double dissociation between the extrastriate body area and the posterior superior temporal sulcus during biological motion perception converging evidence from tms and fmri

Our brains engage numerous regions when exposed to biological motion, with the posterior superior temporal sulcus (pSTS) being the primary locus. The exact roles of hMT+ and the extrastriate body area (EBA) remain unclear. Here, we set out to determine the specific roles of pSTS and EBA during biological motion perception, focusing on walker orientation and walking direction. To obtain converging evidence, we conducted separate TMS and fMRI experiments within the same subjects (N = 12). Two separate tasks were used in the TMS study: walker orientation probing form processing and walking direction probing motion/sequence processing. Task performance was compared before and after applying repetitive offline TMS (1 Hz) over EBA and pSTS (based on fMRI-guided stereotaxy). In the fMRI study, EBA and pSTS were mapped in separate scans using standard localizers. Subsequently, runs with point-light walkers were subjected to MVPA, determining the amount of static (orientation) and dynamic (direction) information p..

Influence of Father’s Weight and Height on Weight of Male and Female Newborns

The study included 1,596 newborns and their parents living in Šibenik County, Croatia. All newborns are born between 37 and 42 weeks of gestation, with no congenital anomalies and from a single pregnancy. Fathers and mothers of male babies are older than those of girl babies (p < 0.01). Mean values for weight, height, BMI in parents and the woman’s parity are equal (p = 0.05). Pregnancy with male baby lasts longer and the babies are heavier (p < 0.05). Where the fathers weight between 70 and 79 kg and 80 to 89 kg, and where the fathers are 175 to 179 cm or 180 to 184 cm tall with normal BMI the male babies are heavier than the females at birth (p < 0.05). Increased weight, height and BMI in the father increase the birth weight of both male and female babies (p < 0.00001). The authors concludes that parents (father and/or mother) of male babies are older than those of girls, that pregnancy for males babies lasts longer and that male babies are born heavier than girls. With increased weight, and height and BMI in the father, the birth weight of both male and female babies increases

A Recurrent Intragenic Deletion in the Desmoglein 4 Gene Underlies Localized Autosomal Recessive Hypotrichosis

6 páginas, 2 figuras.A newly defined form of inherited hair loss, named localized autosomal recessive hypotrichosis (LAH, OMIM 607903), was recently described in the literature (Kljuic et al. 2003a; Rafique et al. 2003) and shown to be linked to chromosome 18. We identified a large, intragenic deletion in the desmoglein 4 gene (DSG4) as the underlying mutation in two unrelated families of Pakistani origin (Kljuic et al. 2003a). LAH is an autosomal recessive form of hypotrichosis affecting the scalp, trunk, and extremities, and largely sparing the facial, pubic, and axillary hair. Typical hairs are fragile and break easily, leaving short sparse scalp hairs with a characteristic appearance. Using comparative genomics, we also demonstrated that human LAH is allelic with the lanceolate hair (lah) mouse (Kljuic et al. 2003a), as well as the lanceolate hair (lah) rat phenotype (Jahoda et al. 2004). In order to expand the series of allelic mutations in the desmoglein 4 gene underlying LAH in humans, we begin molecular analysis of DSG4 in families from around the world. Here, we describe the study of a family of Pakistani origin with two siblings affected with LAH (Figure 1).This study was supported in part by grants USPHS NIH R01-AR44924 and the March of Dimes Birth Defects Foundation (A. M. C.).Peer reviewe

Effect of Insulin and Insulin-Like Growth Factor I on Fetal Macrosomia in Healthy Women

