Overtourism: A literature review to assess implications and future perspectives

Overtourism is an emerging concept facing the world's main tourist destinations. The growth that tourism has undergone in recent decades is of two different types. On the one hand, the development of new technologies and the creation of low-cost airline carriers have increased tourism levels, leading to growth even in emerging economies. On the other hand, uncontrolled demand alongside a concentration of tourism in particular destinations impact negatively both territories and local communities. The problems caused in some destinations by the increasing, ongoing growth in tourism have created the issue of "overtourism," which is assuming an increasing significance in the literature. This paper contributes to the literature by providing an exploratory study with which to better understand the origins of overtourism, its implications, and predicted future perspectives in respect to the issue. Examination of the new evidence presented here contributes to the expanding knowledge of particular problems of tourism development

3D FEM and DEM Analyses of Underground Openings in Competent Rock Masses

The paper is aimed at comparing the results of numerical analyses of underground openings in competent rock masses like the Carrara Marble (Italy) by considering a real and well documented case study. More specifically, 3D FEM and DEM analyses were carried out on a rock-mass model interested by two faults and three sets of discontinuities. The geometrical model is representative of deep underground openings where spalling-cracks and rock bursts can occur. PLAXIS 3D and 3DEC were used for the analyses. Intact rock and rock mass characterization of Carrara Marble was inferred from available technical literature. The analysis results were compared in terms of principal stresses and displacements in a number of monitoring points around the opening. The main practical interest is to find out a reliable approach for evaluating the stability of very large openings in a competent rock mass like Carrara marble. For such a purpose, a number of available in-situ stress measurements were used

Intermittency in the large N-limit of a spherical shell model for turbulence

A spherical shell model for turbulence, obtained by coupling $N$ replicas of the Gledzer, Okhitani and Yamada shell model, is considered. Conservation of energy and of an helicity-like invariant is imposed in the inviscid limit. In the $N \to \infty$ limit this model is analytically soluble and is remarkably similar to the random coupling model version of shell dynamics. We have studied numerically the convergence of the scaling exponents toward the value predicted by Kolmogorov theory (K41). We have found that the rate of convergence to the K41 solution is linear in 1/N. The restoring of Kolmogorov law has been related to the behaviour of the probability distribution functions of the instantaneous scaling exponent.Comment: 10 pages, Latex, 3 Postscript figures, to be published on Europhys. Let

Esthesioneuroblastoma is not a member of the primitive peripheral neuroectodermal tumour-Ewing’s group

Esthesioneuroblastoma (ENB) is a rare, site-specific, locally aggressive neuronal malignancy so far thought to belong to primitive peripheral neuroectodermal tumour-Ewing's tumour (pPNETs-ETs). Its anatomical location, in addition to morphologic, immunophenotypic and ultrastructural features, suggests its origin in the neuronal or neuroendocrine cells of the olfactory epithelium. However, the cytogenetic and molecular data currently available appear controversial on the presence of the typical translocation t(11;22)(q24;q12) and of trisomy 8, chromosomal changes that characterize the tumours belonging to the pPNETs-ETs. Herein we have analysed five ENB tumour specimens for trisomy 8 by fluorescence in situ hybridization (FISH), for the presence of EWS gene rearrangements by FISH, reverse transcription polymerase chain reaction and Southern blot analyses, as well as for the expression of the Ewing sarcoma-associated MIC2 antigen by immunohistochemistry. Neither EWS/FLI-I, EWS/ERG and EWS/FEV fusion genes nor MIC2 expression were found in any tumour, whereas trisomy 8 was found in one case only. Moreover, DNA from three cases analysed by Southern blot did not show EWS gene rearrangements. Our results support the evidence that ENB is not a member of the pPNETs-ETs. © 1999 Cancer Research Campaig

IGFBP7: an oncosuppressor gene in thyroid carcinogenesis

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A novel two-stage kinetic model for surface DBD simulations in air

