Study of groundwaters using the environmental tritium and hydrochemical data in the Belgrade region

A study of tritium content and some physicochemical parameters has been performed in order to investigate interconnection between surface and atmospheric waters and underground waters in Belgrade area. Samples of the precipitation at Zeleno Brdo-Belgrade meteorological station, the Danube and the Sava river water, and underground water (Ranney wells and piezometers) have been analyzed. The3H content, the content of dissolved ions, total hardness, and electrical conductivity have been measured. The tritium data show existence of two water strata in the aquifer. The upper stratum (about 16 m thick) contains older water (mean monthly3H concentration of 17 TU) and has weak interaction with the river and the precipitation. Below this stratum lies the principal water bearing stratum, strongly connected with the river with the3H concentration similar to that of surface water (mean monthly3H concentration of 50 TU) and spreading out through the entire aquifer. The contribution of the Sava river water and the two water layers at the Ranney well are calculated starting with the hydrological aquifer model, which supposes that three water components are mixed in the pumped Ranney well water. According to calculation results using the3H concentration and physicochemical characteristics as parameters, more than 70 percent of the water pumped by the Ranney well (in 1983) comes from the Sava with a time delay of less that 15 days. Properties of tritium distribution in precipitation, river waters, and underground water in the Belgrade region are established from the results of measurements of3H concentrations in the period 1976-1983

Isotopic Investigation of the Surdulica Geothermal System

From the 13th International Radiocarbon Conference held in Dubrovnik, Yugoslavia, June 20-25, 1988.The object of our investigation was to study a mechanism of water formation in the Surdulica geothermal system (recharge area, age and homogeneity of the waters). We collected 56 samples to determine the chemical, stable isotope, 14C and tritium content of the waters. We found large stable isotope variations in precipitation collected at different altitudes, whereas the geothermal waters are largely homogeneous and seasonally independent. Data on springs and rivers, the local meteoric water line and recharge; area were obtained. Three groups of groundwater were identified by age modern from natural springs, old from mines and very old from the Vranjska Banja. Because the initial 14C activity of infiltrated waters from the recharge area is unknown, the age of thermal waters can only be inferred, from HCO3-, 14C and 3H content, to be 10,000 to 28,000 years old.This material was digitized as part of a cooperative project between Radiocarbon and the University of Arizona Libraries.The Radiocarbon archives are made available by Radiocarbon and the University of Arizona Libraries. Contact [email protected] for further information.Migrated from OJS platform February 202

SMAD7 variant rs4939827 is associated with colorectal cancer risk in Croatian population

BACKGROUND: Twenty common genetic variants have been associated with risk of developing colorectal cancer (CRC) in genome wide association studies to date. Since large differences between populations exist, generalisability of findings to any specific population needs to be confirmed. ----- AIM: The aim of this study was to perform an association study between risk variants: rs10795668, rs16892766, rs3802842 and rs4939827 and CRC risk in Croatian population. ----- METHODS: An association study was performed on 320 colorectal cancer cases and 594 controls recruited in Croatia. We genotyped four variants previously associated with CRC: rs10795668, rs16892766, rs3802842 and rs4939827. ----- RESULTS: SMAD7 variant rs4939827 (18q21.1) was significantly associated with CRC risk in Croatian population. C allele was associated with a decreased risk, odds ratio (OR): 0.70 (95% CI: 0.57-0.85, P=3.5E-04). Compared to TT homozygotes, risk was reduced by 34% in heterozygotes (OR=0.66, 95% CI: 0.47-0.92) and by 52% in CC homozygotes (OR=0.48, 95% CI: 0.33-0.72). ----- CONCLUSION: Our results show association of rs4939827 with colorectal cancer risk in Croatian population. The higher strength of the association in comparison to other studies suggests population-specific environmental or genetic factors may be modifying the association. More studies are needed to further describe role of rs4939827 in CRC. Likely reason for failure of replication for other 3 loci is inadequate study power

Comparing treatment outcomes of various intracranial bifurcation aneurysms locations using the Woven EndoBridge (WEB) device

BACKGROUND: The Woven EndoBridge (WEB) device has Food and Drug Administration approval for treatment of wide-necked intracranial bifurcation aneurysms. The WEB device has been shown to result in adequate occlusion in bifurcation aneurysms overall, but its usefulness in the individual bifurcation locations has been evaluated separately only in few case series, which were limited by small sample sizes. OBJECTIVE: To compare angiographic and clinical outcomes after treatment of bifurcation aneurysms at various locations, including anterior communicating artery (AComA), anterior cerebral artery (ACA) bifurcation distal to AComA, basilar tip, internal carotid artery (ICA) bifurcation, and middle cerebral artery (MCA) bifurcation aneurysms using the WEB device. METHODS: A retrospective cohort analysis was conducted at 22 academic institutions worldwide to compare treatment outcomes of patients with intracranial bifurcation aneurysms using the WEB device. Data include patient and aneurysm characteristics, procedural details, angiographic and functional outcomes, and complications. RESULTS: A total of 572 aneurysms were included. MCA (36%), AComA (35.7%), and basilar tip (18.9%) aneurysms were most common. The rate of adequate aneurysm occlusion was significantly higher for basilar tip (91.6%) and ICA bifurcation (96.7%) aneurysms and lower for ACA bifurcation (71.4%) and AComA (80.6%) aneurysms (p=0.04). CONCLUSION: To our knowledge, this is the most extensive study to date that compares the treatment of different intracranial bifurcation aneurysms using the WEB device. Basilar tip and ICA bifurcation aneurysms showed significantly higher rates of aneurysm occlusion than other locations