The effect of elevated hydrostatic pressure on the spectral absorption of deep-sea fish visual pigments

The effect of hydrostatic pressure (0.1-54 MPa, equivalent to pressures experienced by fish from the ocean's surface to depths of ca. 5400 m) on visual pigment absorption spectra was investigated for rod visual pigments extracted from the retinae of 12 species of deep-sea fish of diverse phylogeny and habitat. The wavelength of peak absorption (λmax) was shifted to longer wavelengths by an average of 1.35 nm at 40 MPa (a pressure approximately equivalent to average ocean depth) relative to measurements made at one atmosphere (ca. 0.1 MPa), but with little evidence of a change in absorbance at the λmax. We conclude that previousλ max measurements of deep-sea fish visual pigments, made at a pressure close to 0.1 MPa, provide a good indication ofλ max values at higher pressures when considering the ecology of vision in the deep-sea. Although not affecting the spectral sensitivity of the animal to any important degree, the observed shift inλ max may be of interest in the context of understanding opsin-chromophore interaction and spectral tuning of visual pigments

Fatigue delamination behaviour of unidirectional carbon fibre/epoxy laminates reinforced by Z-Fiber® pinnin

-Pin reinforced carbon-fibre epoxy laminates were tested under Mode I and Mode II conditions, both quasi-statically and in fatigue. Test procedures were adapted from existing standard or pre-standard tests. Samples containing 2% and 4% areal densities of carbon-fibre Z-pins (0.28mm diameter) were compared with unpinned laminates. Quasi-static tests under displacement control yielded a dramatic increase of the apparent delamination resistance. Specimens with 2% pin density failed in Mode I at loads 170N, equivalent to an apparent GIC of 2kJ/m2. Fatigue testing under load control showed that the presence of the through- thickness reinforcement slowed down fatigue delamination propagation

The clinical application of PET/CT: a contemporary review

The combination of positron emission tomography (PET) scanners and x-ray computed tomography (CT) scanners into a single PET/CT scanner has resulted in vast improvements in the diagnosis of disease, particularly in the field of oncology. A decade on from the publication of the details of the first PET/CT scanner, we review the technology and applications of the modality. We examine the design aspects of combining two different imaging types into a single scanner, and the artefacts produced such as attenuation correction, motion and CT truncation artefacts. The article also provides a discussion and literature review of the applications of PET/CT to date, covering detection of tumours, radiotherapy treatment planning, patient management, and applications external to the field of oncology

Deformation of a Trapped Fermi Gas with Unequal Spin Populations

The real-space densities of a polarized strongly-interacting two-component Fermi gas of $^6$Li atoms reveal two low temperature regimes, both with a fully-paired core. At the lowest temperatures, the unpolarized core deforms with increasing polarization. Sharp boundaries between the core and the excess unpaired atoms are consistent with a phase separation driven by a first-order phase transition. In contrast, at higher temperatures the core does not deform but remains unpolarized up to a critical polarization. The boundaries are not sharp in this case, indicating a partially-polarized shell between the core and the unpaired atoms. The temperature dependence is consistent with a tricritical point in the phase diagram.Comment: Accepted for publication in Physical Review Letter

Production of TGF-alpha and TGF-beta by cultured keratinocytes, skin and oral squamous cell carcinomas--potential autocrine regulation of normal and malignant epithelial cell proliferation.

Transforming growth factors have a wide range of biological activities related to cell proliferation and differentiation. In general TGF-alpha promotes cell proliferation while TGF-beta may stimulate or inhibit proliferation depending on the cell type and growth factor environment. Cultured human keratinocytes, skin and oral squamous cell carcinomas were analysed for the presence of transcripts and protein for the transforming growth factors alpha & beta. Both growth factors were detected in cultured keratinocytes (which have receptors for and respond to both ligands), and in medium conditioned by these cells. Additionally transcripts for TGF-alpha were found preferentially in the basal, proliferative compartment of cultured keratinocytes. Similarly both growth factors were detected in oral squamous cell carcinomas and a highly significant inverse correlation was found between the levels of TGF-alpha and the epidermal growth factor receptor in these tumours. The data for TGF-alpha are consistent with the existence of an autocrine growth control loop influencing cell proliferation in both a normal cell type and malignant epithelial tissues, a process that in keratinocytes and responsive squamous cell carcinomas could be modulated by TGF-beta

