Unexplored capabilities of chemiluminescence and thermoanalytical methods in characterization of intact and degraded hyaluronans. Polym Degrad Stabil 91

Abstract Three intact and four degraded hyaluronans were investigated by using chemiluminometry, differential scanning calorimetry, and thermogravimetry. Degradation of hyaluronan was induced by a system containing H 2 O 2 alone (882 mM); 55 mM H 2 O 2 plus 1.25 mM CuCl 2 ; NaOCl alone (10 mM); and NaOCl plus CuCl 2 and ascorbic acid (10 mM, 0.1 mM, and 100 mM, respectively). The four different oxidative systems yielded biopolymer fragments represented by similar viscosity characteristics. The results obtained by using chemiluminescence and thermoanalytical methods indicate that hyaluronans of similar rheological properties could be distinguished from each other