The aim of the study was to determine the values of insulin, insulin-like growth factor I (IGF- I) and glucose in the umbilical cord blood of macrosomic ( 4000 g) and control (3,000–3,500 g) infants born to healthy mothers, and to assess their possible correlation with the newborns’ birth weight and maternal anthropometric parameters. A series of 207 macrosomic term infants, and 200 control term infants, born to healthy mothers with normal oral glucose tolerance test throughout gestation, were studied. The glucose concentration did not differ between the macrosomic and control group while macrosomic infants had significantly higher values of insulin and IGF-I. Female macrosomic infants had significantly higher levels of insulin and IGF-I than male macrosomic infants. The levels of insulin and IGF-I, but not levels of glucose, differed between the macrosomic and control group according to the maternal weight, height, pregestational body mass index, weight gain during gestation, and maternal birth weight. The maternal anthropometric parameters were significantly greater in the macrosomic infants. Accordingly, macrosomia was concluded to be a multifactorial condition

On the interplay of temporal resolution power and spatial suppression in their prediction of psychometric intelligence.

As a measure of the brain's temporal fine-tuning capacity, temporal resolution power (TRP) explained repeatedly a substantial amount of variance in psychometric intelligence. Recently, spatial suppression, referred to as the increasing difficulty in quickly perceiving motion direction as the size of the moving stimulus increases, has attracted particular attention, when it was found to be positively related to psychometric intelligence. Due to the conceptual similarities of TRP and spatial suppression, the present study investigated their mutual interplay in the relation to psychometric intelligence in 273 young adults to better understand the reasons for these relationships. As in previous studies, psychometric intelligence was positively related to a latent variable representing TRP but, in contrast to previous reports, negatively to latent and manifest measures of spatial suppression. In a combined structural equation model, TRP still explained a substantial amount of variance in psychometric intelligence while the negative relation between spatial suppression and intelligence was completely explained by TRP. Thus, our findings confirmed TRP to be a robust predictor of psychometric intelligence but challenged the assumption of spatial suppression as a representation of general information processing efficiency as reflected in psychometric intelligence. Possible reasons for the contradictory findings on the relation between spatial suppression and psychometric intelligence are discussed

Cognitive and Neural Effects of Vision-Based Speed-of-Processing Training in Older Adults with Amnestic Mild Cognitive Impairment: A Pilot Study

Objectives: To examine the cognitive and neural effects of vision-based speed-of-processing (VSOP) training in older adults with amnestic mild cognitive impairment (aMCI) and contrast those effects with an active control (mental leisure activities (MLA)). Design: Randomized single-blind controlled pilot trial. Setting: Academic medical center. Participants: Individuals with aMCI (N = 21). Intervention: Six-week computerized VSOP training. Measurements: Multiple cognitive processing measures, instrumental activities of daily living (IADLs), and two resting state neural networks regulating cognitive processing: central executive network (CEN) and default mode network (DMN). Results: VSOP training led to significantly greater improvements in trained (processing speed and attention: F1,19 = 6.61, partial η2 = 0.26, P = .02) and untrained (working memory: F1,19 = 7.33, partial η2 = 0.28, P = .01; IADLs: F1,19 = 5.16, partial η2 = 0.21, P = .03) cognitive domains than MLA and protective maintenance in DMN (F1, 9 = 14.63, partial η2 = 0.62, P = .004). VSOP training, but not MLA, resulted in a significant improvement in CEN connectivity (Z = −2.37, P = .02). Conclusion: Target and transfer effects of VSOP training were identified, and links between VSOP training and two neural networks associated with aMCI were found. These findings highlight the potential of VSOP training to slow cognitive decline in individuals with aMCI. Further delineation of mechanisms underlying VSOP-induced plasticity is necessary to understand in which populations and under what conditions such training may be most effective

Mutations in the Cholesterol Transporter Gene ABCA5 Are Associated with Excessive Hair Overgrowth

