Effect of Tannin and Plant Tannins on some Organs and Physic-Chemical Characters of Diabetic Wistar Rats

A seven weeks feeding trial was carried out to investigate the effect of 1% tannin, 5% tannin, 1.1% tannin in gum of Neem (Azadirachta indica) and 3.3 % tannin in pod of okra (Abelmoschus esculentus) on lipid profile, glucose, protein and body weight of diabetic rats, in addition the histological change in liver and kidney of experimental rats was studied. The rats were randomly assigned to five groups which are orally consumption different concentration of tannin. Group number 1, 2, 3, 4 and 5 were received 0.0 (control), 1.0, 1.1, 3.3 and 5 % tannin, respectively. Results shown significant reduction in cholesterol, HDL, LDL, triglyceride, glucose level at p≤ 0.05, but there was slight reduction in body weight and no significant change in protein level. Group number 5 (received 5 % tannin) in which all rats were death within the first week. This result was indicated 5 % tannin is unsafe dose for the rats, but all treated rats was continued the experiment until seven weeks without abnormal clinical signs. These findings are indicated 1, 1.1, and 3.3 % tannin were safe dose for tannin. Results in histological study showed liver and kidney tissues were not affected by different concentration of tannin except 5% tannin which affected on tissues of kidney