Monocarboxylate transporters in the brain and in cancer.

Monocarboxylate transporters (MCTs) constitute a family of 14 members among which MCT1-4 facilitate the passive transport of monocarboxylates such as lactate, pyruvate and ketone bodies together with protons across cell membranes. Their anchorage and activity at the plasma membrane requires interaction with chaperon protein such as basigin/CD147 and embigin/gp70. MCT1-4 are expressed in different tissues where they play important roles in physiological and pathological processes. This review focuses on the brain and on cancer. In the brain, MCTs control the delivery of lactate, produced by astrocytes, to neurons, where it is used as an oxidative fuel. Consequently, MCT dysfunctions are associated with pathologies of the central nervous system encompassing neurodegeneration and cognitive defects, epilepsy and metabolic disorders. In tumors, MCTs control the exchange of lactate and other monocarboxylates between glycolytic and oxidative cancer cells, between stromal and cancer cells and between glycolytic cells and endothelial cells. Lactate is not only a metabolic waste for glycolytic cells and a metabolic fuel for oxidative cells, but it also behaves as a signaling agent that promotes angiogenesis and as an immunosuppressive metabolite. Because MCTs gate the activities of lactate, drugs targeting these transporters have been developed that could constitute new anticancer treatments. This article is part of a Special Issue entitled: Mitochondrial Channels edited by Pierre Sonveaux, Pierre Maechler and Jean-Claude Martinou

Magnetization profiles and NMR spectra of doped Haldane chains at finite temperatures

Open segments of S=1 antiferromagnetic spin chains are studied at finite temperatures and fields using continuous time Quantum Monte Carlo techniques. By calculating the resulting magnetization profiles for a large range of chain lengths with fixed field and temperature we reconstruct the experimentally measured NMR spectrum of impurity doped Y$_2$BaNi$_{1-x}$Mg$_x$O$_5$. For temperatures above the gap the calculated NMR spectra are in excellent agreement with the experimental results, confirming the existence of $S=1/2$ excitations at the end of open S=1 chain segments. At temperatures below the gap, neglecting inter chain couplings, we still find well defined peaks in the calculated NMR spectra corresponding to the $S=1/2$ chain end excitations. At low temperatures, inter chain couplings could be important, resulting in a more complicated phase.Comment: 7 pages, 5 figures, minor correction

Dynamics and transport in random quantum systems governed by strong-randomness fixed points

We present results on the low-frequency dynamical and transport properties of random quantum systems whose low temperature ($T$), low-energy behavior is controlled by strong disorder fixed points. We obtain the momentum and frequency dependent dynamic structure factor in the Random Singlet (RS) phases of both spin-1/2 and spin-1 random antiferromagnetic chains, as well as in the Random Dimer (RD) and Ising Antiferromagnetic (IAF) phases of spin-1/2 random antiferromagnetic chains. We show that the RS phases are unusual `spin metals' with divergent low-frequency spin conductivity at T=0, and we also follow the conductivity through novel `metal-insulator' transitions tuned by the strength of dimerization or Ising anisotropy in the spin-1/2 case, and by the strength of disorder in the spin-1 case. We work out the average spin and energy autocorrelations in the one-dimensional random transverse field Ising model in the vicinity of its quantum critical point. All of the above calculations are valid in the frequency dominated regime \omega \agt T, and rely on previously available renormalization group schemes that describe these systems in terms of the properties of certain strong-disorder fixed point theories. In addition, we obtain some information about the behavior of the dynamic structure factor and dynamical conductivity in the opposite `hydrodynamic' regime $\omega < T$ for the special case of spin-1/2 chains close to the planar limit (the quantum x-y model) by analyzing the corresponding quantities in an equivalent model of spinless fermions with weak repulsive interactions and particle-hole symmetric disorder.Comment: Long version (with many additional results) of Phys. Rev. Lett. {\bf 84}, 3434 (2000) (available as cond-mat/9904290); two-column format, 33 pages and 8 figure

Defining freshwater as a natural resource: a framework linking water use to the area of protection natural resources

© 2019, Springer-Verlag GmbH Germany, part of Springer Nature. Purpose: While many examples have shown unsustainable use of freshwater resources, existing LCIA methods for water use do not comprehensively address impacts to natural resources for future generations. This framework aims to (1) define freshwater resource as an item to protect within the Area of Protection (AoP) natural resources, (2) identify relevant impact pathways affecting freshwater resources, and (3) outline methodological choices for impact characterization model development. Methods: Considering the current scope of the AoP natural resources, the complex nature of freshwater resources and its important dimensions to safeguard safe future supply, a definition of freshwater resource is proposed, including water quality aspects. In order to clearly define what is to be protected, the freshwater resource is put in perspective through the lens of the three main safeguard subjects defined by Dewulf et al. (2015). In addition, an extensive literature review identifies a wide range of possible impact pathways to freshwater resources, establishing the link between different inventory elementary flows (water consumption, emissions, and land use) and their potential to cause long-term freshwater depletion or degradation. Results and discussion: Freshwater as a resource has a particular status in LCA resource assessment. First, it exists in the form of three types of resources: flow, fund, or stock. Then, in addition to being a resource for human economic activities (e.g., hydropower), it is above all a non-substitutable support for life that can be affected by both consumption (source function) and pollution (sink function). Therefore, both types of elementary flows (water consumption and emissions) should be linked to a damage indicator for freshwater as a resource. Land use is also identified as a potential stressor to freshwater resources by altering runoff, infiltration, and erosion processes as well as evapotranspiration. It is suggested to use the concept of recovery period to operationalize this framework: when the recovery period lasts longer than a given period of time, impacts are considered to be irreversible and fall into the concern of freshwater resources protection (i.e., affecting future generations), while short-term impacts effect the AoP ecosystem quality and human health directly. It is shown that it is relevant to include this concept in the impact assessment stage in order to discriminate the long-term from the short-term impacts, as some dynamic fate models already do. Conclusions: This framework provides a solid basis for the consistent development of future LCIA methods for freshwater resources, thereby capturing the potential long-term impacts that could warn decision makers about potential safe water supply issues in the future

