagul
- Vabres Pierre
- Valencia-Ramos Juan
- Valsecchi Maria Grazia
- van Agtmael Michiel
- van Baarle Frank
- van Braeckel Eva
- van de Beek Diederik
- van de Beek Diederik
- van de Beek Diederik
- van den Rym Ana Maria
- van der Poll Tom
- van der Valk Marc
- van der Werf Sylvie
- van der Werf Sylvie
- van Mourik Niels
- van Praet Jens
- van Vugt MichĂšle
- Vanderlinden Dimitri
- Vandernoot Isabelle
- Vanel Noémie
- Vasse Marc
- Veelo Denise
- Veislinger Aurélie
- Velez-Santamaria Valentina
- Veliz Silvia Patricia Zuniga
- Venet Fabienne
- Vergara José Alejandro Daza
- Vidaur Loreto
- Vidaur Loreto
- Vidigal Mateus
- Vidigal Mateus
- Viel SĂ©bastien
- Vignali Valérie
- Vilaire-Meunier Marie
- Villain CĂ©dric
- Villar-GarcĂa Judit
- Vincent Audrey
- Vinh Donald
- Vinh Donald
- Visseaux Benoit
- Visseaux Benoit
- Vlaar Alexander
- Vogt Guillaume
- Voiriot Guillaume
- Volleman Carolien
- Volokha Alla
- von Bernuth Horst
- von Stemann Jakob Hjorth
- Vught Lonneke
- Vuotto Fanny
- VĂ©lez VerĂłnica Posada
- Waucquier Nawal
- Wauters Els
- Wauters Joost
- Wauters Joost
- Wauters Joost
- Wiedemann Aurélie
- Wiersinga W. Joost
- Wouters Dorien
- Wu Alan
- Wu Tak-Chiu
- YahĆi Aysun
- Yang Rui
- Yasar Kadriye Kart
- Yazdanpanah Yazdan
- Yazdanpanah Yazdan
- Yepes Jairo David Torres
- Yesilbas Osman
- Yildiz Mehmet
- Young Barnaby
- YĂŒkselmiĆ Ufuk
- Zatz Mayana
- Zatz Mayana
- Zatz Mayana
- Zawadzki Pawel
- Zhang Peng
- Zhang Qian
- Zhang Shen-Ying
- Zhang Yu
- Zimmer Christophe
- Zins Marie
- Zins Marie
- Zuccaro Valentina
- Zwinderman A.
- Ăñigo-Campos Antonio
- Ăz Ćadiye KĂŒbra TĂŒter
- Ăzkan Esra AkyĂŒz
- Ăzçelik Tayfun
- Publication venue
- 'Proceedings of the National Academy of Sciences'
- Publication date
- 24/05/2022
- Field of study
International audienceSignificance There is growing evidence that preexisting autoantibodies neutralizing type I interferons (IFNs) are strong determinants of life-threatening COVID-19 pneumonia. It is important to estimate their quantitative impact on COVID-19 mortality upon SARS-CoV-2 infection, by age and sex, as both the prevalence of these autoantibodies and the risk of COVID-19 death increase with age and are higher in men. Using an unvaccinated sample of 1,261 deceased patients and 34,159 individuals from the general population, we found that autoantibodies against type I IFNs strongly increased the SARS-CoV-2 infection fatality rate at all ages, in both men and women. Autoantibodies against type I IFNs are strong and common predictors of life-threatening COVID-19. Testing for these autoantibodies should be considered in the general population