62,199 research outputs found
Strontium isotope stratigraphy in the Late Cretaceous: Numerical calibration of the Sr isotope curve and intercontinental correlation for the campanian
The white Chalk exposed in quarries at Lagerdorf and Kronsmoor, northwestern Germany, provides a standard section for the European Upper Cretaceous. The Sr-87/Sr-86 values of nannofossil chalk and belemnite calcite increase upward through 330 m of section, from less than or equal to 0.70746 in the Upper Santonian to greater than or equal to 0.70777 in the Lower Maastrichtian. The data define three linear trends separated by major points of inflection at stratigraphic heights in the section of 162 m (75.5 Ma) in the Upper Campanian Galerites vulgaris zone and at -6 m (82.9 Ma), just above the base of the Campanian in the Inoceramus lingua/Goniateuthis quadrata zone. The temporal rate of change of Sr-87/Sr-86 was constant through each of the linear segments of our isotope ''curve'' when viewed at the resolution of our average sampling interval (0.15 m.y.). Fine structure, if rear, may record brief (<100 kyr) excursions of (SrSr)-Sr-87-Sr-86 from values expected from the overall trends. In Lagerdorf, the boundary between the Santonian and Campanian stages, taken here as the level of first occurrence of the belemnite Gonioteuthis granulataquadrata, has an Sr-87/Sr-86 Of 0.707473 +/- 5. This is within error of the values of 0.707457 +/- 16 for this boundary in the U.S. western interior (base of the Scaphites leei III zone) and 0.707479 +/- 9 for this boundary in the English Chalk (top of the Marsupites testudinarius zone). In Kronsmoor, the boundary between the Campanian and Maastrichtian stages, taken here as the level of first occurrence of the belemnite Belemnella lanceolata, has an Sr-87/Sr-86 of 0.707723 +/- 4. This is within error of the values of 0.707725 +/- 20 for this boundary in the U.S. western interior (base of the Baculites eliasi zone) and 0.707728 +/- 5 for this boundary in the English Chalk (defined as in Germany)
Conformal Symmetry for Black Holes in Four Dimensions
We show that the asymptotic boundary conditions of general asymptotically
flat black holes in four dimensions can be modified such that a conformal
symmetry emerges. The black holes with the asymptotic geometry removed in this
manner satisfy the equations of motion of minimal supergravity in five
dimensions. We develop evidence that a two dimensional CFT dual of general
black holes in four dimensions account for their black hole entropy.Comment: 24 pages, minor correction
Post-functionalization of drug-loaded nanoparticles prepared by polymerization-induced self-assembly (PISA) with mitochondria targeting ligands
Herein, the postfunctionalization of different non-fouling PISA particles, prepared from either poly(oligo ethylene glycol methyl ether methacrylate) (pPEGMA) and the anticancer drug PENAO (4-(N-(S-penicillaminylacetyl)amino)phenylarsenonous acid) or zwitterionic 2-methacryloyloxyethyl phosphorylcholine (MPC) and PENAO were reported. Both PISA particles were reacted with triphenylphosphonium (TPP) as mitochondria targeting units in order to evaluate the changes in cellular uptake or the toxicity of the conjugated arsenic drug. Attachment of TPP onto the PISA particles however was found not to enhance the mitochondrial accumulation, but it did influence overall the biological activity of pMPC-based particles in 2D and 3D cultured sarcoma SW982 cells. When TPP was conjugated to the pMPC PISA particles more cellular uptake as well as better spheroid penetration were observed, while TPP on PEG-based PISA had only little effect. It was hypothesized that TPP on the micelle surface may not be accessible enough to allow mitochondria targeting, but more structural investigations are required to elucidate this
Conformal Symmetry for General Black Holes
We show that the warp factor of a generic asymptotically flat black hole in
five dimensions can be adjusted such that a conformal symmetry emerges. The
construction preserves all near horizon properties of the black holes, such as
the thermodynamic potentials and the entropy. We interpret the geometry with
modified asymptotic behavior as the "bare" black hole, with the ambient flat
space removed. Our warp factor subtraction generalizes hidden conformal
symmetry and applies whether or not rotation is significant. We also find a
relation to standard AdS/CFT correspondence by embedding the black holes in six
dimensions. The asymptotic conformal symmetry guarantees a dual CFT description
of the general rotating black holes.Comment: 26 page
Microscopics of Extremal Kerr from Spinning M5 Branes
We show that the spinning magnetic one-brane in minimal five-dimensional
supergravity admits a decoupling limit that interpolates smoothly between a
self-dual null orbifold of AdS_3 \times S^2 and the near-horizon limit of the
extremal Kerr black hole times a circle. We use this interpolating solution to
understand the field theory dual to spinning M5 branes as a deformation of the
Discrete Light Cone Quantized (DLCQ) Maldacena-Stominger-Witten (MSW) CFT. In
particular, the conformal weights of the operators dual to the deformation
around AdS_3 \times S^2 are calculated. We present pieces of evidence showing
that a CFT dual to the four-dimensional extremal Kerr can be obtained from the
deformed MSW CFT.Comment: 5 page
See-saw neutrino masses and large mixing angles in the vortex background on a sphere