Nomenclature for renal replacement therapy and blood purification techniques in critically ill patients: practical applications

This article reports the conclusions of the second part of a consensus expert conference on the nomenclature of renal replacement therapy (RRT) techniques currently utilized to manage acute kidney injury and other organ dysfunction syndromes in critically ill patients. A multidisciplinary approach was taken to achieve harmonization of definitions, components, techniques, and operations of the extracorporeal therapies. The article describes the RRT techniques in detail with the relevant technology, procedures, and phases of treatment and key aspects of volume management/fluid balance in critically ill patients. In addition, the article describes recent developments in other extracorporeal therapies, including therapeutic plasma exchange, multiple organ support therapy, liver support, lung support, and blood purification in sepsis. This is a consensus report on nomenclature harmonization in extracorporeal blood purification therapies, such as hemofiltration, plasma exchange, multiple organ support therapies, and blood purification in sepsis

Comparison of S=0 and S=1/2 Impurities in Haldane Chain Compound, Y2BaNiO5Y_{2}BaNiO_{5}

We present the effect of Zn (S=0) and Cu (S=1/2) substitution at the Ni site of S=1 Haldane chain compound $Y_{2}BaNiO_{5}$. $^{89}$Y NMR allows us to measure the local magnetic susceptibility at different distances from the defects. The $^{89}$Y NMR spectrum consists of one central peak and several less intense satellite peaks. The shift of the central peak measures the uniform susceptibility, which displays a Haldane gap $Delta$$equiv$100 K and it corresponds to an AF coupling J$equiv$260 K between the near-neighbor Ni spins. Zn or Cu substitution does not affect the Haldane gap. The satellites, which are evenly distributed on the two sides of the central peak, probe the antiferromagnetic staggered magnetization near the substituted site, which decays exponentially. Its extension is found identical for both impurities and corresponds accurately to the correlation length $xi$(T) determined by Monte Carlo (QMC) simulations for the pure compound. In the case of non-magnetic Zn, the temperature dependence of the induced magnetization is consistent with a Curie law with an "effective" spin S=0.4 on each side of Zn, which is well accounted by Quantum Monte Carlo computations of the spinless-defect-induced magnetism. In the case of magnetic Cu, the similarity of the induced magnetism to the Zn case implies a weak coupling of the Cu spin to the nearest- neighbor Ni spins. The slight reductionin the induced polarization with respect to Zn is reproduced by QMC computations by considering an antiferromagnetic coupling of strength J'=0.1-0.2 J between the S=1/2 Cu-spin and nearest-neighbor Ni-spin.Comment: 15 pages, 18 figures, submitted to Physical Review

A New Measurement of the π0\pi^0 Radiative Decay Width

High precision measurements of the differential cross sections for $\pi^0$ photoproduction at forward angles for two nuclei, $^{12}$C and $^{208}$Pb, have been performed for incident photon energies of 4.9 - 5.5 GeV to extract the ${\pi^0 \to \gamma\gamma}$ decay width. The experiment was done at Jefferson Lab using the Hall B photon tagger and a high-resolution multichannel calorimeter. The ${\pi^0 \to \gamma\gamma}$ decay width was extracted by fitting the measured cross sections using recently updated theoretical models for the process. The resulting value for the decay width is $\Gamma{(\pi^0 \to \gamma\gamma)} = 7.82 \pm 0.14 ~({\rm stat.}) \pm 0.17 ~({\rm syst.}) ~{\rm eV}$. With the 2.8% total uncertainty, this result is a factor of 2.5 more precise than the current PDG average of this fundamental quantity and it is consistent with current theoretical predictions.Comment: 4 pages, 5 figure

Diffusive energy transport in the S=1 Haldane chain compound AgVP2S6

We present the results of measurements of the thermal conductivity $\kappa$ of the spin S=1 chain compound AgVP_2S_6 in the temperature range between 2 and 300 K and with the heat flow directed either along or perpendicular to the chain direction. The analysis of the anisotropy of the heat transport allowed for the identification of a small but non-negligible magnon contribution $\kappa_m$ along the chains, superimposed on the dominant phonon contribution $\kappa_ph$. At temperatures above about 100 K the energy diffusion constant D_E(T), calculated from the $\kappa_m(T)$ data, exhibits similar features as the spin diffusion constant D_S(T), previously measured by NMR. In this regime, the behaviour of both transport parameters is consistent with a diffusion process that is caused by interactions inherent to one-dimensional S=1 spin systems.Comment: 6 pages, 4 figure