Cooperative core competencies in tourism: Combining resource-based and relational approaches in destination governance

Community-based tourist destinations can be understood as networks of tourism service providers, which need to combine their resources and competencies to generate the overall holiday experience. Building on strategic management theories, the study aims at exploring the relationship between the destinations management’s reflexive capabilities and the cooperative core competencies of a tourist destination. By means of reflexive capabilities, destination management is suggested to be able to induce a high level of network quality, which in turn may be a pre-condition for the interlacing of the service providers’ competencies and resources, i.e. for the development of cooperative core competencies. Based on a quantitative survey in Bavaria, the results support these assumptions and indicate that reflexive capabilities may promote the development of cooperative core competencies in tourist destinations. The paper advances tourism literature by introducing, operationalizing and testing the idea of cooperative core competencies in the context of tourist destinations

On the fate of singularities and horizons in higher derivative gravity

We study static spherically symmetric solutions of high derivative gravity theories, with 4, 6, 8 and even 10 derivatives. Except for isolated points in the space of theories with more than 4 derivatives, only solutions that are nonsingular near the origin are found. But these solutions cannot smooth out the Schwarzschild singularity without the appearance of a second horizon. This conundrum, and the possibility of singularities at finite r, leads us to study numerical solutions of theories truncated at four derivatives. Rather than two horizons we are led to the suggestion that the original horizon is replaced by a rapid nonsingular transition from weak to strong gravity. We also consider this possibility for the de Sitter horizon.Comment: 15 pages, 3 figures, improvements and references added, to appear in PR

Extended Gravity Theories and the Einstein-Hilbert Action

I discuss the relation between arbitrarily high-order theories of gravity and scalar-tensor gravity at the level of the field equations and the action. I show that $(2n+4)$-order gravity is dynamically equivalent to Brans-Dicke gravity with an interaction potential for the Brans-Dicke field and $n$ further scalar fields. This scalar-tensor action is then conformally equivalent to the Einstein-Hilbert action with $n+1$ scalar fields. This clarifies the nature and extent of the conformal equivalence between extended gravity theories and general relativity with many scalar fields.Comment: 12 pages, Plain Latex, SUSSEX-AST-93/7-

Energy in Generic Higher Curvature Gravity Theories

We define and compute the energy of higher curvature gravity theories in arbitrary dimensions. Generically, these theories admit constant curvature vacua (even in the absence of an explicit cosmological constant), and asymptotically constant curvature solutions with non-trivial energy properties. For concreteness, we study quadratic curvature models in detail. Among them, the one whose action is the square of the traceless Ricci tensor always has zero energy, unlike conformal (Weyl) gravity. We also study the string-inspired Einstein-Gauss-Bonnet model and show that both its flat and Anti-de-Sitter vacua are stable.Comment: 18 pages, typos corrected, one footnote added, to appear in Phys. Rev.

Circulating MicroRNA Levels Indicate Platelet and Leukocyte Activation in Endotoxemia Despite Platelet P2Y12 Inhibition

There is evidence for the effects of platelet inhibition on innate immune activation. Circulating microRNAs (miRNAs) have been implicated as markers of platelet and leukocyte activation. In the present study, we assessed the effects of P2Y12 inhibitors on platelet and leukocyte miRNAs during endotoxemia. Healthy volunteers were randomly assigned to receive oral ticagrelor (n = 10), clopidogrel (n = 8) or no drug (n = 8) for one week, followed by an intravenous bolus of 2 ng/kg endotoxin. Serum was collected at baseline, after one week of antiplatelet treatment and 6 and 24 h after endotoxin administration. MiRNAs were screened using LNA-based qPCR, followed by TaqMan-qPCR validation of candidates. Clinical validation was performed in 41 sepsis patients. Platelet-enriched miR-197, miR-223 and miR-223* were decreased in volunteers following antiplatelet therapy. Endotoxin increased platelet miRNAs, whilst the opposite effect was seen for leukocyte-enriched miR-150. Neither of these endotoxin-mediated effects were altered by P2Y12 inhibitors. Sepsis patients with fatal outcomes (n = 12) had reduced miR-150 levels compared with survivors (n = 29). In conclusion, we show that miR-150 is downregulated in experimental endotoxemia and can predict survival in sepsis but is unaffected by P2Y12 inhibition. While P2Y12 inhibition reduces platelet-associated miRNAs in healthy volunteers, it fails to attenuate the response of platelet miRNAs to endotoxemia

