ANTIDIABETIC AND ANTIHYPERLIPIDAEMIC ACTIVITY OF SONERILA TINNEVELLIENSIS FISCHER WHOLE PLANT IN ALLOXAN INDUCED DIABETIC RATS

Objective: The ethanol extract of Sonerila tinnevelliensis Fischer whole plant was investigated for its antidiabetic and antihyperlipidaemic effect in Wistar Albino rats. Methods: Diabetes was induced in Albino rats by administration of alloxan monohydrate (150 mg/kg, i. p). The ethanol extracts of S. tinnevelliensis at a dose of 200 and 400 mg/kg of body weight were administered at single dose per day to diabetes induced rats for a period of 14 d. The effect of ethanol extract of S. tinnevelliensis whole plant extract on blood glucose, plasma insulin, creatinine, urea, glycosylated haemoglobin, serum lipid profile [total cholesterol (TC), triglycerides (TG), low density lipoprotein–cholesterol (LDL-C), very low density lipoprotein–cholesterol (VLDL-C), high density lipoprotein–cholesterol (HDL-C) and phospholipid (PL)] serum protein, albumin, globulin, serum enzymes [serum glutamate pyruvate transaminases (SGPT), serum glutamate oxaloacetate transaminases (SGOT), and alkaline phosphatase (ALP)] were measured in the diabetic rats. Results: The ethanol extract of S. tinnevelliensis whole plant elicited significant reductions of blood glucose (p<0.05), lipid parameters except HDL-C, serum enzymes and significantly increased HDL-C. The extracts also caused significant increase in plasma insulin (p<0.05) in the diabetic rats. Conclusion: The ethanol extracts of S. tinnevelliensis whole plant possesses significant antidiabetic and antihyperlipidaemic effects in alloxan induced diabetic rats