Inherited hypertrichoses are rare syndromes characterized by excessive hair growth that does not result from androgen stimulation, and are often associated with additional congenital abnormalities. In this study, we investigated the genetic defect in a case of autosomal recessive congenital generalized hypertrichosis terminalis (CGHT) (OMIM135400) using whole-exome sequencing. We identified a single base pair substitution in the 5′ donor splice site of intron 32 in the ABC lipid transporter gene ABCA5 that leads to aberrant splicing of the transcript and a decrease in protein levels throughout patient hair follicles. The homozygous recessive disruption of ABCA5 leads to reduced lysosome function, which results in an accumulation of autophagosomes, autophagosomal cargos as well as increased endolysosomal cholesterol in CGHT keratinocytes. In an unrelated sporadic case of CGHT, we identified a 1.3 Mb cryptic deletion of chr17q24.2-q24.3 encompassing ABCA5 and found that ABCA5 levels are dramatically reduced throughout patient hair follicles. Collectively, our findings support ABCA5 as a gene underlying the CGHT phenotype and suggest a novel, previously unrecognized role for this gene in regulating hair growth

Eye Movements Affect Postural Control in Young and Older Females

Visual information is used for postural stabilization in humans. However, little is known about how eye movements prevalent in everyday life interact with the postural control system in older individuals. Therefore, the present study assessed the effects of stationary gaze fixations, smooth pursuits, and saccadic eye movements, with combinations of absent, fixed and oscillating large-field visual backgrounds to generate different forms of retinal flow, on postural control in healthy young and older females. Participants were presented with computer generated visual stimuli, whilst postural sway and gaze fixations were simultaneously assessed with a force platform and eye tracking equipment, respectively. The results showed that fixed backgrounds and stationary gaze fixations attenuated postural sway. In contrast, oscillating backgrounds and smooth pursuits increased postural sway. There were no differences regarding saccades. There were also no differences in postural sway or gaze errors between age groups in any visual condition. The stabilizing effect of the fixed visual stimuli show how retinal flow and extraocular factors guide postural adjustments. The destabilizing effect of oscillating visual backgrounds and smooth pursuits may be related to more challenging conditions for determining body shifts from retinal flow, and more complex extraocular signals, respectively. Because the older participants matched the young group's performance in all conditions, decreases of posture and gaze control during stance may not be a direct consequence of healthy aging. Further research examining extraocular and retinal mechanisms of balance control and the effects of eye movements, during locomotion, is needed to better inform fall prevention interventions

The Barretos Cancer Hospital Animal Facility: implementation and results of a dedicated platform for preclinical oncology models

The Barretos Cancer Hospital Animal Facility (BCHAF) is a unique facility in Brazil exclusively dedicated to working with animal models for cancer research. In this article, we briefly present our modern facility and the main experiments performed, focusing on mutant strains of mice (PTCH-knockout and ApcMin mice), xenograft models, and patient-derived xenografts (PDXs). Our results show the progress and challenges in establishing these models and the need for having an appropriate representation of our cancer population to better understand tumor biology and to identify cancer biomarkers, which could be putatively targeted, allowing for personalized therapy.This study was funded by the Public Ministry of Labor Campinas (Research, Prevention and Education of Occupational Cancer) and by Pio XII Foundation, Barretos Cancer Hospital internal funds, Grant Number: 13/2021

Manipulation of Pre-Target Activity on the Right Frontal Eye Field Enhances Conscious Visual Perception in Humans

The right Frontal Eye Field (FEF) is a region of the human brain, which has been consistently involved in visuo-spatial attention and access to consciousness. Nonetheless, the extent of this cortical site’s ability to influence specific aspects of visual performance remains debated. We hereby manipulated pre-target activity on the right FEF and explored its influence on the detection and categorization of low-contrast near-threshold visual stimuli. Our data show that pre-target frontal neurostimulation has the potential when used alone to induce enhancements of conscious visual detection. More interestingly, when FEF stimulation was combined with visuo-spatial cues, improvements remained present only for trials in which the cue correctly predicted the location of the subsequent target. Our data provide evidence for the causal role of the right FEF pre-target activity in the modulation of human conscious vision and reveal the dependence of such neurostimulatory effects on the state of activity set up by cue validity in the dorsal attentional orienting network