Salvinorin A analogues PR-37 and PR-38 attenuate compound 48/80-induced itch responses in mice: Salvinorin A analogues PR-37 and PR-38 in pruritus

The opioid system plays a crucial role in several physiological processes in the CNS and in the periphery. It has also been shown that selective opioid receptor agonists exert potent inhibitory action on pruritus and pain. In this study we examined whether two analogues of Salvinorin A, PR-37 and PR-38, exhibit antipruritic properties in mice

Using Tree Ensembles to Analyze National Baseball Hall of Fame Voting Patterns: An Application to Discrimination in BBWAA Voting

We predict the induction of Major League Baseball hitters and pitchers into the National Baseball Hall of Fame by the Baseball Writers Association of America. We employ a Random Forest algorithm for binary classification, improving upon past models with a simplistic input approach. Our results suggest that the random forest technique is a fruitful line of research with prediction in the sports world. We find an error rate as low as 0.91% in our most accurate forest, with no out-of-bag Error higher than 2.6% in any tree ensemble. We extend the results to an examination of the possibility of discrimination with respect to BBWAA voting, finding little evidence for exclusions based on race.