Dendritic Cells In Vivo: A Key Target for a New Vaccine Science

Dendritic cells (DCs) are the antigen presenting cells that initiate and regulate immunity. By studying these cells in vivo, we will be able to move beyond standard approaches and design vaccines that directly harness the elaborate properties of DCs to control immunity

DC-SIGN: A guide to some mysteries of dendritic cells

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Research on human subjects in the JEM

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Decisions about dendritic cells: Past, present, and future

A properly functioning adaptive immune system signifies the best features of life. It is diverse beyond compare, tolerant without fail, and capable of behaving appropriately with a myriad of infections and other challenges. Dendritic cells are required to explain how this remarkable system is energized and directed. I frame this article in terms of the major decisions that my colleagues and I have made in dendritic cell science and some of the guiding themes at the time the decisions were made. As a result of progress worldwide, there is now evidence of a central role for dendritic cells in initiating antigen-specific immunity and tolerance. The in vivo distribution and development of a previously unrecognized white cell lineage is better understood, as is the importance of dendritic cell maturation to link innate and adaptive immunity in response to many stimuli. Our current focus is on antigen uptake receptors on dendritic cells. These receptors enable experiments involving selective targeting of antigens in situ and new approaches to vaccine design in preclinical and clinical systems

SnapShot: Dendritic cells

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The JEM and the JCB: a synergistic partnership

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Induction of interleukin lα mrna during the antigen-dependent interaction of sensitized t lymphoblasts with macrophages

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Accessory cell - T lymphocyte interactions: antigen dependent and independent clustering

Inaba, K., and Steinman, R.M. Accessory cell - T lymphocyte interactions: antigen dependent and independent clustering. J. Exp. Med. 163: 247-261, 1986https://digitalcommons.rockefeller.edu/historical-scientific-reports/1018/thumbnail.jp

Murine epidermal Langerhans cells mature into potent immunostimulatory dendritic cells in vitro

Schuler, G., and Steinman, R.M. Murine epidermal Langerhans cells mature into potent immunostimulatory dendritic cells in vitro. J. Exp. Med. 161: 526-546, 1985https://digitalcommons.rockefeller.edu/historical-scientific-reports/1016/thumbnail.jp