CLME: An R Package for Linear Mixed Effects Models under Inequality Constraints

In many applications researchers are typically interested in testing for inequality constraints in the context of linear fixed effects and mixed effects models. Although there exists a large body of literature for performing statistical inference under inequality constraints, user friendly statistical software implementing such methods is lacking, especially in the context of linear fixed and mixed effects models. In this article we introduce CLME, a package in the R language that can be used for testing a broad collection of inequality constraints. It uses residual bootstrap based methodology which is reasonably robust to non-normality as well as heteroscedasticity. The package is illustrated using two data sets. The package also contains a graphical user interface built using the shiny package

Hernia into the umbilical cord with incarceration of liver and gall bladder in a newborn

AbstractIncarceration of liver tissue in a hernia of the umbilical cord is a rare occurrence. An incarceration of the gall bladder is even rarer. We report such a case in a newborn that had incarceration of both liver and gall bladder in to the umbilical cord

Anisotropy in the helicity modulus of a quantum 3D XY-model: application to YBCO

We present a variational study of the helicity moduli of an anisotropic quantum three-dimensional (3D) XY-model of YBCO in superconducting state. It is found that both the ab-plane and the c-axis helicity moduli, which are proportional to the inverse square of the corresponding magnetic field penetration depth, vary with temperature T as T to the fourth power in the zero temperature limit. Moreover, the c-axis helicity modulus drops with temperature much faster than the ab-plane helicity modulus because of the weaker Josephson couplings along the c-axis compared to those along the ab-plane. These findings are in disagreement with the experiments on high quality samples of YBCO.Comment: 9 pages, 1 figur

Collapse of a Bose gas: kinetic approach

We have analytically explored temperature dependence of critical number of particles for the collapse of a harmonically trapped attractively interacting Bose gas below the condensation point by introducing a kinetic approach within the Hartree-Fock approximation. The temperature dependence obtained by this easy approach is consisted with that obtained from the scaling theory.Comment: Brief Report, 4 pages, 1 figure, Accepted in Pramana-Journal of Physic

A Novel Role for ATM in Regulating Proteasome-Mediated Protein Degradation through Suppression of the ISG15 Conjugation Pathway

Ataxia Telangiectasia (A-T) is an inherited immunodeficiency disorder wherein mutation of the ATM kinase is responsible for the A-T pathogenesis. Although the precise role of ATM in A-T pathogenesis is still unclear, its function in responding to DNA damage has been well established. Here we demonstrate that in addition to its role in DNA repair, ATM also regulates proteasome-mediated protein turnover through suppression of the ISG15 pathway. This conclusion is based on three major pieces of evidence: First, we demonstrate that proteasome-mediated protein degradation is impaired in A-T cells. Second, we show that the reduced protein turnover is causally linked to the elevated expression of the ubiquitin-like protein ISG15 in A-T cells. Third, we show that expression of the ISG15 is elevated in A-T cells derived from various A-T patients, as well as in brain tissues derived from the ATM knockout mice and A-T patients, suggesting that ATM negatively regulates the ISG15 pathway. Our current findings suggest for the first time that proteasome-mediated protein degradation is impaired in A-T cells due to elevated expression of the ISG15 conjugation pathway, which could contribute to progressive neurodegeneration in A-T patients

Generation of dark pulses in a bismuth tellurite based mode-locked erbium-doped fiber laser

We report on the formation of dark pulses in a highly nonlinear fiber laser passively mode-locked by a Bistmuth Tellurite (Bi2Te3) based SA. The SA was fabricated by embedding Bi2Te3 powder into polyvinyl alcohol (PVA) film by a solution casting technique. By inserting the SA into an EDFL cavity, stable mode-locked operation was achieved at 1592.68 nm with the maximum pulse energy up to 2.38 nJ by adjusting polarization controller. The laser operated at pulse repetition frequency of 1.0 MHz with a pulse width of 215 ns. These results suggested that Bi2Te3 could be developed as an effective SA for mode-locked dark pulses generation in a highly nonlinear cavity

Rice breeding for low input agriculture

A low-input-based farming system can reduce the adverse effects of modern agriculture through proper utilization of natural resources. Modern varieties often need to improve in low-input settings since they are not adapted to these systems. In addition, rice is one of the most widely cultivated crops worldwide. Enhancing rice performance under a low input system will significantly reduce the environmental concerns related to rice cultivation. Traits that help rice to maintain yield performance under minimum inputs like seedling vigor, appropriate root architecture for nutrient use efficiency should be incorporated into varieties for low input systems through integrated breeding approaches. Genes or QTLs controlling nutrient uptake, nutrient assimilation, nutrient remobilization, and root morphology need to be properly incorporated into the rice breeding pipeline. Also, genes/QTLs controlling suitable rice cultivars for sustainable farming. Since several variables influence performance under low input conditions, conventional breeding techniques make it challenging to work on many traits. However, recent advances in omics technologies have created enormous opportunities for rapidly improving multiple characteristics. This review highlights current research on features pertinent to low-input agriculture and provides an overview of alternative genomics-based breeding strategies for enhancing genetic gain in rice suitable for low-input farming practices

Finite temperature scaling theory for the collapse of Bose-Einstein condensate

We show how to apply the scaling theory in an inhomogeneous system like harmonically trapped Bose condensate at finite temperatures. We calculate the temperature dependence of the critical number of particles by a scaling theory within the Hartree-Fock approximation and find that there is a dramatic increase in the critical number of particles as the condensation point is approached.Comment: Published online [6 pages, 3 figures

Casimir force on interacting Bose-Einstein condensate

We have presented an analytic theory for the Casimir force on a Bose-Einstein condensate (BEC) which is confined between two parallel plates. We have considered Dirichlet boundary conditions for the condensate wave function as well as for the phonon field. We have shown that, the condensate wave function (which obeys the Gross-Pitaevskii equation) is responsible for the mean field part of Casimir force, which usually dominates over the quantum (fluctuations) part of the Casimir force.Comment: Accepted in Journal of Physics B: Atomic, Molecular and Optical Physic