Photoproduction evidence for and against hidden-strangeness states near 2 GeV

Experimental evidence from coherent diffractive proton scattering has been reported for two narrow baryonic resonances which decay predominantly to strange particles. These states, with masses close to 2.0 GeV would, if confirmed, be candidates for hidden strangeness states with unusual internal structure. In this paper we examine the literature on strangeness photoproduction, to seek additional evidence for or against these states. We find that one state is not confirmed, while for the other state there is some mild supporting evidence favoring its existence. New experiments are called for, and the expected photoproduction lineshapes are calculated.Comment: 9 pages, RevTex, five postscript figures, submitted to PR

Relationship between IL1B gene polymorphism and smoking with the risk of myocardial infarction

Genotype and smoking determined risks of myocardial infarction in patients with ischemic heart disease. Homozygous genotype C (rs16944) of IL1B is associated with myocardial infarction (OR = 3,17 (95% Cl = 0,92-10,89); р < 0,01) and heterozygous carrier state of this allelic gene doesn't increase risks (OR = 1,36 (95% CI = 0,83-2,2); р = 0,01). Smoking 5 times increases risk of myocardial infarction (OR = 5,16 (95% CI = 1,05-25,39); p < 0,05) in homozygotes, and 1,5 times (OR = 1,46 (95% CI = 0,77-2,78); p < 0,05) - in heterozygotes of 511Т/С lL1B. Haplotype СТ (rs1143634 - rs16944) of IL1B is connected with the decrease of risk of myocardial infarction in nonsmoking patients (OR = 0,43 (95% DI = 0,19-0,95); р < 0,01)

Scintillating properties of frozen new liquid scintillators

The light emission from scintillators which are liquid at room temperature was studied in the interval between $+20$~$^{\circ}$C and $-120$~$^{\circ}$C, where the phase transition from liquid to solid takes place. The light yield measured at $-120$~$^{\circ}$C is about twice as much as that observed at $+20$~$^{\circ}$C. By cooling the scintillator from $+20$~$^{\circ}$C to $-120$~$^{\circ}$C and then heating it from $-120$~$^{\circ}$C to $+20$~$^{\circ}$C, the light yield varies in steps at well defined temperatures, which are different for the cooling and heating processes. These hysteresis phenomena appear to be related to the solvent rather than to the dopant. The decay time of scintillation light was measured at $+20$~$^{\circ}$C and $-120$~$^{\circ}$C. Whilst at room temperature most of the light is emitted with a decay time of 6--8 ns, at $-120$~$^{\circ}$C a slower component, with a decay time of 25--35 ns, becomes important

Charm production nearby threshold in pA-interactions at 70 GeV

The results of the SERP-E-184 experiment at the U-70 accelerator (IHEP, Protvino) are presented. Interactions of the 70 GeV proton beam with C, Si and Pb targets were studied to detect decays of charmed $D^0$, $\overline D^0$, $D^+$, $D^-$ mesons and $\Lambda _c^+$ baryon near their production threshold. Measurements of lifetimes and masses are shown a good agreement with PDG data. The inclusive cross sections of charm production and their A-dependencies were obtained. The yields of these particles are compared with the theoretical predictions and the data of other experiments. The measured cross section of the total open charm production ($\sigma _{\mathrm {tot}}(c\overline c)$ = 7.1 $\pm$ 2.3(stat) $\pm$1.4(syst) $\mu$b/nucleon) at the collision c.m. energy $\sqrt {s}$ = 11.8 GeV is well above the QCD model predictions. The contributions of different species of charmed particles to the total cross section of the open charm production in proton-nucleus interactions vary with energy.Comment: 4 pages, 6 pages, 38th International Conference on High Energy Physics 3-10 August 2016, Chicago, US

Organ-specific LPS-induced inflammatory gene expression in adult Zebrafish

Systemic inflammation is known to be a key component of infection and non-infection diseases progression and may lead to multiorgan failure, persistent inflammation, immunosuppression, catabolism syndrome or even indolent death. This importance dictates the need for relevant in vivo models of inflammation to investigate the pathogenesis of numerous diseases and to perform drug screening. Danio rerio (zebrafish) became one of the most important models to explore biological processes in vivo. The aim of the study was to generate a lipopolysaccharide (LPS) model of systemic inflammation in vivo using zebrafish and to identify organspecific proinflammatory genes activity after intraperitoneal LPS infusion. We performed organ specific analysis of main proinflammatory genes expression in zebrafish after LPS stimulation. Comparing 18s, eef1a1l1, gapdh, and actb as potential housekeeping genes, we came to conclusion that eef1a1l1 with 99% effectiveness is the most promising for further normalization in this model. The genes activity was the most pronounced in the heart where the expression of IL6, CXCL8a, and CXCL18β was increased up to 100-fold. Moreover, the kidneys were the most involved in the inflammatory process since the highest number of analysed genes were up-regulated there: expression levels of CXCL18β, CXCL8a, IL1β, IL6, Mpeg1.2, and TNFa were significantly increased. This was probably related to the kidney activity as an immune and hematopoietic organ. The lowest reactivity was detected in the muscles. Immune reactions could be dose-dependent, for instance the infusion of 20 µg LPS led to decrease of expression of IFNy, Mpeg 1.2, and Mpeg 1.1 in the liver and to increase of Mpeg 1.2 expression in the kidney comparing with 10 µg dosage. Thus, due to the high degree of the similarity and other unique properties, Danio rerio has the advantage of being relevant model of inflammation. Our model demonstrated that the investigation of isolated zebrafish organs could be useful and informative for the investigation of inflammatory processes

ASSOCIATION OF TREM-1 GENE POLYMORPHISMS WITH INFECTIVE ENDOCARDITIS

Infective endocarditis (IE) is a septic inflammation of endocardium, which generally involves the lining of the heart chambers and heart valves. The development of IE depends in many respects on how properly and efficiently the immune system responds to the occurrence of an infection. Innate immunity, which carries out the response to a transient bacteremia, is genetically determined in a large extent. Pattern recognition receptors, which identify pathogenand danger-associated molecular patterns, are the main effectors of innate immune response; one of these receptors is triggering receptor expressed on myeloid cells-1 (TREM-1). We hypothesized that inherited variation in TREM-1 gene may affect individual susceptibility to IE. The distribution of genotypes and alleles of rs1817537, rs3804277, rs6910730, rs7768162, rs2234246, rs4711668, rs9471535, and rs2234237 gene polymorphisms was investigated in 110 Caucasian (Russian) subjects with IE and 300 age-, sex-, and ethnicity-matched healthy blood donors. Odds ratios with 95% confidence intervals were calculated. We found that rs1817537 polymorphism was associated with decreased IE risk (OR = 0.60; 95%CI = 0.37–0.99; р = 0.046, dominant model); however, this was not significant after an adjustment for multiple comparisons. Therefore, we observed no statistically significant association between the investigated polymorphisms within TREM-1 gene and IE. Further in-depth investigations in this field are necessary to shed the light on the impact of inherited variation within innate immune response genes on the development of IE