Breastfeeding and motor development: A longitudinal cohort study

Background: While there is a large body of work supporting the importance of early feeding practices on cognitive, immunity, behavioural and mental outcomes, few longitudinal studies have focused on motor development. The relationship between duration of breast feeding and motor development outcomes at 10, 14, and 17 years were examined. Methods: Data were obtained from the Western Australian Pregnancy (Raine) Study. There were 2868 live births recorded and children were examined for motor proficiency at 10 (M = 10.54, SD = 2.27), 14 (M = 14.02, SD = 2.33) and 17 (M = 16.99, SD = 2.97) years using the McCarron Assessment of Neuromuscular Development (MAND). Using linear mixed models, adjusted for covariates known to affect motor development, the influence of predominant breast feeding for⩾6 months on motor development outcomes was examined. Results: Breast feeding for ⩾6 months was positively associated with improved motor development outcomes at 10, 14 and 17 years of age (p = 0.019, β 1.38) when adjusted for child’s sex, maternal age, alcohol intake, family income, hypertensive status, gestational stress and mode of delivery. Conclusion: Early life feeding practices have an influence on motor development outcomes into late childhood and adolescence independent of sociodemographic factors. Abbreviations: MAND, McCarron Assessment of Neuromuscular Development; NDI, Neuromuscular Development Index; BP, Blood Pressure; APGAR, appearance pulse, grimace, activity, respiration; SRM, spontaneous rupture of membranes; LC-PUFA, long chain polyunsaturated fatty acids; AA, arachidonic acid; DA, docosahexaenoic aci

ASK FOR INFORMATION RETRIEVAL: PART I. BACKGROUND AND THEORY

We report the results of a British Library Research and Development Department funded design study for an interactive information retrieval system which will determine structural representations of the anomalous states of knowledge (ASKs) underlying information needs, and attempt to resolve the anomalies through a variety of retrieval strategies performed on a database of documents represented in compatible structural formats. Part I discusses the background to the project and the theory underlying it, Part II (next issue) presents our methods, results and conclusions. Basic premises of the project were: that information needs are not in principle precisely specifiable; that it is possible to elicit problem statements from information system users from which representations of the ASK underlying the need can be derived; that there are classes of ASKs; and, that all elements of information retrieval systems ought to be based on the user\u27s ASK. We have developed a relatively freeform interview technique for eliciting problem statements, and a statistical word co-occurrence analysis for deriving network representations of the problem statements and abstracts. Structural characteristics of the representations have been used to determine classes of ASKs, and both ASK and information structures have been evaluated by, respectively, users and authors. Some results are: that interviewing appears to be a satisfactory technique for eliciting problem statements from which ASKs can be determined; that the statistical analysis produces structures which are generally appropriate both for documents and problem statements; that ASKs thus represented can be usefully classified according to their structural characteristics; and, that of thirty-five subjects, only two had ASKs for which traditional \u27best match\u27 retrieval would be intuitively appropriate. The results of the design study indicate that at least some of our premises are reasonable, and that an ASK-based information retrieval system is at least feasible

Sclerostin does not play a major role in the pathogenesis of skeletal complications in type 2 diabetes mellitus

In contrast to previously reported elevations in serum sclerostin levels in diabetic patients, the present study shows that the impaired bone microarchitecture and cellular turnover associated with type 2 diabetes mellitus (T2DM)-like conditions in ZDF rats are not correlated with changes in serum and bone sclerostin expression. INTRODUCTION: T2DM is associated with impaired skeletal structure and a higher prevalence of bone fractures. Sclerostin, a negative regulator of bone formation, is elevated in serum of diabetic patients. We aimed to relate changes in bone architecture and cellular activities to sclerostin production in the Zucker diabetic fatty (ZDF) rat. METHODS: Bone density and architecture were measured by micro-CT and bone remodelling by histomorphometry in tibiae and femurs of 14-week-old male ZDF rats and lean Zucker controls (n = 6/group). RESULTS: ZDF rats showed lower trabecular bone mineral density and bone mass compared to controls, due to decreases in bone volume and thickness, along with impaired bone connectivity and cortical bone geometry. Bone remodelling was impaired in diabetic rats, demonstrated by decreased bone formation rate and increased percentage of tartrate-resistant acid phosphatase-positive osteoclastic surfaces. Serum sclerostin levels (ELISA) were higher in ZDF compared to lean rats at 9 weeks (+40 %, p < 0.01), but this difference disappeared as their glucose control deteriorated and by week 14, ZDF rats had lower sclerostin levels than control rats (-44 %, p < 0.0001). Bone sclerostin mRNA (qPCR) and protein (immunohistochemistry) were similar in ZDF, and lean rats at 14 weeks and genotype did not affect the number of empty osteocytic lacunae in cortical and trabecular bone. CONCLUSION: T2DM results in impaired skeletal architecture through altered remodelling pathways, but despite altered serum levels, it does not appear that sclerostin contributes to the deleterious effect of T2DM in rat bone

