Fluconazole and boric acid for treatment of vaginal candidiasis- New words about old issue

Objective: To compare boric acid as an effective treatment for VVC  compared to fluconazole. We also studied the efficiency of these drugs in preventing recurrence of VVC.Design: A cross sectional, randomized, double-blind study.Settings: Gynaecology clinic of Imam Reza hospital, Tehran - IranSubjects: Women with signs and symptoms related to Vulvo Vaginal Candidiasis.Results: Seventy five patients out of total 150 patients with signs and symptoms related to Vulvo Vaginal Candidiasis were treated with boric acid powder every night for a week and the remaining 75 patients received Fluconazole. The cure rate in first group was 46.7% but the cure rate in second group was 37.3%. The difference was not statistically significant (P>0.3). Difference between the efficacy of the two drugs was not  significant either (P=0.47). The recurrence rate among patients in first group was 35% while it was 32% in second group. Their difference was not statistically significant (P=0.54).Conclusion: According to our findings, treatment of vaginal candidiasis with boric acid is as effective as fluconazole. The availability of boric acid and its relatively low cost suggests it as a safe and effective drug for treatment of candidiasis

Papillon-lefèvre syndrome: A case report

Takayasu's arteritis (TA) is a major chronic vasculitis disorder that its etiology is unknown. Patients are mostly Asian women who often show nonspecific symptoms such as fever, myalgia, arthralgia, weight loss, and anemia. The report relates to a 17-year-old girl suffering from complaints, permanent and uncontinental pain starting from a month earlier, with loss of appetite and weight loss (4 kg), and night sweats. She had no diarrhea or gastrointestinal symptoms but had a pain in the shoulder and chest area since the last 5 months. She got better after seeing a physician and receiving supplements. She had a history of pain in the ear from the last five months leading to otitis, and was treated as a case of brucellosis with a score of 1.20 in the Coombs Wright test. According to the physical examination findings, the patient's left, radial, ulnar, and proximal pulses, and blood pressure were unexplained, and in the supraclavicular region of the left and the umbilical region, bruit was heard and the shape of the left nail was changed. Laboratory tests and imaging were performed for the patient, and after angiography, the left subclavian artery stenosis was detected. Given the age and sex of the patient and the results obtained, she was diagnosed with Takayasu's arteritis. © 2021, Kerman University of Medical Sciences. All rights reserved

Detection of tooth decay: Report of a novel invention

Tooth decay is a microbial infectious disease that caused to local damage of calcification tissues of tooth and common cause of tooth damage in youth. Therefore, prevention of this damage is necessary. One of the most important methods of prevention of tooth decay is opportune diagnosis of decay and reconstruction. The present study aimed to introduce a novel invention for early diagnosis of tooth decay and to compare result of experiment of this device with other common methods. This device will diagnose tooth decay without any chemicals and rays such as lasers or X-rays. It works by shining infrared light reflected on the surface of the tooth. It will be placed on the tooth and Transmitting infrared light will be reflected on the surface of the tooth and Infrared sensor receives light from the tooth surface. All lights are reflected, but if the tooth was rotten, then its color would be darker and the reflected light would be absorbed on the surface of the teeth. The rest of the light is reflected. By the difference between the amount of light reflected from the surface of decayed teeth and Healthy Teeth the device is able to detect decay and dental health. Infrared sensor is a type of optical transistors. When the light is shone on them, the light will be converted into an electric current. This electric current will be changed in different expressions. The microcontroller device will process these flows. The phase logic is used for data processing that substantially increases its accuracy. The invented device does not use chemicals to detect caries which is quite safe and affordable. Comparison the result of diagnosis of damaged tooth using this device with diagnoses of two independent dentists indicated more accuracy, efficiency and confidential (p < 0.01). The invented device can be used as the primary method of dental caries

In vitro Osteogenic impulse effect of Dexamethasone on periodontal ligament stem cells

Periodontium is a complex organ composed of mineralized epithelial and connective tissue. Dexamethasone could stimulate proliferation of osteoblast and fibroblasts. This study aimed to assess the osteogenic effect of dexamethasone on periodental ligament (PDL) stem cells. PDL stem cells were collected from periodontal ligament tissue of root of extracted premolar of young and healthy people. The stem cells were cultured in alpha-MEM Medium in three groups, one group with basic medium contains (alpha-MEM and FBS 10 and 50 mmol of beta gelisrophosphat and L ascorbic acid mu g/ml), the second group: basic medium with dexamethasone and the third one: basic medium without any osteogenic stimulant. Mineralization of cellular layer was analyzed with Alizarin red stain method. Osteogenic analysis was done by Alkaline phosphates and calcium test. These analysis indicated that the amount of intra-cellular calcium and alkaline phosphates in the Dexamethasone group was far more than the control and basic group (P<0.05). The results of Alizarin red stain indicated more mineralization of cultured cells in Dexamethasone group (P<0.05). The study results showed that Dexamethasone has significant osteogenic effect on PDL stem cells and further studies are recommended to evaluate its effect on treatment of bone disorders

Analyzing the osteogenic stimulatory effect of the combination dexamethasone and low levelled laser irradiation(L.L.L.I) on periodontal ligament stem cell(PDLSc)

The periodontium is a supportive structure which surrounds the teeth and supports them. This structure consists of different tissues including gingiva, cementum, periodontal ligament and alveolar bone. The aim of this study is to analyze the osteogenic stimulatory effect of the combination of dexamethasone and L.L.L.I. on the periodontal stem cell (PDLSc). The PDLSc were obtained from the first premolar root of young healthy patients who had their teeth extracted for orthodontic treatment purposes. After obtaining the stem cells, the PDLSc were cultured in plates containing α-MEM and 15 FBS. The osteogenic differentiation was carried out in three groups, basic medium, Dexamethasone and L.L.L.I. and negative control and then the alizarin red staining test, calcium test and alkaline phosphatase test were performed. The results showed that intracellular calcium and alkaline phosphatase in the dexamethasone and L.L.L.I. group was significantly higher than the control group (p<0.05). Also the stain test showed mineralization of cells in the dexamethasone and L.L.L.I. group. The results of this study showed that the combination of dexamethasone and L.L.L.I. has a stimulatory osteogenic effect on PDLSc