In this work, a novel 0D model for the evaluation of O-3 and NO2 produced by a surface dielectric barrier discharge (SDBD) in a closed environment is presented. The model is composed by two coupled sub-models, a discharge sub-model and an afterglow one. The first one, simulating the discharge regime and consequently including electron impact reactions, aims to calculate the production rates of a set of key species (atomic oxygen, excited states of molecular oxygen and molecular nitrogen). These latter are the input of the afterglow sub-model, that simulates the afterglow regime. We introduce a methodology to relate the production rates of the above mentioned species to the input power of the SDBD reactor. The simulation results are validated by a comparison with experimental data from absorption spectroscopy. The experimental measurements are carried out as follows. First, the discharge is turned on until the NO2 number density reaches steady state. Then, the discharge is turned off for several minutes. Finally, the discharge is turned on again to observe the effects of the NO2 concentration on ozone dynamics. The entire process is done without opening the box. The system operating in all the above-listed conditions is simulated for three different levels of input power

Cytogenetic study in therapy-related myelodysplastic syndromes (t-MDS) and acute non-lymphocytic leukaemia (t-ANLL).

A cytogenetic study was performed in 27 patients suspected of t-MDS or t-ANLL. In 12 patients the diagnosis of t-MDS or t-ANLL was confirmed by morphological, cytochemical and immunophenotypical analysis. The cases were classified as RA (one), RAEB (four), CMML (two), ANLL (five). They had received chemotherapy and/or RT for Hodgkin's disease (eight cases), solid tumours (three cases) and multiple myeloma (one case). Clonal chromosome abnormalities were found in bone marrow or peripheral blood cells in all the 12 cases. Five patients had a clonal abnormality of chromosome no. 5 (monosomy, deletions, translocation and inversion of 5q). The critical region on chromosome no. 5 comprised bands q12-q34. Monosomy and deletion of chromosome 7q was observed in the other two patients. In the six remaining patients various karyotypic patterns were observed including a t(4;11) (q21;q23) in one case, monosomies (four cases) and trisomies (one case) of different chromosomes. In the other 15 cases, the presence of a normal karyotype together with the morphological and immunophenotypical characterisation was consistent with a diagnosis of non-neoplastic specimens

Identification of a novel spliced variant of the SYT gene expressed in normal tissues and in synovial sarcoma

Synovial sarcoma (SS) is cytogenetically characterized by the translocation t(X;18)(p11.2-q11.2) generating a fusion between the SYT gene on chromosome 18 and one member of the SSX family gene (SSX1; SSX2; SSX4) on chromosome X. Here, we report for the first time that 2 forms of SYT mRNA are present in both normal tissues and SSs. By amplifying the full-length SYT cDNA of two SSs, we detected 2 bands, here designated N-SYT and I-SYT. The latter, previously undescribed, contains an in-frame insertion of 93 bp. Its sequencing revealed a 100% homology with the mouse SYT gene. These two SYT forms were present, although in different amounts, in all human normal tissues examined, including kidney, stomach, lung, colon, liver and synovia. Coexistence of N-SYT and I-SYT (both fused with SSX) was detected in a series of 59 SSs (35 monophasic and 24 biphasic) and in a SS cell line. A preliminary analysis of the differential expression levels of N-SYT and I-SYT in SSs revealed that the latter was consistently overexpressed, suggesting a role in SS pathogenesis. © 2001 Cancer Research Campaign http://www.bjcancer.co

Numerical analyses of underground openings in competent rock masses: continuous vs discontinuous

The paper is aimed at comparing the results of numerical analyses of underground openings in competent rock masses like the Carrara Marble (Italy) by considering a real and well documented case study. More specifically, 3D FEM and DEM analyses were carried out on a rock-mass model interested by two faults and three sets of discontinuities. The geometrical model is representative of deep underground openings where spalling - cracks and rock bursts can occur. PLAXIS 3D and 3DEC were used for the analyses. Intact rock and rock mass characterization of Carrara Marble was inferred from available technical literature. The analysis results were compared in terms of principal stresses and displacements in a number of monitoring points around the opening. The main practical interest is to find out a reliable approach for evaluating the stability of very large openings in a competent rock mass like Carrara marble. For such a purpose, a number of available in-situ stress measurements were used