The Bayesian Decision Tree Technique with a Sweeping Strategy

The uncertainty of classification outcomes is of crucial importance for many safety critical applications including, for example, medical diagnostics. In such applications the uncertainty of classification can be reliably estimated within a Bayesian model averaging technique that allows the use of prior information. Decision Tree (DT) classification models used within such a technique gives experts additional information by making this classification scheme observable. The use of the Markov Chain Monte Carlo (MCMC) methodology of stochastic sampling makes the Bayesian DT technique feasible to perform. However, in practice, the MCMC technique may become stuck in a particular DT which is far away from a region with a maximal posterior. Sampling such DTs causes bias in the posterior estimates, and as a result the evaluation of classification uncertainty may be incorrect. In a particular case, the negative effect of such sampling may be reduced by giving additional prior information on the shape of DTs. In this paper we describe a new approach based on sweeping the DTs without additional priors on the favorite shape of DTs. The performances of Bayesian DT techniques with the standard and sweeping strategies are compared on a synthetic data as well as on real datasets. Quantitatively evaluating the uncertainty in terms of entropy of class posterior probabilities, we found that the sweeping strategy is superior to the standard strategy

Faint Radio Sources and Star Formation History

Faint extragalactic radio sources provide important information about the global history of star formation. Sensitive radio observations of the Hubble Deep Field and other fields have found that sub-mJy radio sources are predominantly associated with star formation activity rather than AGN. Radio observations of star forming galaxies have the advantage of being independent of extinction by dust. We use the FIR-radio correlation to compare the radio and FIR backgrounds, and make several conclusions about the star forming galaxies producing the FIR background. We then use the redshift distribution of faint radio sources to determine the evolution of the radio luminosity function, and thus estimate the star formation density as a function of redshift.Comment: 12 pages, 9 figures, latex using texas.sty, to appear in the CD-ROM Proceedings of the 19th Texas Symposium on Relativistic Astrophysics and Cosmology, held in Paris, France, Dec. 14-18, 1998. Eds.: J. Paul, T. Montmerle, and E. Aubourg (CEA Saclay). No changes to paper, just updated publication info in this commen

Planck Observations of M33

We have performed a comprehensive investigation of the global integrated flux density of M33 from radio to ultraviolet wavelengths, finding that the data between $\sim$100 GHz and 3 THz are accurately described by a single modified blackbody curve with a dust temperature of $T_\mathrm{dust}$ = 21.67$\pm$0.30 K and an effective dust emissivity index of $\beta_\mathrm{eff}$ = 1.35$\pm$0.10, with no indication of an excess of emission at millimeter/sub-millimeter wavelengths. However, sub-dividing M33 into three radial annuli, we found that the global emission curve is highly degenerate with the constituent curves representing the sub-regions of M33. We also found gradients in $T_\mathrm{dust}$ and $\beta_\mathrm{eff}$ across the disk of M33, with both quantities decreasing with increasing radius. Comparing the M33 dust emissivity with that of other Local Group members, we find that M33 resembles the Magellanic Clouds rather than the larger galaxies, i.e., the Milky Way and M31. In the Local Group sample, we find a clear correlation between global dust emissivity and metallicity, with dust emissivity increasing with metallicity. A major aspect of this analysis is the investigation into the impact of fluctuations in the Cosmic Microwave Background (CMB) on the integrated flux density spectrum of M33. We found that failing to account for these CMB fluctuations would result in a significant over-estimate of $T_\mathrm{dust}$ by $\sim$5 K and an under-estimate of $\beta_\mathrm{eff}$ by $\sim$0.4.Comment: Accepted for publication in MNRA

Absolute Calibration of the Radio Astronomy Flux Density Scale at 22 to 43 GHz Using Planck

The Planck mission detected thousands of extragalactic radio sources at frequencies from 28 to 857 GHz. Planck's calibration is absolute (in the sense that it is based on the satellite's annual motion around the Sun and the temperature of the cosmic microwave background), and its beams are well characterized at sub-percent levels. Thus Planck's flux density measurements of compact sources are absolute in the same sense. We have made coordinated VLA and ATCA observations of 65 strong, unresolved Planck sources in order to transfer Planck's calibration to ground-based instruments at 22, 28, and 43 GHz. The results are compared to microwave flux density scales currently based on planetary observations. Despite the scatter introduced by the variability of many of the sources, the flux density scales are determined to 1-2% accuracy. At 28 GHz, the flux density scale used by the VLA runs 3.6% +- 1.0% below Planck values; at 43 GHz, the discrepancy increases to 6.2% +- 1.4% for both ATCA and the VLA.Comment: 16 pages, 4 figures and 4 table