33 research outputs found
Les relations géomorpho-pédologiques de la retombée nord-occidentale du massif guyanais (Venezuela) : 2ème partie. Les unités géomorpho-pédologiques
Artificially decreasing cortical tension generates aneuploidy in mouse oocytes
Human and mouse oocytes’ developmental potential can be predicted by their mechanical
properties. Their development into blastocysts requires a specific stiffness window. In this
study, we combine live-cell and computational imaging, laser ablation, and biophysical
measurements to investigate how deregulation of cortex tension in the oocyte contributes to
early developmental failure. We focus on extra-soft cells, the most common defect in a
natural population. Using two independent tools to artificially decrease cortical tension, we
show that chromosome alignment is impaired in extra-soft mouse oocytes, despite normal
spindle morphogenesis and dynamics, inducing aneuploidy. The main cause is a cytoplasmic
increase in myosin-II activity that could sterically hinder chromosome capture. We describe
here an original mode of generation of aneuploidies that could be very common in oocytes
and could contribute to the high aneuploidy rate observed during female meiosis, a leading
cause of infertility and congenital disorders
Les relations géomorpho-pédologiques de la retombée nord-occidentale du massif guyanais (Venezuela) : 2ème partie. Les unités géomorpho-pédologiques
Etude de sols bruns formés sur arènes granitiques de la bordure septentrionale de la Sierra de Prades (Tarragone, Espagne)
Macroscopic electrostatic effects in the ATR-FTIR spectrum of modern and archeological bones. Macroscopic electrostatic effects in ATR-FTIR spectra of modern and archaeological bones
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