The utility of the 3D imaging software in the macroscopic rendering of complex gynecologic specimens

A new generation of three dimensional (3D) imaging software for the anatomical rendering of the human body, and related surgical pathologies, is postulated. Its practical application is underlined

Comparing Skill Acquisition Under Varying Onsets of Differential Reinforcement: A Preliminary Analysis

The purpose of the current study was to evaluate the effect of implementing differential reinforcement at different times relative to the onset of teaching new skills to learners with autism spectrum disorder. Specifically, we first determined the most efficient differential reinforcement arrangement for each participant. Using the most efficient arrangement, we evaluated if differential reinforcement from the immediate onset, early onset, or late onset is the most efficient for learners to acquire a new skill. Three children diagnosed with autism spectrum disorder who have a history of receiving intervention based on the principles of applied behavior analysis participated in this study. The immediate onset of differential reinforcement resulted in the most efficient instruction in 6 of 7 comparisons. The results are discussed in light of previous studies and suggestions for future research are provided

Lethal cardiotoxicity from quaternary ammonium compounds contained in an unguarded household detergent at a psychiatric facility

Here, referred for the first time in literature, we present the forensic case of death, with suicidal intent, following ingestion of a conspicuous amount of quaternary ammonium compounds contained in an unguarded bottle of household detergent. The deceased person was a young female patient at a psychiatric facility; the cause of death was acute heart failure due to spotty infiltration of neutrophils, lymphocytes and plasma cells in the myocardial tissue, observable in the course of toxic myocarditis. The dominant pathogenetic factors involved are direct damage of myocardial cells and a superimposed immune response extending to the epicardial perivascular spaces. This rare form of acute myocarditis has never been previously described. Moreover, this fatal event emphasizes the need for planned clinical risk-management measures and for guidelines to prevent future adverse events of this kind in psychiatric facilities

An oral hygiene instruction program for orthodontic patients

Introduction. Protocols which contribute to the long-term success of orthodontic treatment, in both adult and young patients, and which establish a proper routine for oral hygiene at home, must be personalized and followed strictly. Materials and methods. Our protocol includes the following steps: before orthodontic treatment (initial examination, initial preparation and reassessment); during orthodontic treatment (first session, treatment session in association with oral hygiene check-ups, recall, if oral hygiene is insufficient); after orthodontic treatment (postreatment support). The differences in treatment and approach necessary when dealing with adults or children and with removable appliance or fixed appliance are also highlighted

Estrogen receptor alpha overexpression in multinucleate cell angiohistiocytoma: new insights into the pathogenesis of a reactive process

Multinucleate cell angiohistiocytoma (MCAH) is a putative reactive skin lesion, which has been reported mostly in adult female patients, and hormones have been recently suggested as a factor influencing its development. To test this hypothesis, monoclonal anti-estrogen receptor (ER) a, anti-progesterone receptor (PR), anti-Factor XIIIa, and polyclonal anti-vascular endothelial growth factor (VEGF) antibodies were applied by immunohistochemistry on a series of 21 MCAHs and, compared to 10 cases of dermatofibroma (DF) and 5 cases of chronic dermatitis presenting multinucleate cells. On normal skin surrounding the lesions and in cases of DF and chronic dermatitis, ERa was expressed in few undifferentiated and differentiated sebocytes, in few cells of anagen follicles and perifollicular mesenchymal cells, and in scattered dermal fibrocytes. In MCAHs, ERa was strongly expressed in interstitial spindle cells, spindle cells surrounding the characteristic vascular component of the lesion, and rare multinucleate cells. PR expression was restricted to sparse spindle cells and few sebocytes, whereas Factor XIIIa stained spindle cells in the dermis of normal and inflamed skin and in both MCAH and DF, and VEGF staining resulted completely negative. ERα, PR, and VEGF have been reported as poorly expressed in normal skin. In the present study, expression of ERα resulted upregulated in cases of MCAH, particularly in spindle cells, compared with that in DF cases. These findings underline the pathogenetic difference between MCAH and DF and also corroborate the suggested hypothesis of a role played by hormones, mainly ERα, in the development of this lesion. These observations could open a new strategy in the treatment of MCAH by antiestrogen therapy

Casa in linea

Progetto di edificio residenziale in linea a basso costo-alta prestazion