Estimation of energy and material use of sintering-based construction for a lunar outpost - with the example of SinterHab module design

In this paper, we would revisit the usability of microwave for lunar regolith sintering through an in-depth experiment, and examine the minimum materials and energy required for sintering based on the SinterHab design. This will include the minimum layers to print, estimated printing time, minimum energy required for the sintering process and the potential energy sources

A study of the personal income distribution in Australia

We analyze the data on personal income distribution from the Australian Bureau of Statistics. We compare fits of the data to the exponential, log-normal, and gamma distributions. The exponential function gives a good (albeit not perfect) description of 98% of the population in the lower part of the distribution. The log-normal and gamma functions do not improve the fit significantly, despite having more parameters, and mimic the exponential function. We find that the probability density at zero income is not zero, which contradicts the log-normal and gamma distributions, but is consistent with the exponential one. The high-resolution histogram of the probability density shows a very sharp and narrow peak at low incomes, which we interpret as the result of a government policy on income redistribution.Comment: 7 pages, 4 figures, Proceedings of the Econophysics Colloquium, Canberra, 14-18 November 200

Petrology and geochemistry of nakhlite MIL 03346: A new Martian meteorite from Antarctica

MIL 03346 is the first nakhlite in the US Antarctic collection. We have performed detailed mineralogical and bulk-geochemical investigations to compare petrogenesis of this Martian meteorite with other nakhlites

Crystal field states of Kondo lattice heavy fermions CeRuSn3 and CeRhSn3

Inelastic neutron scattering experiments have been carried out to determine the crystal field states of the Kondo lattice heavy fermions CeRuSn3 and CeRhSn3. Both the compounds crystallize in LaRuSn3-type cubic structure (space group Pm-3n) in which the Ce atoms occupy two distinct crystallographic sites with cubic (m-3) and tetragonal (-4m.2) point symmetries. The INS data of CeRuSn3 reveal the presence of a broad excitation centered around 6-8 meV which is accounted by a model based on crystal electric field (CEF) excitations. On the other hand, the INS data of isostructural CeRhSn3 reveal three CEF excitations around 7.0, 12.2 and 37.2 meV. The neutron intensity sum rule indicates that the Ce ions at both cubic and tetragonal Ce sites are in Ce3+ state in both CeRuSn3 and CeRhSn3. The CEF level schemes for both the compounds are deduced. We estimate the Kondo temperature T_K = 3.1(2) K for CeRuSn3 from neutron quasielastic linewidth in excellent agreement with that determined from the scaling of magnetoresistance which gives T_K = 3.2(1) K. For CeRhSn3 the neutron quasielastic linewidth gives T_K = 4.6 K. For both CeRuSn3 and CeRhSn3, the ground state of Ce3+ turns out to be a quartet for the cubic site and a doublet for the tetragonal site.Comment: 12 pages, 13 figures, 2 tables, to appear in Phys. Rev.

Formulation and characterization of an apigenin-phospholipid phytosome (APLC) for improved solubility, in vivo bioavailability, and antioxidant potential

The apigenin-phospholipid phytosome (APLC) was developed to improve the aqueous solubility, dissolution, in vivo bioavailability, and antioxidant activity of apigenin. The APLC synthesis was guided by a full factorial design strategy, incorporating specific formulation and process variables to deliver an optimized product. The design-optimized formulation was assayed for aqueous solubility, in vitro dissolution, pharmacokinetics, and antioxidant activity. The pharmacological evaluation was carried out by assessing its effects on carbon tetrachloride-induced elevation of liver function marker enzymes in a rat model. The antioxidant activity was assessed by studying its effects on the liver antioxidant marker enzymes. The developed model was validated using the design-optimized levels of formulation and process variables. The physical-chemical characterization confirmed the formation of phytosomes. The optimized formulation demonstrated over 36-fold higher aqueous solubility of apigenin, compared to that of pure apigenin. The formulation also exhibited a significantly higher rate and extent of apigenin release in dissolution studies. The pharmacokinetic analysis revealed a significant enhancement in the oral bioavailability of apigenin from the prepared formulation, compared to pure apigenin. The liver function tests indicated that the prepared phytosome showed a significantly improved restoration of all carbon tetrachloride-elevated rat liver function marker enzymes. The prepared formulation also exhibited antioxidant potential by significantly increasing the levels of glutathione, superoxide dismutase, catalase, and decreasing the levels of lipid peroxidase. The study shows that phospholipid-based phytosome is a promising and viable strategy for improving the delivery of apigenin and similar phytoconstituents with low aqueous solubility