Hospitality entrepreneurs managing quality of life and business growth

The hospitality industry is dominated by small- and medium-sized enterprises (SMEs).They are often led by entrepreneurs who face the challenge of simultaneously managing business decisions and their own wellbeing. The competitiveness of tourism destinations often depends on these entrepreneurs and therefore understanding their motivations and work patterns is critical. Research on individual wellbeing increasingly builds on the concept of quality of life (QoL). Hospitality and tourism literature so far predominantly focused on investigating QoL for tourists and residents, rather than for entrepreneurs’ QoL, even though being key stakeholders in the hospitality industry. Therefore, this study explores the factors influencing hospitality entrepreneurs’ quality of life (“HE-QoL”) and how these relate to business growth. Results of a 380 hospitality entrepreneurs’ survey identify six distinct factors of HE-QoL. Two groups of HE-QoL are identified with significant differences in fitness level activity, entrepreneurial competencies and business growth. Findings lead to recommendations to reduce stress to improve HE-QoL, and to develop entrepreneurial competencies, which help to cope with entrepreneurial challenges. Tourism destinations and politics can support hospitality entrepreneurs in these actions by creating conditions that foster social exchange in regional communities and trust in political and economic stability

Inhibition of profibrotic microRNA-21 affects platelets and their releasate.

Fibrosis is a major contributor to organ disease for which no specific therapy is available. MicroRNA-21 (miR-21) has been implicated in the fibrogenetic response, and inhibitors of miR-21 are currently undergoing clinical trials. Here, we explore how miR-21 inhibition may attenuate fibrosis using a proteomics approach. Transfection of miR-21 mimic or inhibitor in murine cardiac fibroblasts revealed limited effects on extracellular matrix (ECM) protein secretion. Similarly, miR-21-null mouse hearts showed an unaltered ECM composition. Thus, we searched for additional explanations as to how miR-21 might regulate fibrosis. In plasma samples from the community-based Bruneck Study, we found a marked correlation of miR-21 levels with several platelet-derived profibrotic factors, including TGF-β1. Pharmacological miR-21 inhibition with an antagomiR reduced the platelet release of TGF-β1 in mice. Mechanistically, Wiskott-Aldrich syndrome protein, a negative regulator of platelet TGF-β1 secretion, was identified as a direct target of miR-21. miR-21-null mice had lower platelet and leukocyte counts compared with littermate controls but higher megakaryocyte numbers in the bone marrow. Thus, to our knowledge this study reports a previously unrecognized effect of miR-21 inhibition on platelets. The effect of antagomiR-21 treatment on platelet TGF-β1 release, in particular, may contribute to the antifibrotic effects of miR-21 inhibitors

A model of collaborative innovation between local government and tourism operators

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‘Kamikaze’ heritage tourism in Japan: A pathway to peace and understanding?

Reflecting the wider belief that international tourism offers the opportunity to encourage peace and understanding amongst peoples and nations, one objective of Japan’s recent tourism development policy is the enhancement of mutual understanding and the promotion of international peace. The purpose of this paper is to consider the extent to which this objective is achievable, particularly in the context of continuing controversy surrounding the country’s confrontation of its twentieth century military heritage in general and its role in the Pacific War in particular. Based on research at two ‘difficult’ heritage sites, Chiran Peace Museum in Kagoshima Prefecture and Yūshūkan War Museum in Tokyo, it explores specifically how the kamikaze phenomenon is commemorated and interpreted for international visitors, in so doing revealing a significant degree of dissonance at both sites. Not only is a selective narrative of heroic sacrifice presented within a wider revisionist history of the Pacific War but also no attempt is made to acknowledge the prevailing cultural context that might underpin a more nuanced understanding of the kamikaze. Hence, the paper concludes that a meaningful opportunity to enhance international understanding has been missed