ASK FOR INFORMATION RETRIEVAL: PART II. RESULTS OF A DESIGN STUDY

In \u27ASK for Information Retrieval: Part P1, we discussed the theory and background to a design study for an information retrieval (IR) system based on the attempt to represent the anomalous states of knowledge (ASKs) underlying information needs. In Part 11, we report the methods and results of the design study, and our conclusions

Baseline and greenhouse-gas emissions in extensive livestock enterprises, with a case study of feeding lipid to beef cattle

For accurate calculation of reductions in greenhouse-gas (GHG) emissions, methodologies under the Australian Government's Carbon Farming Initiative (CFI) depend on a valid assessment of the baseline and project emissions. Life-cycle assessments (LCAs) clearly show that enteric methane emitted from the rumen of cattle and sheep is the major source of GHG emissions from livestock enterprises. Where a historic baseline for a CFI methodology for livestock is required, the use of simulated data for cow-calf enterprises at six sites in southern Australia demonstrated that a 5-year rolling emission average will provide an acceptable trade off in terms of accuracy and stability, but this is a much shorter time period than typically used for LCA. For many CFI livestock methodologies, comparative or pair-wise baselines are potentially more appropriate than historic baselines. A case study of lipid supplementation of beef cows over winter is presented. The case study of a control herd of 250 cows used a comparative baseline derived from simple data on livestock numbers and class of livestock to quantify the emission abatement. Compared with the control herd, lipid supplementation to cows over winter increased livestock productivity, total livestock production and enterprise GHG emissions from 990 t CO2-e to 1022 t CO2-e. Energy embodied in the supplement and extra diesel used in transporting the supplement diminished the enteric-methane abatement benefit of lipid supplementation. Reducing the cow herd to 238 cows maintained the level of livestock production of the control herd and reduced enterprise emissions to 938 t CO2-e, but was not cost effective under the assumptions of this case study

Habitat-specific breeder survival of Florida Scrub-Jays: inferences from multistate models

Quantifying habitat-specific survival and changes in habitat quality within disturbance-prone habitats is critical for understanding population dynamics and variation in fitness, and for managing degraded ecosystems. We used 18 years of color-banding data and multistate capture-recapture models to test whether habitat quality within territories influences survival and detection probability of breeding Florida Scrub-Jays (Aphelocoma coerulescens) and to estimate bird transition probabilities from one territory quality state to another. Our study sites were along central Florida\u27s Atlantic coast and included two of the four largest metapopulations within the species range. We developed Markov models for habitat transitions and compared these to bird transition probabilities. Florida Scrub-Jay detection probabilities ranged from 0.88 in the tall territory state to 0.99 in the optimal state; detection probabilities were intermediate in the short state. Transition probabilities were similar for birds and habitat in grid cells mapped independently of birds. Thus, bird transitions resulted primarily from habitat transitions between states over time and not from bird movement. Survival ranged from 0.71 in the short state to 0.82 in the optimal state, with tall states being intermediate. We conclude that average Florida Scrub-Jay survival will remain at levels that lead to continued population declines because most current habitat quality is only marginally suitable across most of the species range. Improvements in habitat are likely to be slow and difficult because tall states are resistant to change and the optimal state represents an intermediate transitional stage. The multistate modeling approach to quantifying survival and habitat transition probabilities is useful for quantifying habitat transition probabilities and comparing them to bird transition probabilities to test for habitat selection in dynamic environments

Struggling for food in a time of crisis: Responsibility and paradox

Responsibility is a useful lens through which to examine the current state of food poverty in the UK in the context of the Covid‐19 crisis, noting that this concept contains several paradoxes. Currently, responsibility involves the voluntary sector, the food industry and the state, a situation which the author has been exploring for the last five years in an ethnographic study of food poverty and food aid in the UK. Food aid organizations, especially food banks, have mushroomed during the period of austerity. This reveals the first paradox: namely, that the existence of food banks conveys the message that ‘something is being done’, but in actuality this is very far from being sufficient to meet the needs of either the ‘old’ or ‘new’ food insecure. The second paradox is that at the onset of the crisis, a government which had been responsible for inflicting austerity on the country for 10 years, dramatically reversed some of its policies. However, predictably, this did not change the situation vis‐à‐vis food insecurity. The third paradox is that the frequent rhetoric invoking the two world wars has not resulted in lessons being learned – notably, the creation of a ministry to deal with food and rationing, as in the Second World War. The final paradox relates to Brexit and its likely deleterious effects on food security, particularly if no ‘deal’ is achieved with the European Union, as seems likely. The voluntary food aid sector, try as it may, cannot possibly assume responsibility for the long‐standing and now hugely increased problems of food insecurity. That belongs to the state