Mechanisms underlying clinical efficacy of Angiotensin II type 2 receptor (AT(2)R) antagonist EMA401 in neuropathic pain: clinical tissue and in vitro studies

BACKGROUND: The clinical efficacy of the Angiotensin II (AngII) receptor AT(2)R antagonist EMA401, a novel peripherally-restricted analgesic, was reported recently in post-herpetic neuralgia. While previous studies have shown that AT(2)R is expressed by nociceptors in human DRG (hDRG), and that EMA401 inhibits capsaicin responses in cultured hDRG neurons, the expression and levels of its endogenous ligands AngII and AngIII in clinical neuropathic pain tissues, and their signalling pathways, require investigation. We have immunostained AngII, AT(2)R and the capsaicin receptor TRPV1 in control post-mortem and avulsion injured hDRG, control and injured human nerves, and in cultured hDRG neurons. AngII, AngIII, and Ang-(1-7) levels were quantified by ELISA. The in vitro effects of AngII, AT(2)R agonist C21, and Nerve growth factor (NGF) were measured on neurite lengths; AngII, NGF and EMA401 effects on expression of p38 and p42/44 MAPK were measured using quantitative immunofluorescence, and on capsaicin responses using calcium imaging. RESULTS: AngII immunostaining was observed in approximately 75% of small/medium diameter neurons in control (n = 5) and avulsion injured (n = 8) hDRG, but not large neurons i.e. similar to TRPV1. AngII was co-localised with AT(2)R and TRPV1 in hDRG and in vitro. AngII staining by image analysis showed no significant difference between control (n = 12) and injured (n = 13) human nerves. AngII levels by ELISA were also similar in control human nerves (4.09 ± 0.36 pmol/g, n = 31), injured nerves (3.99 ± 0.79 pmol/g, n = 7), and painful neuromas (3.43 ± 0.73 pmol/g, n = 12); AngIII and Ang-(1-7) levels were undetectable (<0.03 and 0.05 pmol/g respectively). Neurite lengths were significantly increased in the presence of NGF, AngII and C21 in cultured DRG neurons. AngII and, as expected, NGF significantly increased signal intensity of p38 and p42/44 MAPK, which was reversed by EMA401. AngII mediated sensitization of capsaicin responses was not observed in the presence of MAP kinase inhibitor PD98059, and the kinase inhibitor staurosporine. CONCLUSION: The major AT(2)R ligand in human peripheral nerves is AngII, and its levels are maintained in injured nerves. EMA401 may act on paracrine/autocrine mechanisms at peripheral nerve terminals, or intracrine mechanisms, to reduce neuropathic pain signalling in AngII/NGF/TRPV1-convergent pathways

Kaempferol-Phospholipid Complex: Formulation, and Evaluation of Improved Solubility, In Vivo Bioavailability, and Antioxidant Potential of Kaempferol