In the vortex background on a sphere, a single 6-dimensional fermion family
gives rise to 3 zero-modes in the 4-dimensional point of view, which may
explain the replication of families in the Standard Model. Previously, it had
been shown that realistic hierarchical mass and mixing patterns can be
reproduced for the quarks and the charged leptons. Here, we show that the
addition of a single heavy 6-dimensional field that is gauge singlet, unbound
to the vortex, and embedded with a bulk Majorana mass enables to generate 4D
Majorana masses for the light neutrinos through the see-saw mechanism. The
scheme is very predictive. The hierarchical structure of the fermion zero-modes
leads automatically to an inverted pseudo-Dirac mass pattern, and always
predicts one maximal angle in the neutrino see-saw matrix. It is possible to
obtain a second large mixing angle from either the charged lepton or the
neutrino sector, and we demonstrate that this model can fit all observed data
in neutrino oscillations experiments. Also, U_{e3} is found to be of the order
~0.1.Comment: 23 pages, 1 figur
Entrectinib-related myocarditis in a young female patient with metastatic non-small cell lung cancer
A 51-year-old woman presented with a 2-week history of off balance, left lower limb weakness and neglect and neck pain radiating down the right arm. Investigations revealed a metastatic, ROS1 fusion-positive, non-small cell lung cancer, and treatment with entrectinib, a recently approved multikinase inhibitor, was started. Two weeks after, she was admitted to the emergency department with new-onset pressure-like chest pain and dyspnoea. Laboratory evaluation showed elevated troponin and mild left ventricular systolic dysfunction with reduced global longitudinal strain on transthoracic echocardiogram. Cardiac magnetic resonance revealed mild oedema and non-ischaemic fibrosis. A diagnosis of drug-induced myocarditis was made. Cardioprotective medication with an angiotensin-converting enzyme inhibitor and a beta-blocker was started. Entrectinib was temporarily discontinued and restarted at a reduced dose after a multidisciplinary team meeting involving both the oncology and cardio-oncology teams. This is the second described case of entrectinib-induced myocarditis and the first one without eosinophilia
symmetry and quasi-normal modes in the BTZ black hole
With the help of two new intrinsic tensor fields associated with the
quadratic Casimir of Killing fields, we uncover the
symmetry satisfied by the solutions to the equations of motion for various
fields in the BTZ black hole in a uniform way by performing tensor and spinor
analysis without resorting to any specific coordinate system. Then with the
standard algebraic method developed recently, we determine the quasi-normal
modes for various fields in the BTZ black hole. As a result, the quasi-normal
modes are given by the infinite tower of descendants of the chiral highest
weight mode, which is in good agreement with the previous analytic result
obtained by exactly solving equations of motion instead.Comment: JHEP style, 1+13 pages, version to appear in JHE
Fluid and Diffusion Limits for Bike Sharing Systems
Bike sharing systems have rapidly developed around the world, and they are
served as a promising strategy to improve urban traffic congestion and to
decrease polluting gas emissions. So far performance analysis of bike sharing
systems always exists many difficulties and challenges under some more general
factors. In this paper, a more general large-scale bike sharing system is
discussed by means of heavy traffic approximation of multiclass closed queueing
networks with non-exponential factors. Based on this, the fluid scaled
equations and the diffusion scaled equations are established by means of the
numbers of bikes both at the stations and on the roads, respectively.
Furthermore, the scaling processes for the numbers of bikes both at the
stations and on the roads are proved to converge in distribution to a
semimartingale reflecting Brownian motion (SRBM) in a -dimensional box,
and also the fluid and diffusion limit theorems are obtained. Furthermore,
performance analysis of the bike sharing system is provided. Thus the results
and methodology of this paper provide new highlight in the study of more
general large-scale bike sharing systems.Comment: 34 pages, 1 figure
Light-like polygonal Wilson loops in 3d Chern-Simons and ABJM theory
We study light-like polygonal Wilson loops in three-dimensional Chern-Simons
and ABJM theory to two-loop order. For both theories we demonstrate that the
one-loop contribution to these correlators cancels. For pure Chern-Simons, we
find that specific UV divergences arise from diagrams involving two cusps,
implying the loss of finiteness and topological invariance at two-loop order.
Studying those UV divergences we derive anomalous conformal Ward identities for
n-cusped Wilson loops which restrict the finite part of the latter to
conformally invariant functions. We also compute the four-cusp Wilson loop in
ABJM theory to two-loop order and find that the result is remarkably similar to
that of the corresponding Wilson loop in N=4 SYM. Finally, we speculate about
the existence of a Wilson loop/scattering amplitude relation in ABJM theory.Comment: 37 pages, many figures; v2: references added, minor changes; v3:
references added, sign error fixed and note adde
- …