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A configurable analog VLSI neural network with spiking neurons and self-regulating plastic synapse

PREDICTORS OF BRONCHOPULMONARY DYSPLASIA (BPD) IN A LOW BPD SETTING:A 6-YEAR POPULATION-BASED COHORT OF THE MARCHE REGION

8reservedmixedPalazzi, Ml; Pannunzi, Cp; Pasqualini, M; Rondina, C; Burattini, I; D'Ascenzo, R; Cogo, P; Carnielli, VpPalazzi, Ml; Pannunzi, Cp; Pasqualini, M; Rondina, C; Burattini, I; D'Ascenzo, R; Cogo, Paola; Carnielli, V

Finasteride and rofecoxib combination in the treatment of benign prostatic hyperplasia (BPH)

Inflammation is frequently associated with human benign prostatic hyperplasia (BPH) and may concur in the development of urinary obstruction.Cyclooxygenase-2 (COX-2) is an inducible pro-inflammatory enzyme. COX-2 is expressed in prostate tissue, including BPH, and it may stimulate prostate growth by its ability to increase prostaglandin synthesis, promote angiogenesis and inhibit apoptosis. The aim of the study was to analyze whether combination therapy with rofecoxib, a COX-2 inhibitor, and finasteride, an inhibitor of prostatic 5alfa-reductase, offers an advantage compared to finasteride monotherapy in patients with symptomatic BPH

The IGF axis in prostate cancer

Prostate cancer, the most frequent non-cutaneous malignancy in men from industrialized countries, is a growing medical problem, representing the second leading cause of male cancer deaths. In the last decade, converging evidence from epidemiological and biological studies suggests that the Insulin-like Growth Factor (IGF) axis is involved in the tumorigenesis and neoplastic growth of prostate cancer. Epidemiological observations indicated that circulating IGF-I levels are positively associated with the increased risk of prostate cancer. The activation of type I IGF receptor (IGF-IR) by IGFI and/or IGF-II, has mitogenic and antiapoptotic effects on normal and malignant prostate cells. Altered expression of IGF axis components has also been reported in vitro and in animal models of prostate cancer, as well as in human prostate cancer tissue samples. In this review we address and analyze epidemiological studies, in vitro and in vivo cancer models, and human ex vivo prostate cancer researches performed to date supporting the role of IGF axis in prostate cancer. © 2007 Bentham Science Publishers Ltd