The current work describes the formulation and evaluation of a phospholipid complex of kaempferol toenhance the latter’s aqueous solubility, in vitro dissolution rate, in vivo antioxidant and hepatoprotectiveactivities, and oral bioavailability. The kaempferol-phospholipid complex was synthesized using a freeze-drying method with the formulation being optimized using a full factorial design (32) approach. The resultsinclude the validation of the mathematical model in order to ascertain the role of specific formulation andprocess variables that contribute favorably to the formulation’s development. The final product wascharacterized and confirmed by Differential Scanning Calorimetry (DSC), Fourier Transform InfraredSpectroscopy (FTIR), Proton Nuclear Magnetic Resonance Spectroscopy (1H-NMR), and Powder X-rayDiffraction (PXRD) analysis. The aqueous solubility and the in vitro dissolution rate were enhanced comparedto that of pure kaempferol. The in vivo antioxidant properties of the kaempferol-phospholipid complex wereevaluated by measuring its impact on carbon tetrachloride (CCl4)-intoxicated rats. The optimizedphospholipid complex improved the liver function test parameters to a significant level by restoration of allelevated liver marker enzymes in CCl4-intoxicated rats. The complex also enhanced the in vivo antioxidantpotential by increasing levels of GSH (reduced glutathione), SOD (superoxide dismutase), catalase anddecreasing lipid peroxidation, compared to that of pure kaempferol. The final optimized phospholipidcomplex also demonstrated a significant improvement in oral bioavailability demonstrated by improvementsto key pharmacokinetic parameters, compared to that of pure kaempferol

In- vitroantioxidant and anti-obesity properties of Bauhinia variegata

Bauhinia variegata L (Synonyms: Phanera variegata Benth), commonly known as orchid tree or Kachnar belongs to the family of Leguminosae and found throughout India. All parts of the plants are used in the treatment of many ailments such as obesity, dyspepsia, bronchitis, leprosy, ulcer etc. The objective of the present study was to assess the in- vitro antioxidant and anti-obesity properties of different solvent (hexane, chloroform, ethyl acetate, acetone, methanol and distilled water) extracts of Bauhinia variegataleaves. All the solvent extracts were found to contain different phytochemicals with bioactive properties at varying concentrations.The results of extraction showed that methanol was the suitable solvent for extraction of phytochemical as it recorded highest yield of 6.80%. The phytochemical assay results showed the highest polyphenol content in methanol extract (243 μg GAE/mg) and flavonoids content in chloroform extract (1.87 μg CE/g).The in-vitro antioxidant and anti obesity property was observed more in methanolic extract than the other extracts. The overall study suggests that Bauhinia variegataleaf extract could be a potential ingredient for the preparation of nutraceuticals to treat obesity and oxidative stress related complications.

Targeting groundwater potential zones using Electrical resistivity and GIS techniques in Kadavanar Sub-basin, South India

Geographical Information System techniques are widely used to determine suitable sites for groundwater recharge through artificial recharge techniques. The present research work is to identify suitable locations for constructing artificial recharge structures in the Kadavanar Sub-basin, South India. People in the Sub-basin mainly depend on the groundwater resources for drinking and irrigation purposes. Groundwater resources are often overexploited in many parts of this Sub-basin to meet the water demand leading to groundwater consumption. A lot of surfaces and sub-surface information and criteria are required for mapping the groundwater recharge zone. This is where the geographic information system [GIS] provides the right impetus besides the groundwater prospective zone to harness multilayered spatial data so that multi-criteria analysis is possible. This analysis integrates historic rainfall data analysis, groundwater level fluctuation, stream network, aquifer thickness, land use/land cover and basin slope. Drainage map, slope map and land use/land cover maps were prepared from satellite imageries. Vertical electrical sounding (VES) geophysical survey with Schlumberger electrode configuration was also conducted in the basin at 50 locations to map the aquifer thickness. Spatial variation maps for groundwater level and aquifer thickness were generated using GIS. Weighted aggregation method was used in this study to obtain groundwater recharge maps. Finally, multi-criteria analysis has been carried out to identify and assess the potential sites for groundwater recharge according to the associated weightages. It is established that GIS is best suited for the mapping of groundwater recharge zones. A similar study can be extended to any other hard-rock region facing water crises